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Experimental study of suppress effect of microwave tissue coagulation on the reinoculated H_(22) cell

ZHENG Yun; LU Ming-de; CHENG Jun-wei, et al.( Department of Hapatobiliary Cancer Center, Sun Yat-Sen University of Medical Sciences, Cuangzhou 510060, P R. China)(Department of Hepatobiliary Surgery ,the First Affiliated Hospital of Sun Yat-sen Univers  
Objective: To determine the suppress effect of microwave coagulation therapy on the reinoculated H22 liver cancer. Methods: The tumor model was established by hypodermic inoculation of H22 hepatic carcinoma cells and treated with microwave coagulation (A group), surgical resection(B group ) or non-treatment (C group). The three groups were reinoculated subcutaneously with different amount of H22 carcinoma cells respectively. The cancer incidence of the reinoculated tumors was observed. Results: The cancer incidence was diminished with the decrease number of reinoculated cancer cells. When the number of the reinoculated cells was 107, the 2-month cancer incidences of the reinoculated tumor in group A, B and C were 25.0%,26. 3% and 77. 8%, which were almost equal in group A and B but significanly higher in group C(P 0. 01). When the number of the reinoculated cells was 106, the tumor incidences of the three groups were 6. 3%, 20. 0%, 55. 0% respectively. The incidence in C group was significantly higher in group C than that in A and B (P 0. 01 and P 0. 05). The difference between A and B was more remarkable. When the number of the reinoculated cells was 105 , the incidences of the three groups were 0. 0%, 18. 7%, 50. 0% respectively . There was no significant difference in cancer incidence between B and C but the incidence in A was significantly lower than that in C (P 0. 01).The difference between A and B was more remarkable in 105 than in 106. Conclusion: Both microwave tissue coagulation (MTC) and surgical resection exhibit the ability of resisting repeated challenge with viable tumor cells but in varying degrees. The ability of MTC was stronger than that of surgical resection.
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