Fas Protein Expression and its Significance in Patients with Non-Hodgkins B Cell Lymphoma
SU Zu-lan, JIN Yi, TANG Lu-ying, WU Qiu-liang, ZHAO Mei-qing, FENG Zi-ying, SHAO Chun-kui ( Department of Pathology, the Third Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Cuangzhou 510630, P. R. China) ( Department of Pathology, Canc
Objective: The aim of this study was to investigate the distribution and the significance of Fas protein in subtypes of non-Hodgkin's B cell lymphoma (B-NHL), and to provide a new marker for observation and experimental evidence for diagnosis of the patients with B cell lymphoma. Methods: Fas protein expression in paraffin embedded sections of 79 cases conformed B-NHL and of 20 cases benign lymphoid tissue were determined by immunohistochemistry. Results: Fas protein expression was found in 65. 8% of B-NHL and 60. 0% of benign lymphoid tissue. There was no significant difference about quantity between B-NHL group and benign group(P 0. 05 ), but positive location of Fas protein is different. There were significant differences among three subtypes of B-NHL (P 0. 05). The expression of Fas protein in diffuse large B cell lymphoma (DLCL) was higher than that in follicular cell lymphoma(FCL) (P 0. 05) and also than that in small lymphocytic lymphoma (SLL) (P 0. 01 ). The expression of Fas protein in FCL was higher than that in SLL (P 0. 05). No significant correlation was found among Fas expression, sex, age, and tumor location (P 0. 05 ). Conclusions: There may be association in expression of Fas protein among subtypes and grades of B-NHL. The account of Fas expression is not useful for distinguishing benign from malignant groups, but it may be worthful to find locational characteristics of Fas protein in distinguishing benign and malignant lymphoid diseases. It should be valuable to detect quantity and distributuion of Fas protein in conform diagnosis of some difficult cases of B-NHL.
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