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《Chinese Journal of Cancer》 2001-06
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Study on Improving the Techniques of Microwave Coagulation in Treatment of Patients with Large Liver Cancer

CHEN Jun-wei, LU Ming-de, XIE Xiao-yan, LIANG Li-jian, HUANG Jie-fu (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, P. R. China)  
Objective: The aim of this study was to improve the technique of percutaneous microwave coagulation therapy(PMCT) in the treatment of the patients with large liver cancers. Methods: The changes of temperature and coagulation area were measured in single and double irradiation for ex vivo liver tissue. Multiple irradiation schemes were devised by the aid of computer assistant design technique and verified by ex vivo experiment. Thermal monitor was conducted for 9 liver cancer cases with single irradiation and 4 cases with double irradiation. Multiple irradiation was applied for 16 liver cancer nodules ranging from 3 to 6 cm. Results: With 60 W × 300 seconds, single irradiation could create a coagulation area of 3. 0 cm in transverse diameter. The suitable distance of double irradiation was 2. 5 cm. Seven insertions could produce a spherical coagulation area of 7. 1 cm in diameter. Incomplete necrosis only occurred in 2 treated nodules. Conclusion: PMCT can completely ablate liver cancers about 6 cm by suitably prolonging the irradiation duration and using rational multiple insertion schemes.
【Fund】: 中山医科大学“211”工程重点学科项目(编号:98160);; 广东省医学科学技术研究基金项目(B2000030)
【CateGory Index】: R735.7
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