Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2001-12
Add to Favorite Get Latest Update

Apoptotic Induction of Xinjiang Shikonin on Human Colorectal Cancer CCL229 Cell

JIANG Ying li, SONG Jin dan* Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, P.R.China  
Objective: To evaluate the apoptotic induction of Xinjiang Shikonin in human colorectal cancer cell line CCL229. Methods: MTT colorimetric assay was used to examine the growth inhibition of Xinjiang Shikonin in CCL229 cells. DNA agarose gel electrophoresis, flow cytometry analysis, and TUNEL test were performed to observe the apoptosis induced by Xinjiang Shikonin (0.1,1.0,10.0 μg/ml) in CCL229 cells. Results: 1.Xin Jiang Shikonin significantly inhibited the growth of CCL229 cells in a Concentration dependent manner. 2. DNA ladders, sub G1 peaks, and brownish yellow grains were observed by DNA agrose gel electrophoresis, flow cytometry, and TUNEL test,respectively, in CCL229 cells treated with Xinjiang Shikonin (1.0 μg /ml). Conclusion: Xinjiang Shikonin can induce apoptosis of human colorectal cancer CCL229 cells.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 HUANG He1,2, XIE Bing-Fen1,2, ZHU Xiao-Feng1,2, FENG Gong-Kan1,2, ZHOU Jun-Min1,2, WANG Yi1,2, WU Hai-Qiang3, HUANG Zhi-Shu3, GU Lian-Quan3, LIU Zong-Chao1,2 1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, 510060, P. R. China 2. Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510275, P. R. China;Antitumor Effect and Mechanism of Shikonin Derivative SYUNZ-7[J];Chinese Journal of Cancer;2005-12
2 CHEN Li-li1,CHEN Zhi-liang1,CHEN Feng1,M.James You2,CHEN Ling1,2(1.School of Life Science and Biotechnology,Shanghai Jiao Tong University,Shanghai,200240,China;2.University of Texas MD Andenson Cancer Center,Houston,TX77030,USA);Sishengsan's Inhibitory Effect on the Growth of A549 Cell Line and Its Acute Toxicity[J];Journal of Fudan University(Natural Science);2011-03
3 LI Li,LIANG Jing-yu*(Department of Natural Medicinal Chemistry,China Pharm-aceutical University,Nanjing 210009,China);Research progress on Arnebia Forssk.[J];Strait Pharmaceutical Journal;2009-04
4 GE Feng1, WANG Jian-ping1, LIU Di-qiu1, CHEN Chao-yin1, HANG Ben-yong1, WANG Yu-chun2(1.College of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650224, China;2.State Key Lab.Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China);Study on Interaction between Shikonin and Bovine Serum Albumin by Fluorescence Spectra[J];The Chinese Journal of Process Engineering;2009-01
5 ZHAO Rui-jie1,LI Yin-qian1,WANG Hui2,WANG Guang-bin2,GUAN Wei-jun2(1.College of Veterinary Medicine,Northwest Agriculture and Forestry University,Yangling 712100,China;2.China Institue of Animal Sicences,Chinese Academy of Agricultural Sciences(CAAS),Beijing 100193,China);Effects of shikonion the proliferation and apoptosis of hepatoma carcinoma cells[J];Heilongjiang Animal Science and Veterinary Medicine;2010-07
6 ;Progress research on colorectal cancer by combined TCM and west medicine[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2003-01
7 Chen ZhiLu,et al;Study on the apoptotic induction of shikonin on human leukemia K562 cells[J];Zhejiang Clinical Medical Journal;2007-08
8 Lin jiang,et al Clinical Laboratory, Luzhou Medical College Hospital;STUDY OF SUPPRESSION EFFECT OF XINJIANG SHIKONIN INHIBITOR ON THE GROWTH CANCER CELLS[J];Journal of Luzhou Medical College;2003-02
