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Induction of apoptosis in human colorectal carcinoma cell line SW 260 by THP

PENG Xu yang, HE Zhi ding, WU Yang Hunan Province Tumor Hospital, Changsha 410006,P.R.China  
Objective:To investigate whether pirarubicin (THP) induce apoptosis in SW 260, a colorectal carcinoma cell line. Methods:The effect of THP on apoptosis induction of SW 260 cells line was confirmed on the basis of morphology, ultrastructure and agarose gel electrophoresis of DNA, and percentage of DNA fragmentation. Results:THP induced SW 260 cell apoptosis. When treated with different concentrations of THP (5~15 mol/L) for different time (24~48 h), SW 260 cells showed typical apoptosis features. The increase of the concentration of THP to 15 μm/L resulted in necrosis of SW 260 cells. Conclusion:THP could inhibit SW 260 development and induce apoptosis in a concentration and time dependent manner.
【Fund】: 湖南省卫生厅重点课题资助!(编号 95 -6 8)
【CateGory Index】: R735.35
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