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《Chinese Journal of Cancer》 2001-04
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Study of Anticancer Effect of Hydroxycampothecin- based Combination against Experimental Nasopharyngeal Carcinoma

FU Li- wu*, LIANG Yong- ju, PAN Qi- chao Cancer Center, Sun Yat- sen University of Medical Sciences, Guangzhou 510060, P.R.China  
Objective: This study was designed to evaluate topoisomerase I inhibitor 10- hydroxycampothecin- based combination chemotherapy for nasopharyngeal carcinoma (NPC) in vitro and in vivo. Methods: Antitumor activity of 10- hydroxycampothecin (HCPT) in combination with 5- fluorouracil (5- FU) and/or cisplatin (DDP) in NPC cell line CNE2 and in CNE2 xenograft of nude mice were determined. The cytotoxicity was measured by MTT assay. Results: HCPT, 5- FU,and DDP had potential cytotoxicity to CNE2 cells. Their IC50 were 14.2μ mol/L, 17.2μ mol/L, 49.2μ mol/L,respectively. HCPT in combination with DDP had significant anticancer effect for NPC in vitro and in vivo. But no significant additivity or synergism was showed in the combination of HCPT with 5- FU in vitro and in vivo. HCPT+ DDP+ 5FU was much better than HCPT+ DDP for chemotherapy of NPC and the toxicity was endurable in the nude mice bearing CNE2 xenograft. Conclusion: HCPT+ DDP and HCPT+ DDP+ 5- FU were potential regimen for chemotherapy of NPC.
【Fund】: 国家自然科学基金项目!( NO.39770840)
【CateGory Index】: R739.63
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