9 LU Hao,KANG-Jian (Deparment of Otorhinolaryngology,the First Hospital of Liaoning Medical College,Jinzhou 121001,China);Effect of Shikonin on human laryngeal cancer Hep-2 cells[J];Journal of Southeast University(Medical Science Edition);2011-02
10 HUANG He, LIU Zong-chao Research Department, Cancer Center, Sun Yat-sen University, Guangzhou 510060,P.R.China;Antitumor effect of shikonin and its derivatives[J];Journal of Qilu Oncology;2005-01
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Hu Yan-Ping, Wang Jun-Ye HuBei Cancer Hospital;INITIAL STUDY ABOUT RADIOSENSITIZING EFFECT OF SHIKONIN FOR MICE HEPATOMA 22 AND LEWIS LUNG CARCINOMA(LLC)[J];Cancer Research on Prevention and Treatment;1991-02
2 Lu Guirong Liao Jing, Beijing Institute for Cancer Research,Beijing (100034);The Detection of Anti-Cancer Biological Effect of Naphthoquinone Pigment-LⅢ[J];;1990-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG He1,2, XIE Bing-Fen1,2, ZHU Xiao-Feng1,2, FENG Gong-Kan1,2, ZHOU Jun-Min1,2, WANG Yi1,2, WU Hai-Qiang3, HUANG Zhi-Shu3, GU Lian-Quan3, LIU Zong-Chao1,2 1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, 510060, P. R. China 2. Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510275, P. R. China;Antitumor Effect and Mechanism of Shikonin Derivative SYUNZ-7[J];Chinese Journal of Cancer;2005-12
2 LI Li,LIANG Jing-yu*(Department of Natural Medicinal Chemistry,China Pharm-aceutical University,Nanjing 210009,China);Research progress on Arnebia Forssk.[J];Strait Pharmaceutical Journal;2009-04
3 HAN Jie1,2,WENG Xin-chu1,BI Kai-shun2(1.School of Life Sciences,Shanghai University,Shanghai 200444,China;2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,Liaoning,China);Antitumor Effects of Constituents from Lithospermum Erythrorhizon in Vitro[J];Fine Chemicals;2007-05
4 Chen ZhiLu,et al;Study on the apoptotic induction of shikonin on human leukemia K562 cells[J];Zhejiang Clinical Medical Journal;2007-08
5 Lin jiang,et al Clinical Laboratory, Luzhou Medical College Hospital;STUDY OF SUPPRESSION EFFECT OF XINJIANG SHIKONIN INHIBITOR ON THE GROWTH CANCER CELLS[J];Journal of Luzhou Medical College;2003-02
6 ZHAO Jing,ZHAO Wen ge,CHEN Hui (Department of Biology, Harbin Nomal Universiey,Harbin,150080,China);Research progress of apoptosis[J];Joural of Biology;2002-03
7 XU Kun-shan1,MENG Song-shu2(1.Taizhou Polytechnic Institute,Taizhou Jiangsu 225300,China; 2.Colloge of Biosci and Biotech,Yangzhou University,Yangzhou Jiangsu 225009,China);Research Progresses in Antitumor Activities and Mechanism of Shikonin and It's Derivatives[J];Journal of Taizhou Polytechnical Institute;2007-06
8 XU, De-Feng GUAN, Peng-Jian MAO, Zhi-Qiang LI, Shao-Shun* (School of Pharmacy, Jiaotong University, Shanghai 200030);Progress on Total Synthesis of Shikonin[J];Chinese Journal of Organic Chemistry;2005-07
9 LIU Liang-zhong,ZHANG Min,HUANG Jing,SHI Jia-yi1,PENG Guang-hua,ZHANG Sheng-hua (Lab. of Functional Food and Molecular Biology ,Hua Zhong Agricultural University, 1Life Science and Technology College, Chang Jiang University, Jinzhou 430070 China);EFFECTS OF CAROTENOIDS EXTRACTS FROM NATURAL RED YOLK ON PROLIFERATION AND APOPTOSIS OF HUMAN LIVER CANCER CELL[J];Acta Nutrimenta Sinica;2004-06
