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《Chinese Journal of Cancer》 2002-08
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Clinical Study on Patients with Adva nced Gastric Cancer Treated with Oxaliplatin Combining with Hyd roxycamptothecine

YANG Chun-xu ,HUANG Hai-xing,LI Gui-sheng Department of Oncology,The Fourth Affiliated Hospital,Guangxi Medica l University,Liuzhou 545005,P.R.China  
Background and Objective:Internal and external physiological research showed oxaliplatin could obviously suppress several kinds of tumors in c ombination with most anti-cancer dr ugs and help these drugs to kill the tu mor cells.This study was designed to investigate th e initial curative effects and tolerance of patients with advanced gastr ic cancer of treatment with combination of oxaliplatin(L-OHP)and hydroxycamptothecine(HCPT).We compared this treatment with tra ditional chemotherapy.Methods:In a non-randomized manner,43patie nts with advanced gastric cancer were divided into treatment group(L-OHP plus HCPT)and control group(VP- 16 +CF +5-FU)(ELF).Among these patients,28were male a nd 15were female.The median age was 59.Karnofsky performance status(KPS)scale was more than 60.We compared th e initial curative effects and tolerance betw een these two groups.Results:The beneficial effects for the treatment group(24cases)and control group(19cases)were 58.3%(14/24)and 42.1%(8/19),respectively.Obviously,the beneficial effects to the treatment group were higher than that of the control group(P0.05).The side effects of both groups included bone marrow suppression,nausea,vomiting,stomatitis,neuritis,phlebiti s,hair loss,and so on.But they were s light (withinⅠandⅡdegree).Conclusions:The use of L-OHP plus HCPT appears to b e a very good treatment for patients with advanced gastric cancer.The patients can tolerate the side effects.
【CateGory Index】: R735.2
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