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《Chinese Journal of Cancer》 2001-08
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Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro

MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong  
Objective: To determine the anti tumor activity of glycyrrhiza uralensis Fisch in terms of apoptosis induction. Methods: Apoptosis was detected by fluorescence microscope and flow cytometry. Intracellular free Ca2+ and mitochondrial transmembrane potential (△Ψm) were measured by fluorescent probes Fluo 3 and Rh123, respectively. The expression of three proto oncogenes, c myc, c jun, and c fos,was examined by immunohistochemistry. Results: Glycyrrhiza uralensis Fisch extract selectively induced apoptosis in several human cancer cell lines, including MGC 803, HepG2, NSCLC, and Hela. Increase of intracellular free Ca2+ and decrease of △Ψm were observed in the apoptosis of MGC 803, HepG2, and NSCLC. Interestingly, glycyrrhiza uralensis Fisch extract couldn′t induce apoptosis in BGC-823, however, the changes of intracellular free Ca2+ and △Ψm were similar to that of apoptotic cell lines. The expression of c myc, c jun, and c fos in MGC 803 was elevated after the treatment. Conclusions: The anti tumor acitivity of glycyrrhiza uralensis Fisch is related to its ability of apoptosis induction in tumor cells. Increase of intracellular free Ca2+, decrease of △Ψm and the up regulation of c fos, c jun, and c myc protein expression take part in the regulation of apoptosis induced by the extract of glycyrrhiza uralensis Fisch.
【Fund】: 国家新药博士基金项目(No.96-901-06-36);; 广州市科委重点项目(No.97-Z-12-01)
【CateGory Index】: R73-36
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