10 SUN Li-yun, DENG Bing-xu,CHEN Kai,et al(Department of Dermatology, The Traditional Chinese Medical Hospital of Beijing, Beijing 100010,China);Influence on Apoptosis of Zndirubin and Shikonin of Cultured Keratinocytes[J];The Chinese Journal of Dermatovenereology;2004-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 JIANG Jin-qing et al (College of Animal Science,Henan Institute of Science and Technology,Xinxiang,Henan 453003);Study on Enhancing the Cell Immunity of Broiler with Chinese Herbal Medicine[J];Journal of Anhui Agricultural Sciences;2006-18
2 ZHU Li-cheng et al (College of Life Sciences,Jinggangshan University,Jian,Jiangxi 343009);Study on the Anti-fungi Activity of the Extract from Three Kinds of Chinese Herb.[J];Journal of Anhui Agricultural Sciences;2006-21
3 MA Yan-fang(Department of Chemistry,Qinghai University for Nationalities,Xining,Qinghai 810007);Study on Antioxidative Effect of Lonicera Similis Hemsl[J];Journal of Anhui Agricultural Sciences;2007-11
4 ZHANG Xin et al(Faculty of Forestry and Biotechnology,Zhejiang Forestry College,Lin'an,Zhejiang 311300);Study on the Antibacterial Activity of Carya cathayensis Pericarp Extract[J];Journal of Anhui Agricultural Sciences;2010-04
5 HU Yong-jin et al (Faculty of Food Science and Technology,Yunnan Agricultural University,Kunming,Yunan 650201);Study on the Effects of Bacteriostasis in vitro of Cortex Moutan and Red Peony Root Extracts[J];Journal of Anhui Agricultural Sciences;2010-08
6 Zhang Buchang et al (Biology Dept,Anhui University,Hefei, 230039 );Study on extraction, purification and blood - sugar lowering of a polysaccharide from danpi (root shin of Paeonia suffruticasa Andr. )[J];JOURNAL OF ANHUI AGRICULTURAL SCIENCES;1995-04
7 LI Hai quan (Dept of Phar, The First Affiliospital of Anhui College of Traditional Chinese Medicine, Hefei 230031,China);Research of achyranthes bidentata polysaccharides on hypoglycemic effect in experimental diabetic mice[J];Anhui Medical and Pharmaceutical Journal;2004-05
8 YU Chao qin,CAI Zai long,YAN Yong bi,ZHANG Ya ni,PAN Rui ping,LING Chang quan (Dept.of TCM,Changhai Hospital,Second Military Medical University,PLA, Shanghai 200433,China);INHIBITORY EFFECT OF ALLICIN ON GROWTH OF HUMAN OVARY CANCER CELL LINE HO8910[J];Journal of Anhui Traditional Chinese Medical College;2001-06
9 BAN Chao,DAI Min,YAN Gui-ming(Department of Pharmacy,Anhui College of Traditional Chinese Medicine & Anhui key Laboratory for Modern Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effects of Combination of Medicinal Components of Cortex Moutan against Alcoholic Fatty Liver[J];Journal of Anhui Traditional Chinese Medical College;2009-05
10 ZHOU Lin, AI Zhong li, LIU Zhi su,et al Department of General Surgery of the Second Affiliated Hospital of Hubei Medical University, Wuhan 430071, P R China;An in vitro study of effect of Kushen compound preparation on human colon cancer cell line SW480[J];CHINESE JOURNAL OF CANCER;2000-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 HUANG Wei-wei,MENG Song-shu#,PAN Qin,WU Jian-fu,HU Mao-zhi,FAN Jian(College of Bioscience and Biotechnology,Yangzhou University,Yangzhou 225009,Jiangsu,China);Mechanisms of Shikonin-induced Apoptosis in JEG-3 Cells[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-06
2 HUANG Wen-hu et al (Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming,Yunnan 650224);Research Progress on the Biological Activities of Boraginaceae Secondary Metabolites[J];Journal of Anhui Agricultural Sciences;2010-28
