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《CHINESE JOURNAL OF CANCER》 2000-04
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Study on reversal of multidrug resistance in leukemia by tetramethylphylpyrazine combining with cyclosporin A

YANG Lan 1,YANG Ping di 2,LIANG Rong 1,et al 1 Department of Hematology,Xijin Hospital,The Fourth Military Medical University, Xian 710032, P R China 2 Department of Hematology and Oncology, Naval General Hospital, Beijing 100037, P R  
Objective: To search effective combination of multidrug resistance(MDR) modulators Methods:The reversal effects of tetramethylphylpyrazine(TMPZ)on the drug resistance of HL-60/VCR was evaluated by utilizing RT-PCR,Western blot and MTT Twenty one refractory and relapsed leukemia patients were received chemotherapy,combined with TMPZ and cyclosporin A(CsA) Results: Sensitivity of HL-60/VCR to multidrug chemotherapy was enhanced and p170 expression was decreased by the single application of TMPZ The reversal effectiveness of the TMPZ in combination with CsA to multidrug resistance of refractory and relapsed leukemia was favorable The complete remission(CR) rate was 44 4%and partial remission(PR) rate was 33 3%in the treatment group Conclusion: TMPZ in combination with CsA might be a safe and effective MDR reversing manipulation,and can be applied in the chemotherapy of refractory and relapsed acute leukemia
【Key Words】: Leukemia Tetramethylphylpyrazine Multidrug resistance
【Fund】: 陕西省自然科学基金!项目 (编号97SM5 3)资助
【CateGory Index】: R733.71
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