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An in vitro study of effect of Kushen compound preparation on human colon cancer cell line SW480

ZHOU Lin, AI Zhong li, LIU Zhi su,et al Department of General Surgery of the Second Affiliated Hospital of Hubei Medical University, Wuhan 430071, P R China  
Objective: To explore the effect of Kushen compound preparation on human cancer cell line SW480 in vitro Methods: Inhibition of SW480 cell growth by Kushen compound preparation was determined by MTT assay and growth curve, and apoptosis was detected by morphological assay and flow cytometry (FCM) Results: The solution of Kushen compound preparation showed dose dependent and time dependent inhibitory effects on the proliferation in SW480 cell line The cells treated with 30 mg/ml compoumd for 48 hours showed characters of apoptosis under light and electronic microscopy Sub G 1 peak was detected by FCM, the ratio of apoptosis was 11 13% The cell percent of S phrase increased from 25 41%to 41 27%(P 0 01), and that of G 2/M phrase decreased from 6 74%to 1 35%(P 0 01) after treatment Conclusion: In vitro, Kushen compound preparation has growth inhibiting effect and may induce apoptosis in SW480 in a certain dose range, which may be one of the antineoplastic effects of Kushen compound preparation
【CateGory Index】: R735.35
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Chinese Journal Full-text Database 10 Hits
1 ZHANG Li GU Nailong;Effect of Yanshu Injection Combined with Microwave Hyperthermia for Late Cancer:An Observation of 45 Cases[J];Journal of New Chinese Medicine;2008-11
2 GE Cheng hua, WANG Shi wei, CHEN Ye, GU Wen jun, GAO Feng, LU Feng (Central Hospital of Yangpu District, Shanghai 200090, China);Study of composite Kushen injection in postoperative chemotherapy of gastric cancer[J];Modern Jorunal of Integrated Traditional Chinese and Western Medicine;2004-05
3 XU Wei-dan,GAO Yun,SHAO Xi-ying,et al.;Inhibiting Effect of Combination Matrine and Cisplatin on Cells Proliferation in Human Osteosarcoma MG-63 Cell Line[J];Journal of Oncology;2009-05
4 Liu Yaxian, Li Jijun, Fu Xiaomei, et al (The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011);Experimental Study on Induction of Apoptosis by Qige Fang in Leucocythemia Cell Line K562[J];Chinese Journal of Information on TCM;2003-10
5 LIU Bao-Rui, XU Xiu-Li, LIU Wen-Chao,MENG Xian-Zhi (Dept of Oncology ,Drum Tower Hospital, Faculty of Medicine, Nanjing University, Nanjing 210008);Effects of four extracts of traditional Chinese medicinal materials on the proliferation of human lung cancer A549 cell line[J];Chinese Pharmacological Bulletin;2002-01
6 MAO Hai-bo,LIU Guo-long,ZHU Guo-dong(Dept.of Oncology,Guangzhou Municipal First People's Hospital,Guangzhou 510180,China);Preventive Effect of Complex Sophora Flavescens Injection on Hepatic Lesion Caused by Chemotherapy:Clinical Observation[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2008-03
7 LIN Lian-xing,XU Zhi-yuan,CAI Shun-hou,YAN Ming-ming (Dept. of Radiotherapy,Sun Yat-sen Medical University Affiliated Shantou Hospital,Shantou 515031,China);Efficacy of Compound Matrine Injection in Combination with Hyperfractionated Radiotherapy for Early Nasopharyngeal Carcinoma[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2009-03
8 HUO Dan1,ZHANG Xiao-li1,MA Yu-fang2,WANG Ji-hong2(1.Medical College of Wuhan University,Wuhan 430071,China;2.Dept. of Hematology and Oncology,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,China);Postoperative Use of Compound Radix Sophorae Flavescentis Injection in Combination with Concurrent Radiochemotherapy for Patients with Phase Ⅲ Gastric Cancer:A Clinical Study[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2011-08
9 Zhou Lin,Han Shiping,Yang Cong, et al. Hangzhou Red Cross Hospital,Hangzhou(310003),China;Apoptosis of Human Colon Cell Line SW480 Induced by Radix Sophorae Elavescentis Compouds Preparation Contained Serum in Vitro[J];Chinese Journal of Surgery of Integrated Traditional and Western Medicine;2006-01
