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《Chinese Journal of Cancer》 2002-04
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Matrine Affects Early Expression ofProto-oncogenes in K562 Cells

HE Yu juan*,JIANG Ji kai,OU Yi heng,LIU Bei zhong,LIU Xiao shan,ZHANG Yan,MA Lin di,TU Zhi guangDepartment of Clinical Bio chemistry,Chongqing University of Medical Sciences,Chongqing 400016,P.R.China  
Background Objective: It has been reported that matrine had the anti tumor activity, and our previous study have provided that matrine had the effects of inhibiting proliferation and inducing differentiation in K562 cell line, but its molecular mechanism is unknown yet. Method: The expression of several proto oncogenes(c myc,c jun,H ras,p21,and HNF 1α) in K562 cell line treated by 0.2 mg/ml matrine were measured by RT PCR. Result: The c myc, c jun,and HNF 1αmRNA of K562 cells treated by 0.2 mg/ml matrine were dramatically decreased at the early stage (3 h), while the H ras and p21 mRNA were increased obviously at the same time. Conclusion: The changes of several proto oncogenes in K562 cells treated by 0.2 mg/ml matrine may be related to inhibiting proliferation and inducing differentiation.
【Fund】: 国家自然科学基金项目(No:39670881;30171150)
【CateGory Index】: R73-36
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