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《Chinese Journal of Cancer》 2001-02
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Apoptosis Induction by Sijunzi Deco ction in Human Gastric Cancer Xenografts in Nude Mice

ZHAO Ai-guang 1* ,YANG Jin-kun 1 ,ZHAO Hai-lei 1 ,LIU Li-kun 2 1.Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,P.R.China2.Shangxi Chinese Medicine Institu te,Taiyuan 030  
Objective:The current study was designed to examine whether Sijunzi decoction coul d induce apoptosis in human gastric cancer xenografts in n ude mice.Methods:A human gastric adenocarcinoma cell line SGC-7901was grafted into 30nude mice.The animals in two e xperimental groups received either Sijunzi decoction for 40days or 5-fl uorouracil(5-FU)for 6days beginning 2days after grafting.The control animals received s aline according to an identical schedule.The animals were sacrified 41days after grafting.The therapeutic effect was determined by measuring of tumo r size and tumor weight.Apoptotic indices were examined with terminal deoxynucle otidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling(TUNEL)method and flow cytometry analysis.Morphological changes were observed by electron microscopy.Results:Comparing with controls,tumor grow th was significantly inhibited by Si junzi decoction(34.33%,P0.05)or 5-FU(50.00%,P0.05).Apoptotic index(AI )was significantly higher(16.24%±3.21%as determined by TUNEL and 11.38%±6.46%by FACScan)in Sijunzi decoction treatment grou p than that in the control group(TUNEL:2.63%±1.03%,P0.01;FACScan:7.15%±1.32%,P0.05);while there was no significant increase of AI in 5-FU treatment grou p.Cell shrinkage,nuclear chromatin condensation,formation of membrane blebs andpop t o tic bod i es were fr equen tly observed on t u morsectionsin S ij un zi decoc ti on group whileon lyf ew apop t o ticce ll s/ bod i es and nec rotic ce lls were f ound in t he 5 2 FU tr ea t ment group and in con tr ol group cancer ce lls were in p roliferati on.Conc l usi ons The da ta de mons tr a t ed enhanced apop t os isin hu man gas tric cancerxenog raftsin nudemi ce a ft ertr ea t mentwith S ij un zidecoc ti on sugges ti ng t hatS ij un zidecoc ti on may be a po t en ti alan ti canceragentf orgas tric cancertr ea t men t.
【Fund】: 上海市教委青年基金项目98QV72
【CateGory Index】: R273
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