10 CAI Yuecheng,YE Jinhui,HE Baozhen,et al.The First People's Hospital of Zhaoqing,Guangdong,526021,China;Clinical study of treating metastatic bone cancer with radiotherapy and composite kushen injection[J];Chinese Journal of Primary Medicine Pharmacy;2004-07
Chinese Journal Full-text Database 2 Hits
1 YANG Hui-Ling, WANG Xue-Lan, WU Yi-Fang, ZHENG Qin, MA Zhi-Kai, WU Jin-Lin [WT5”BX〗Department of Pathophysiology, Sun Yat-sen University of Medical Sciences, Guangzhou (510089);Study of the effects of Xiao Chai Hu Tang on the growth and structure of S 180 bearing tumor mice[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1998-03
2 Chen Hong,Zhang Zhenshu,Zhang Yali,Jiang Bo,Zhou Dianyuan (Department of Gastroenterology,Nanfang Hospital,The First Military Medical University,Guangzhou 510515);Curcumin Induces Lovo Cell Apoptosis[J];CHINA JOURNAL OF BASIC MEDICINE IN TRADITIONAL CHINESE MEDICINE;1999-03
Chinese Journal Full-text Database 10 Hits
1 LIU Shun-zhen et al (College of Chemistry and Life Sciences,Guangxi Teachers Education University,Nanning,Guangxi 530001);Comparative Analysis of the Volatile Components in the Leaves and Fruit Peel of Fortunella margarita[J];Journal of Anhui Agricultural Sciences;2011-26
2 LIANG Guang,LI Xiao-kun,LIU Min,HUANG Zhi-feng (School of Pharmacy,Wenzhou Medical College,Wenzhou Zhejiang 325035);Progress on pharmacological properties of zedoary turmeric oil[J];Anhui Medical and Pharmaceutical Journal;2006-12
3 ZHAN Yan-Yan, WU Qiao Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen,Fujian,361005, P.R.China;Translocation of Orphan Receptor TR3 from Nuclei to Mitochondria Induced by Staurosporine[J];Chinese Journal of Cancer;2004-12
4 Wan Xuying,Chen Zhe TCM Section,Changhai Hospital of Second Military Medical University,Shanghai (200433);Primary Liver Cancer Treated by Matrine Injection with TACE Operation[J];Journal of Zhejiang College of Tcm;2002-02
5 ZHANG Yuhong1) CHAI Weizhong2) ZHAO Jianxiong3)(1)The Hospital of Beijing Normal University,100875,Beijing,China;2)Public Health School of Peking University,100083,Beijing,China;3)Institute of Traditional Chinese and Western Integrated Medicine,Lanzhou University Medical College,730000,Lanzhou,China);FUZHENG-YILIU DECOCTION ON TUMOR CELL TELOMEREASE AND BLOOD VISCOSITY IN TUMOR-BEARING MICE[J];Journal of Beijing Normal University(Natural Science);2008-03
6 Luo Wenji(The First Hospital of People of Xiaoshan County; Zhejiang; The Hospital of TCM of Zhejiang Province, Hang Zhou);Experimental Research of Sophocarpidine Inducing Leukemia Cell HL-60 into Differentiation[J];China Journal of Traditional Chinese Medicine and Pharmacy;2001-05
7 ZHAO Lian-hua, JING Li-xin, CHEN Yong-mei, CAO Li-li, LUO Xue-ya, YUE Ming, MA Yan-jie, GAO Le (The Medical College of Dalian University, Dalian 116622, China);Study on inhibitory effect of F3 new preparation from Astragalus membramaceus on the cell of human stomach cancer[J];Journal of Dalian University;2003-02
8 Zuo Yunfei,Zhang Yaozheng,Zheng Yun [WT5BX]Department of Laboratory,Dalian Medical University,Dalian,China;The study of the antitumor activity of elemene by flow cytometry(FCM)[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;2000-01
9 SI Wei ke, CHENG An, LI Peng, LIU Bing, GAO Li hong, YAO Jie (Department of Clinical Biochemistry, Third Military Medical University, Chongqing 400038,China);Study on apoptosis of human hepatoma cell line HepG_2 induced by matrine[J];Acta Academiae Medicine Militaris Tertiae;2001-07
10 SI Wei ke, LI Peng, YAO Jie (Department of Clinical Biochemistry, Third Military Medical University, Chongqing 400038, China);Effects of matrine on HepG_2 cells at metabolism level and gene level[J];Acta Academiae Medicine Militaris Tertiae;2002-11
China Proceedings of conference Full-text Database 1 Hits
1 Yuzhu Chen;Gaimei She;Department of Chinese Pharmacy,Beijing University of Chinese Medicine;;Research Progress of Curcumae Rhizoma[A];[C];2014
Chinese Journal Full-text Database 10 Hits
1 GUO Wei, ZHAO Ze-zhen, SHAN Bao-en, WEI Li-zhen, WEN Deng-gui(Hebei Cancer Institute, The 4+{th} Hospital of Hebei Medical University, Shijiazhuang 050011, China);REPORT ON THE ANTIMUTAGENICITY AND ANTI-TUMOR ACTIVITY OF SIX KINDS OF CHINESE MEDICINAL HERBS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
2 CHEN Jun-xia 1 ,XIA Jun 2 ,LIU Ji-wei 3 ,CUI Xiu-yun 1,ˇ (1.Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian116027,Liaoning,China;2.Department of Biochemistry and Molecular Biology,Bengbu Medical College,Bengbu233003,Anhui,China;3.Department of Oncology,First Affiliated Hospital,Dalian Medical University,Dalian116011,Liaoning,China);Experimental Study on Apoptosis Induced by Ginsenoside Rg3 in Human MCF-7 Breast Cancer Cell Line[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-04
3 YE Min(Dept.of Pharmacy,The Central Hospital of Ma'anshan,Ma'anshan,Anhui Province,243000);Effects of water extracts from coix lachryma-jobi on immune function in immune suppressive mice[J];Anhui Medical and Pharmaceutical Journal;2006-10
5 LUO Si HUANG Wen-jin MO Chi-chunSU Chao-kan ZHANG Zhen-qain (Department of Epidemiology, Gvangxi Medical College Nanning 530000);A STUDY ON THE CELL CYCLE KINETICS OF PERIPHERAL BLOOD LYMPHOCYTES OF THE MEMBERS WITH LIVER CANCER FAMILIES[J];Chinese Journal of Cancer;1990-04
6 LI Feng-qin ZHANG Da-chui QU Xian-jun WANG Hui ZHOU Ling ZUO Chun-xu(Institute of Materia Medica, Shandong Aademy of Medical Sciences. Jinan, 250001);STUDIES ON THE ANTITUMOUR ACTIVITIES OF LUSUN EXTRACTS[J];Chinese Journal of Cancer;1993-03
7 JIANG Chao, QING Chen, MENG Ling hua, et al. Shanghai Institute of Material Medical,Chinese Academy of Sciences,Shanghai 200031,P.R.China;Inhibitory effects of China ganoderma lucid essence (CGLE) on DNA topoisomerases and its ability to induce apoptosis of K562 cells[J];CHINESE JOURNAL OF CANCER;1999-06
8 CHEN Rui chuan, SU Jin hua, MA Sheng ping, et al Cancer Research Center of Xiamen University, Xiamen 361005, P R China;Induction of human gastric cancer MGC 80-3 cell apoptosis by photoactivated curcumin[J];CHINESE JOURNAL OF CANCER;2000-04
9 ZHOU Jun min, CAO Jian guo, LIAO Duan fang Department of Pharmacology, Hengyang Medical College, Hengyang 421001, P R China;Effects of etoposide on growth proliferation and apoptosis in human HIC/S cells[J];CHINESE JOURNAL OF CANCER;2000-04
10 ZHANG Yan, JIANG Ji kai*, LIU Xiao shan, et al Department of Clinical Biochemistry, Chongqing University of Medical Sciences, Chongqing 400016, P R China;Differentiation and apoptosis in K562 erythroleukemia cells induced by matrine[J];CHINESE JOURNAL OF CANCER;2000-08
China Proceedings of conference Full-text Database 1 Hits
1 Huang Hong-si, Wei Peng-ya, Huang yan-jiang (Department of microbiology and immunology , Youjiang medical college for nationalities , Bose 533000,Guangxi ,China);Cytotoxicity of Astragalus Polysaccharides Combined With 5-Fluororuacil on Tumor Cells[A];[C];2006
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Shun-guan1 LI Lin21Department of Oncology, Second People's Hospital of Guangdong Province, Guangzhou 510317, China; 2Department of Pharmacology, First Military Medical University, Guangzhou 510515, China;Inhibition of river clam extract LX01 on human lung epithelial carcinoma cell line A549[J];Journal of First Military Medical University;2004-08
2 CHEN Da-li, HUANG Tao School of Traditional Chinese Medicine, Southern Medical University, Guangzhou510515, China;In vivo and in vitro anti-tumor effect of Sanjie Kangliu Decoction[J];Journal of Southern Medical University;2006-04
3 HUANG Qing-jie1,2,LI Mao-xing1,3,LIU Xiong1 1 Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China; 2 Gansu Province Hospital of Traditional Chinese Medcine;3 Lanzhou General Hospital of Lanzhou Military;Progress of Study on Treatment of Drug-induced Liver Injury with TCM[J];Western Journal of Traditional Chinese Medicine;2012-07
4 Ning Si-qing;Xu Hai-sheng;YANG Chao;Xiangyang Central Hospital;;Clinical study of Compound Kushen Injection combined with FOLFOX4 chemotherapy in treatment of advanced gastric cancer[J];Drugs & Clinic;2015-03
