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《Chinese Journal of Cancer》 2002-03
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Expression of HIF-1αand Its Relationship to Apoptosis and Proliferation in Lung Cancer

FAN Li-fang * ,DIAO Lu-ming,CHEN De-ji,LIU Ming-qiu,ZHU Li-qin,LI Hong-gang,TANG Zhi-jiao,XIA Dong ,LIU Xuan,CH EN Hong-lei Department of Pathology,Medical Co llege,Wuhan University,Wuhan 430071,P.R.China  
Background Objectives:Hipoxia-inducible factor-1is a tra nscriptive factor that regulates ge nes involved in metabolism,angiogenesis,proliferation,and apoptosis.This study was designed to investigate the expr ession of hypoxia inducible facter-1alpha(HIF-1α)and its relationship to bcl-2,Bax,PCNA in lung cancer.Method:Immunohistochemical streptavidin /peroxidase(SP)was used to examine the expression of HIF-1a,bcl-2,Bax,and PCNA in 60cases of lung cancer.Results:In 60cases of lung cancer,postive ra te for HIF-1a was 28.3%(17/60),specially the postive rate of small cell lung cancer(66.7%)was significantly higher than non-s mall cell lung cancer(21.6%).HIF-1a expression increased as clinical stage and meta stasis increased(P 0.01).The positive rate of bcl-2,Bax,and PCNA were 31.7%(19/60),40.0%(24/60),76.7%(46/60),respectively.Inverse relationsh ip was found between the expression o f HIF-1αand bcl-2;while the correlation of H IF-1αand Bax was positive(P0.01).The relationship between HIF-1αand Bax was postive(P0.01).The relationship between HIF-1αand PCNA was not observed(P0.05).Conclusion:HIF-1αis correlated with apopotosis,but has no relation ship with proliferation.
【Fund】: 国家自然科学基金资助项目(编号39870305);; 湖北省教委重点项目(编号97A050)
【CateGory Index】: R734.2
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