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《Chinese Journal of Cancer》 2002-01
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Matrix Metalloproteinase-2 and Angiogenesis in Gastric Cancer

CAI Hua*, KONG Zhao ru, CHEN Hong-meiHospital of the Chinese peoples Armed Police Anhui Province Force, Hefei 230041, P.R.China  
Background Objective: The proliferetion and metastasis of solid tumor depend on angiogenesis. Experiment study showed that matrix metalloproteinase-2(MMP-2) may play an important role in angiogenesis of solid tumor. The current study was designed to explore the role and the significance of MMP-2 on angiogenesis in gastric cancer through observing the relationship between the expression of MMP-2 and microvessel density (MVD) in gastric cancer tissues, paracancerous tissues, and incisal margin normal tissues. Methods: A total of 50 specimens resected was investigated by S-P immunohistochemical staining with a anti-MMP-2 monoclonal antibody and a monoclonal antibody against FⅧRAg. The expression of MMP-2 and MVD in various regions of the gastric cancer tissues, paracancerous tissues and incisal margin normal tissues were detected and the relationship between the expression of MMP-2 and MVD, as well as their relationship with clinicopathologic factors were analyzed. Results: The expression of MMP-2 negative or low in normal tissues. The high expression of MMP-2 in cancer tissues was significantly higher than in the paracancerous tissues (64.0% vs 28.0%, χ2=7.48, P 0.01 ). The low expression of MMP-2 in paracancerous tissues was significantly higher than in the normal tissues ( 52.0% vs 26.0%,χ2=6.18, P 0.05 ). The MVD in the cases with the high expression of MMP-2 was significantly higher than in those with the low expression of MMP-2 in cancer tissues and paracancerous tissues (30.71±7.41 vs 26.15±4.82,t=2.11,P 0.05; 15.31±5.23 vs 9.61±2.17,t=3.98, P 0.01 ). Moreover, the high expression of MMP-2 (81% vs 51.7%,χ2=4.67, P 0.05; 87.0% vs 44.4%,χ2=9.47, P 0.01; 81.8% vs 50.0%,χ2=5.41,P 0.05; 89.5% vs 48.4%,χ2=8.63, P 0.01 ) and its MVD (28.89±5.37 vs 25.21±5.37,t=2.39,P 0.05; 27.84±2.32 vs 25.12±3.45, t=2.02,P 0.05 ; 28.63±3.12 vs 25.53±4.23,t=2.87,P 0.01; 28.84±2.64 vs 25.31±4.35, t=3.09,P 0.01 ) in cancer tissues were significantly related with the serosal invasion, grade of differentiation, lymph node, and liver metastasis(P 0.05-0.01 ). Conclusions: The high expression of MMP-2 was significantly associated with MVD, biological behaviors of gastric cancer tissues, MMP-2 might be one of the important factors in the angiogenesis of gastric cancer.
【Key Words】： Stomach neoplasms Angiogenesis Matrix metalloproteinase-2 lmmunohistochemistry
【CateGory Index】： R735.2
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