3 ZHAO Yan-jing et al(Huaihai Institute of Technology,Jiangsu Ocean Biological Technology Key Construction Laboratory,Lianyungang,Jiangsu 222005);Study Progress of Phycocyanin Protein Biological Activity and Function Mechanism[J];Journal of Anhui Agricultural Sciences;2011-11
4 LI Ya-juan,HUANG Xiao-ping (Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,Shanghai 200040);Clinical and research advances of Arnebia euchroma in obstetrical and gynecological diseases[J];Anhui Medical and Pharmaceutical Journal;2011-06
5 Zhou Yuhong,Wu Dijiong,Shen Yiping,et al Traditional Chinese Medicine Hospital of Zhejiang Province,Hangzhou(310006);Overview the Treatment of Chronic Idiopathic Thrombocytopenic Purpura Based on Qi and Yin[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-05
6 CHEN Xiao-guang ZHU Bin ZENG Qi (Sichuan Vocational and Technical Collage,Suining 629000);Study on the Extraction Process of Shikonin from Sichuan Gromwell[J];Journal of Sichuan Vocational and Technical College;2008-04
7 LI Cui-fang1,WANG Fang1,MA Hao2,LUO Ming1,YU Yue-hua1 (1.College of Agronomy,Xinjiang Agricultural University,Urumqi 830052,China;2.College of Agronomy;Nanjing Agricultural University,Nanjing 210095,China);Study on antibacterial activity of Arnebia euchroma(Royle) Johnst hairy roots extract[J];Journal of Agricultural University of Hebei;2010-03
8 LUO Xue-ya, LI Ming-hui, L Li, LUO Yuan-li, ZHANG Ning (Medical College, Dalian University, Dalian 116622,China);Research progress of pharmacological action and application of lithospermum erythrorhizon Sieb. et Zucc.[J];Journal of Dalian University;2004-02
9 Ding Lin-ting,Feng Xiao-ling,Zhang Su-bing,et al. (First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China);The Clinical Study and Treatment of Gongbao Power on Cervical Precancerous with HPV Infection[J];Chinese Journal of Medicinal Guide;2011-05
10 LI Cui-fang1,LI Xin-ren1,WANG Fang1*,MA Hao2,HE Jin-hua3,YU Yue-hua1(1 College of Agronomy,Xinjiang Agricultural University,Urumqi 830052,China;2 College of Agronomy,Nanjing Agricultural University,Nanjing 210095,China;3 Institute of Pharmacology of Xinjiang,Urumqi 830004,China);Analysis on Content of Total Sugar and Polysaccharides from Arnebia euchroma(Royle) Johnst Hairy Roots[J];Acta Botanica Boreali-Occidentalia Sinica;2010-01
China Proceedings of conference Full-text Database 3 Hits
1 Li Jing, Wang BingXiang,Gong Meijuan, Luo Peng, Du Jiang Yan (Department of Chemistry and Environmental Science, Nanjing Normal University, 210097);Study of Interaction between Indolizine-naphthoquinones and CT-DNA by cyclic voltammetry[A];[C];2005
2 Jing Li, Mei-Juan Gong, Bing-Xiang Wang, Jiang-Yan Du * College of Chemistry and Environmental Science, Nanjing Normal University, 210097, Nanjing;Study of Interaction between Indolizine-naphthoquinones and CT-DNA by cyclic voltammetry[A];[C];2006
3 Xiaopo Zhang~(1,4),Yuehu Pei~3,Junqing Zhang~1,Xudong Xu~4,Yinfeng Tan~1,Shengli Kang~1, Mingsheng Liu~(2*) (1.School of Pharmaceutical Science,Hainan Medical University,Haikou,571101;2.Hainan provincial institute of Sourth and Li medicine Development,Haikou,571101;School of Materia Mdeica,Shenyang Pharmaceutical University,Shengyang,110016;4.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,100193);Research progress on chemical constituents and pharmacological activities of Hibiscus tillisceus[A];[C];2011
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved