Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF CANCER》 1999-06
Add to Favorite Get Latest Update

Oxaliplatin in the treatment of advanced colorectal cancer——a review of clinical studies

Armand J P 1 , SUN Yan 2,GUAN Zhong zhen 3, LiyaJu 4? ? WTBX 1 Institute Gustave Roussy, 94800, Villejuif ,France 2 Chinese Academy of Medical Science Cancer Hospital, Beijing 100021,P R China 3 Cancer Center, Sun Yet sen Univer  
An international multi center randomized phase Ⅲclinical study comparing LV 5FU 2 (De Gramont regime) vs LV 5FU 2+oxaliplatin confirmed the superiority of the oxaliplatin combination arm in the treatment of advanced colorectal cancer (CRC)(RR 50%vs 21 9%, and the PFS 8 7 m vs 6 1 m) Similar results were obtained in another multi center study in France (RR was 53%for FU/FA+oxaliplatin vs 16%for FU/FA, DFS was 8 9 m vs 5 2 m) Oxaliplatin has been recognized as one of the effective drugs for the first line therapy of advanced CRC Moderate granulocytopenia and neuro sensory symptoms were found to be the dose limiting toxicities, and renal toxicity was not encountered even if high dose was administered Further clinical studies are still on going in USA and Europe in order to define the best combination regime for advanced CRC
【Key Words】： Colorectal cancer Oxaliplatin Chemotherapy
【CateGory Index】： R735.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Department of Oncology, Hefei No.1 People's Hospital, Hefei 230011,Anhui WANG Fang-lin;Efficacy Observation on the Treatment of Advanced Large Intestine Cancer with Oxaliplatin(L-OHP) Combined with Cf and 5-FU[J];Journal of Anhui Health Vocational & Technical College;2009-02
2 QIAN Hong1,2,JIN Yong1(1.Anhui Medical University,Hefei 230032;2.Anqing Naval Hospital,Anqing 246003);Clinical results of oxaliplatin-containing regimen for the patients with advanced hepatocellular carcinoma[J];Anhui Medical and Pharmaceutical Journal;2007-07
3 YANG Chun-xu ,HUANG Hai-xing,LI Gui-sheng Department of Oncology,The Fourth Affiliated Hospital,Guangxi Medica l University,Liuzhou 545005,P.R.China;Clinical Study on Patients with Adva nced Gastric Cancer Treated with Oxaliplatin Combining with Hyd roxycamptothecine[J];Chinese Journal of Cancer;2002-08
4 DIAO Yong-shu,LI Hong,YI Qiong;Nursing of Oxaliplatin Combined Chemotherapy in Patients with Advanced Colorectal Cancer[J];West China Medical Journal;2005-03
5 HUANG Zong-qiong,HE Min*,XU Hui-qiong,et al.(Ward 2 of Oncology Department,West China Hospital,Sichuan University,Chengdu 610041,China);Observation and Nursing of Advanced Gastrointestinal Cancer Treated by Oxaliplatin Combined with 5-Fluracil in Different Intravenous Infusion Ways[J];West China Medical Journal;2008-02
6 ;CPT-11联合化疗方案治疗晚期胃肠道癌的护理[J];Journal of Clinical Nursing;2007-02
7 YANG Lan-ping, HUANG Han-sheng, CHEN Hong, et al. Department of Chemotherapy, Liuzhou Tumor Hospital, Liuzhou 545005;Time-chemotherapy with Navelbine plus Oxaliplatin regimen in advanced lung cancer[J];Chinese Clinical Oncology;2004-01
8 FU Wei,WU Jian-ping,LU Hong.The First People’s Hospital of Changshu,Changshu 215500;Clinical study of the treatment of advanced Gastric cancer mainly by oxaliplation combined with chemotherapy[J];Chinese Clinical Oncology;2004-06
9 MA Ai-ying,CHEN Qing-feng. The Department of Oncology,The 455 Hospital of PLA,Shanghai 200052,China;Clinical observation of interventional chemotherapy with oxaliplatin combinated with chemotherapy treating hepatic carcinoma[J];Chinese Clinical Oncology;2005-04
10 Wang Cai-lian, Li Su-yi, Zhang Lin (Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009,China);Evaluation on the treatment of metastatic gastric carcinoma chiefly using Oxaliplatin[J];Journal of Southeast University;2003-06
China Proceedings of conference Full-text Database 1 Hits
1 Department of Onclogy, China-Japan friendship hospital LI Yuan,CUI Hui-juan, HUANG Jin-chang, WU Xiao-qin.;Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction on prevention of peripheral neuro-sensory toxicity caused by oxaliplatin[A];[C];2006
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 GUAN Zhong-zhen HE You-jian et al(Medical Oncology Department of Tumor Hospital, Sun Yat-sen Univ. of Med Sci-, Guangzhou 510060);THE TREATMENT OF ADVANCED GI CANCER WITH HIGH DOSE CF AND 5-FU (HDCF/5-FU)——A PILOT STUDY IN CHINA[J];Chinese Journal of Cancer;1989-06
2 GUAN Zhong zhen 1,SUN Xiao fei 1,FENG Feng yi 2,et al. 1. Department of Medical Oncology,Cancer Center,Sun Yat sen University of Medical Sciences,Guangzhou 510060,P.R. China 2. Department of Medical Oncology,Cancer Center,CAMS Beijing 100021,P;Clinical study of irinotecan in Chinese patients with metastatic colorectal cancer[J];CHINESE JOURNAL OF CANCER;1999-06
3 ZHANG Li 1? 琇IN Zhong 2,XIA Zhong jun 1,et al 1 Cancer Center,Tumor Hospital,Sun Yat Sen University of Medical Science, Guangzhou 510060, P R China 2 Department of Oncology, Guangzhou Railway Central Hospital, Guangzhou 510080, P R;Clinical study on the treatment of advanced colorectal carcinoma with high dose leucovorin plus 5-Flouruorail continuous infusion(biweek schedule)[J];CHINESE JOURNAL OF CANCER;2000-04
4 ZHANG Li*, LI Su, LIAO Hai, JIANG Wen qi, GUAN Zhong zhen Department of Medical Oncology, Cancer Center,Sun Yat sen University of Medical Sciences, Guangzhou 510060, P.R.China;Phase Ⅰ Trial of Pharmacokinetics and Human Tolerability to 10-Hydroxycamptothecin in Patients with Advanced Malignancy[J];Chinese Journal of Cancer;2001-12
5 YANG Chun-xu ,HUANG Hai-xing,LI Gui-sheng Department of Oncology,The Fourth Affiliated Hospital,Guangxi Medica l University,Liuzhou 545005,P.R.China;Clinical Study on Patients with Adva nced Gastric Cancer Treated with Oxaliplatin Combining with Hyd roxycamptothecine[J];Chinese Journal of Cancer;2002-08
6 SHI Yan-Xia1,2, XU Rui-Hua1,2, JIANG Wen-Qi1,2, ZHANG Li1,2, LIN Tong-Yu1,2, LI Yu-Hong1,2, XIA Zhong-Jun1,2, LUO Hui-Yan1,2, HAN Bing1,2, WANG Feng1,2, HE You-Jian1,2, GUAN Zhong-Zhen1,2 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Medical Oncology, Cancer Center, Sun Yat-sen Universisty, Guangzhou, Guangdong, 510060, P. R. China;Efficacy of Gemcitabine Combined Oxaliplatin on Advanced Pancreatic Cancer[J];Chinese Journal of Cancer;2007-12
7 Ma Jun　 Hong Minghuang 　Min Huaquing, et alCancer Center, Sun Yatsen University of Medical Sciences ,GuangZhou 510060　　;A randomized clinical trial of neoadjuvant chemotherapy combined with radiotherapy for advanced nasopharyngeal carcinoma[J];CHINESE JOURNAL OF CANCER;1998-04
8 SUN Yan1, GUAN Zhongzhen2, JIN Maolin3, et al. 1Chinese Academy of Medical Sciences Cancer Hospital, Beijing 100021, China2Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhou 510060, China3Beijing Tumor Hospital, Beijing 100036, Chi;A multicenter randomized phase II trial of oxaliplatin in patients with advanced colorectal cancer[J];CHINESE JOURNAL OF CANCER;1999-03
9 HE Xia1, HONG Minghuang1,HE Youjian2,et al Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yatsen University of Medical Scieces, Guangzhou 510060,China;Preliminary study of new chemotherapy regimen and therapeutic strategy on distant metastatic nasopharyngeal carcinoma[J];CHINESE JOURNAL OF CANCER;1999-03
10 Wang Tao Jiang Zefei # Song Santai Shen Ge et al Department of Breast Cancer,No 307 Hospital,Academy of Military Medical Science,Beijing 100039,China;Study on regularity and treatment of hand-foot syndrome induced by xeloda as a therapy to breast cancer[J];Oncology Progress;2004-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 MA Hua-zhi , LIU Zheng-xing , WANG Quan-jun , et al(Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850 , China);THE BREAKING EFFECTS OF CISPLATIN, CARBOPLATIN AND DICYCLOPLATIN ON pBR322 PLASMID DNA[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
2 WANG An-Xun1, LI Su2, DING Xue-Qiang1, CHEN Yu1, CHEN Dan1 1. Department of Stomatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China 2. Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Antitumor Effects of Ring-closed and Ring-opened Hydroxycamptothecin on Oral Squamous Carcinoma Cell Line Tca8113[J];Chinese Journal of Cancer;2005-08
3 YAO Yang, SUN Yuan-Jue, ZHAO Hui, GUO Yue-Wu, LIN Feng, CAI Xun, TANG Xiao-Chun Department of Medical Oncology, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P. R. China;Short-Term Effects of Chemotherapy Combined with Hydroxycamptothecine and Oxaliplatin in Treatment of Recurrent and Metastatic Colorectal Cancer[J];Chinese Journal of Cancer;2006-08
4 YIN Hong-xing1, ZHANG Shu-jia1,2, ZHENG Xue-fang2, YANG Lan-yi1(1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China;2. Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622, China);Review in the Antitumor Research of Selenium[J];Journal of Dalian University;2008-06
5 TUO Ya 1, SU Xiu Lan 1, LU Gui Rong 1, XIN Xue Dong 1, WANG Wen Li 1, KE Yang 1, BAO Wen Yu 2 (1. Laboratory of Cytogenetics, Beijing Institute for Cancer Research, Medical College, Beijing University, Beijing 100034, China; 2. Shanghai United;Analysis of gene expression patterns in antiangiogenesis Traditional Chinese Medicine by cDNA microarray[J];Academic Journal of Second Military Medical University;2002-03
6 REN Li, ZHU Jiang, GOU Hongfeng, YAN Xi, HE Jianping. Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;A randomized clinical trial of chemotherapy combined with oxaliplatin and cisplatin plus navelbine in the treatment of advanced non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2005-06
7 WANG Xiaohua, HOU Mei, CAO Dan, GOU Hongfeng, YANG Yu. Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Randomly clinical study of vinorelbine/cisplatin and vinorelbine/oxaliplatin regimens in the treatment of advanced non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2006-01
8 LIU Weiping,ZHANG Yongli,SUN Jialin ( Metal-based Drug Lab., Kunming Institute of Precious Metals, Kunming, Yunnan 650221, China );Future Development of Platinum Anticancer Drugs[J];Precious Metals;2005-01
9 YANG Chuanbiao XU KechengGuangzhou Fuda cancer hospital;Function of Anti-tumor of Chinese Medication[J];International Medicine & Health Guidance News;2004-18
10 DING Zuo-peng,DENG Ke-xue(Dept of Medical Imaging,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001);Diagnostic value of liver carcinoma with portal vein cancer thrombosis by multi-slice spiral CT of image post-processing technique[J];Anhui Medical and Pharmaceutical Journal;2010-01
China Proceedings of conference Full-text Database 4 Hits
1 YANG Mei,TANG Zhi-qiang(Dept. of Pharmacy,Cancer Hospital of China Academy of Medical Science, Beijing 100021,China);Research and exploration in tumor circadian therapy[A];[C];2006
2 Department of Onclogy, China-Japan friendship hospital LI Yuan,CUI Hui-juan, HUANG Jin-chang, WU Xiao-qin.;Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction on prevention of peripheral neuro-sensory toxicity caused by oxaliplatin[A];[C];2006
3 Li-qun JIA,Yan-ni LOU (Department of TCM Oncology,China-Japan Friendship Hospital,Beijing,100029,China);The external use of Chinese herbs in chemotherapy-induced peripheral neuropathy:A Clinical Study[A];[C];2009
4 JIA Liqun,LOU Yanni (Department of TCM Oncology,China-Japan Friendship Hospital,Beijing 100029,China);The External Use of Chinese Herbs in Chemotherapy-induced Peripheral Neuropathy:A Clinical Study[A];[C];2009
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved