Concomitant Cisplatin and 5- Fluorouracil with Veinal or with Oral High- Dose Leucovorin in Treatment of Patients with Advanced Nasopharygeal Carcinoma
LI Ping＊， ZHENG Jian, GUO Liang- jun, ZHUANG Cheng- hai Department of Oncology, the First Affiliated Hospital, Jinan University, Medical College, Guangzhou 510630， P.R.China
Objective： The aim of this study was to assess the efficacy and safety of veinal high dose Leucovorin＋ 5- FU and cisplatin regimen（ PFL1） and oral high dose Leucovorin＋ 5- FU and cisplatin regimen（ PFL2） in the treatment of the patients with reccurent nasopharyngeal carcinoma. Methods: From January 1997 to December 1999,53 cases of histologically proven advanced nasopharyngeal carcinoma were unrandomly divided into 2 groups, of whom 28 cases were treated with PFL1 regimen, 25 cases with PFL2 regimen. Results: Complete response rate and respose rates of PFL1 regimen and PFL2 regimen were 17.9％ , 64.3％ ,and 16％ , 56％ ,respectively. All the patients had been followed- up till December 1999. Thirteen patients died and fifteen patients survived and median remission duration was 10.5± 5.24 months(range,5－ 21 months) and median survival duration was 12.5± 5.13 months(4－ 35 month) of PFL1 group. Fourteen patients died and eleven survived and median remission duration was (9.3± 3.10) m (4－ 28 m) and median survival duration was(11.2± 3.66) m (4－ 28 m) of PFL2 group. There was no significant difference in complete response rate, respose rate, median remission duration and median survival duration between the two groups (P 0.05). PFL1 and PFL2 chemotherapy regimens for nasopharyngeal mass, metastasis of neck or abdomen lymphnode, metastasis of lung were effective; for metastasis of bone, the efficacy of releasing pain was good, but the response rate was unsatistactory; for metastasis of liver had no effect. The major toxicity included neucopenia， nausea， vomiting， mucositis et al.（ P 0.05） . Vein inflammation had significant differences between two regimens (P 0.05). Alepecia and pigmentation had very significant differences between two regimens (P 0.01). Conclusions: Veinal or oral high dose Leucovorin＋ 5- Fu＋ cisplatin were effective combinnation in the chemotherapy of nasopharyngeal carcinoma and the survival duration were longer.
【CateGory Index】： R739.63