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《CHINESE JOURNAL OF CANCER》 2000-04
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Boanmycin induces apoptosis in human nasopharyngeal cancer cells

GUAN Zhong 1, YE Hui 1, YANG Xiao ping 2,et al.1.Sun Yat sen Memorial Hospital, Sun Yat sen University of Medical Sciences, Guangzhou 510120,P.R.China. 2.Cancer Institute, Sun Yat sen University of Medical Sciences,Guangzhou 510080,P.R.China.  
Objective: To investigate the antitumor mechanisms of boanmycin (bleomycin A6) on human nasopharyngeal cancer. Method: Apoptosis induced by boanmycin in human nasopharyngeal cancer SUNE 1 cells was tested by fluorescent microscope, flowcytometry and DNA gel electro phoresis. Result: When incubated with boanmycin (50 μg/ml) for 10 hours, SUNE 1 cells showed morphological changes associated with the characters of apoptosis under fluorescent microscope. In flowcytometry analysis sub G1 peak appeared in DNA frequency distribution histograms. Typical DNA ladder was found during gel electrophoresis. Conclusion: Boanmycin induces apoptosis in SUNE 1 cells in vitro, which may be one of its antitumor mechanisms of action against nasopharyngeal cancer.
【CateGory Index】: R739.63
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