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《CHINESE JOURNAL OF CANCER》 2000-08
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Differentiation and apoptosis in K562 erythroleukemia cells induced by matrine

ZHANG Yan, JIANG Ji kai*, LIU Xiao shan, et al Department of Clinical Biochemistry, Chongqing University of Medical Sciences, Chongqing 400016, P R China  
Objective: To investigate the anti tumor effect of matrine, a main composition of Sophora flavescens Ait Methods:Differentiation ofhuman erythroleukemia K562 cells was assessed by morphological changes and cytochemical stain, while the apoptosis was demonstrated by programmed cell death (PCD) assay Results: K562 cells treated with 0 1 g/L matrine were found differentiated and morphologically changed to polychromatic normoblasts and orthrochromatic normoblasts Treatment of the cells with matrine increased the percentage of benizidine positive cells from 1%～2%to 7% Cytochemical stain demonstrated that the periodict acid schiff (PAS) changed from negative to strong positive to give the positive rate of 100% Treatment of the cells with 1 0 g/L matrine for 24 hours induced distinct vacuoles and some apoptotic bodies in 30%of the cells, and apoptosis were also demonstrated by PCD Conclusion: Matrine in concentration of 0 1g/L can induce K562 cells differentiation while in concentration of 1 0g/L will induce apoptosis
【Key Words】： Matrine Differentiation Apoptosis Leukemia
【CateGory Index】： R733.7
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