5 DING Mingming;WU Mianhua;Nanjing University of Chinese Medicine;Jiangsu Provincial Coordination and Innovation Center of TCM Preventing and Treating Tumor;;Impact of Materia Medica on the Expressions of Apoptosis Induced Gene of Lung Cancer Cells[J];Western Journal of Traditional Chinese Medicine;2015-05
6 HU Jiacai1,LI Qingquan21Dept.of Integrated Traditional and Western Medicine,2Dept.of Respiratory,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effect of Tetramethypyrazine on the Proliferation and Apoptosis of Lung Cancer Cell Line of A549 and Its Mechanism[J];Medical Journal of Wuhan University;2010-01
7 LI Tie-min,WANG Run-tian,HAN Zhi-peng,YANG Zhi-qiang,CUI Cheng,DING Jun-ying(Department of Immunology,Institute of Basic Medical Science,Hebei Medical University,Shijiazhuang 050017,China);DYNAMIC STUDY ON EFFECT OF YILIUYIN ON THE EXPRESSION OF Bcl-2 AND Bax IN MOUSE TRANSPLANTED S180 TUMOR TISSUE[J];Journal of Hebei Medical University;2008-03
8 TIAN Yanling~* , LIU Jingsheng. * Department of Obstetrics and Gynecology, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China;Experimental study of the effect of Niuhuangtianlong prescription on the immunological function in mice with tumor and its anti-tumor effect[J];Hebei Medical Journal;2009-23
9 Fu Jun,Yu Jie,Xu Hongbin,Li Ling(Tenth People's Hospital Affiliated to Tongji University,ShangHai,200072,China);Systematic evaluation about efficiency detoxification of Chinese traditional medicine adjuvant chemotherapy for solid tumors[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2010-10
10 XU Tao,XU Rui-an(Institute of Molecular Medicine,Huaqiao University,Quanzhou 362021,China);Progress on Ati-Tumor Mechanism of Chinese Medicine and Its Active Ingredients[J];Journal of Huaqiao University(Natural Science);2009-04
China Proceedings of conference Full-text Database 1 Hits
1 Zhang Luo 2009 Grade Postgraduate,Nanjing University of Chinese Medicine,Nanjing, Jiangsu,China 210000;Progress on the research of traditional medicine injection against Lung Cancer[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 LIANG Yong-ju PAN Qi-chao(Cancer Institute , Sun Yat-Sen University of Medical Sciences Guangzhou·510060);EFFECTS OF MA-TE-LING INJECTION ON CYTOLINETIC[J];CHINESE JOURNAL OF CANCER;1995-06
2 Jiang Xurong, First Affiliated Hospital, Dalian Medical College;INDUCTION OF DIFFERENTIATION IN THE HUMAN ERYTHROLEUKEMIA CELL LINE K562 BY GINSENOSIDES[J];;1991-04
3 Wang Xiukun;Li Jiashi;Wei Luxue;et al.(Beijing University of TCM. Beijing 100029);The Effects of inhibiting Tumor in vitro of Alkaloids from the Seed of Sophora viciifolia[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1996-02
4 Zhu Yuanxiao Lai Cbunni Wang jianan Ji Yanshan Wang Huaichun Bai Yan (Institute of Basic Medical Sciences, Beijing 100850);Human Myeloperoxidase Gene cDNA Cloning and Expression in Acute leukemia[J];Chinese Journal of Biotechnology;1993-01
5 YUAN Cai, LU Shi-Qi and YAO Xian (Department of Pharmacology, Capital Institute of Medicine, Beijing);EFFECTS OF OXYMATRINE ON THE ANTITUMOR ACTIVITY AND TOXICITY OF CYCLOPHOSPHAMIDE IN MICE[J];Acta Pharmaceutica Sinica;1987-04
6 Xu Jianguo, Ma Junying, Yang Guisheng, Ren Liansheng, Guo Yadong Zhang Hongxiang(Shanxi Institute of Cancer Research, Taiyuan 030013);Differentiation of Human Leukemia Cell (HL-60) Induced by Sophora flavescens Ait. Decoction[J];China Journal of Chinese Materia Medica;1990-10
7 Guo Yong Pang Dexiang. Affiliated Hospital,Zhejiang College of TCM,Hangzhou,Zhejiang 310006;Experimental and Clinical Studies on Carcinomia of Colon Treated by Changliuping.[J];Journal of Traditional Chinese Medicine;1993-08
8 Dai Weizheng,Dai Haoliang,Zhang Jianwei, Department of TCM,Zhongshan Hospital,Shanghai.200032;Diagnostic Significance of TCM Tongue Diagnosis in Contrast with Enteroskopic Exam in Lower GI Tract Diseases[J];Journal of Traditional Chinese Medicine;1994-01
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