Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2002-11
Add to Favorite Get Latest Update

Expression and Clinical Significance of IGF-Ⅱ mRNA and Bcl-2 Protein in Colorectal Adenocarcinomas

ZHANG Ming sheng1*, YUAN Hong yin1, XIONG Bin1, DENG Qin1, TANG Zhi jiao2, XIA Dong21.Department of Oncology, Zhongnan Hospital of Wuhan University,Wuhan 430071, P.R.China2.Department of Pathology,Medical College, Wuhan University, Wuhan 430071,  
Background Objective: Insulin like growth factor Ⅱ (IGF Ⅱ) can stimulate cell proliferation; B cell lymphoma 2 (bcl 2) protein can strongly inhabit cell apoptosis. Recently, the overexpression of IGF Ⅱ and bcl 2 in colorectal cancer has been found,but the combined detection of them has not been reported. The objective of this study was to investigate the relationship between the expression of IGF Ⅱ, bcl 2 and the invasion,metastases of colorectal adenocarcinomas and to analyze the clinical significance of combined detection of these factors. Methods: Forty eight paraffin embedded samples from colorectal adenocarcinomas were selected. IGF Ⅱ mRNA was detected by using in situ hybridization. The expressions of bcl 2 and PCNA protein were determined immunohistochemically,and TUNEL technique was used to detect apoptosis. Ten normal colorectal tissues were used as controls. The positive cell ratio of cancers was calculated by computer. The specimens with positive cell ratio ≤30% were defined as negative. Results: The expressions of IGF Ⅱ mRNA and bcl 2 protein were significantly higher in colorectal adenocarcinomas (38.70%±7.80% and 30.97%±7.40%) than in normal colorectal tissues(23.12%±4.07% and 12.69%±1.31%)(P 0.01) and were related to Dukes′ stage and lymph node metastases but were not associated with patient′s age, gender, tumor site, tumor size and umor differentiation. A negative correlation was observed between IGF Ⅱ mRNA and bcl 2 protein (P 0.05). A positive correlation between IGF Ⅱ mRNA and PCNA, apoptosis as well as a negative correlation between bcl 2 and apoptosis were observed (P 0.01).There was no correlation between bcl 2 and PCNA (P 0.05). The patients with IGF Ⅱ mRNA (+) and bcl 2 ( ) were regarded as the worst prognosis. Conclusion: The overexpression of IGF Ⅱ and bcl 2 in colorectal adenocarcinomas play an important role in the pathogenesis,progression, invasion, and metastases of the tumor. Determination of both IGF Ⅱ and bcl 2 expression would be helpful for decision making of adjuvant therapy.
【CateGory Index】: R735.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 WU Dan,SHEN Huan,TIAN Li.(Reproduction Center,Peking University People's Hospital,Beijing 100044,China);Expression of protein IGF-I and Bcl-2 in endometrium in PCOS patients with insulin resistance[J];Chinese Journal of Clinical Obstetrics and Gynecology;2009-05
2 SONG Xiaohua,HE Yanxin,ZHENG Yinglan(Qingdao Central Hospital,Shandong Qingdao 266042,China);Expression and Clinical Significance of Insulin-like Growth Factor-Ⅰand Insulin-like Growth Factor-Ⅱ in Gastric Cancer[J];Hebei Medicine;2010-06
3 WU Hui1,CHEN Kui-sheng2 1.Department of Radiation Oncology,Henan Tumor Hospital,Zhengzhou 450008,P.R.China 2.Department of Pathology,College of Medicine,Zhengzhou University,Zhengzhou 450052,P.R.China;Expression and correlation of IGF-Ⅰ and IGF-IR in esophageal squamous cell carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-11
4 Guo Baowen,Wu Minlan,Yang Lin;Expression of IGF-Ⅱ and IGF-ⅠR in colorectal cancer[J];Shandong Medical Journal;2005-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHU Yong_mei,ZHONG Jin_yi ˇ ,ZHANG Li_hua (Institute of Nutrition,Medical College of Qingdao University,Qingdao266021,Shandong,China);The Effect of HPP on Abnormal Expression of Mice Hepatic Cells POD and Caspase-3[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-04
2 WANG Yi-pei1,2,LI Xiao-nuan1,LAI Rui-ping1,YU Ri-an3,LU Wen-qing1,(1.Department of Occupational and Environmental Health,MOE Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China);The Antagonism of Selenium on Arsenic-induced Cell Cycle Changes by Activator Protein-1 Regulation[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-03
3 XU Jia1,ZHANG Yin-juan2,LU Gang3,SHAN Bao-en3,(1.School of Medicine in Biochemistry,Ji'nan University Guangzhou,510632;2.Clinical Laboratory,People's Hospital of Linfen City,Linfen 041000,Shanxi;3.Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China);Effects of RNAi Targeted to STAT3 on Apoptosis Induction and on STAT3 Signaling in Human Hepatocellular Carcinoma Cells[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-05
4 ZHU Guo-qi,TANG LI-jian,WANG Lei,SU Jing-jing,WANG Ning,PENG Dai-yin,LI Qing-lin(Anhui College of Traditional Chinese Medicine & Anhui Key Laboratory of Modern Chinese Materia Medica,Anhui Hefei 230038,China);Study on Baicalin Induced Apoptosis of Human Breast Cancer Cell Line MDA-MB-231[J];Journal of Anhui Traditional Chinese Medical College;2008-02
5 ZHAO Xin, SONG Jin dan*Key Laboratory of Cell Biology,Ministry of Public Health of China,China Medical Unviersity,shenyang 110001,P.R.China;Clotrimazole Induced Apoptosis in Human Colon Cancer Cell Line CCL229[J];Chinese Journal of Cancer;2002-06
6 Li Jin Quan1,Chen Rui Chuan2,Cai Ke Xia2,Ye Zhi Yun11.Department of Biology,2. Cancer Research Center,Life Science School of Xiamen University, Xiamen, Fujian, 361005, P.R.China;Apoptosis of Human Gastric Cancer Cell Induced by Photochemical Riboflavin[J];Chinese Journal of Cancer;2003-03
7 LIANG Tong, CHEN Mei-Jun, ZHOU Ke-Yuan, TANG Xu-Dong, WANG Xu-Guang Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang,Guangdong,524023, P.R.China;Induction of Apoptosis in Human Nasopharyngeal Carcinoma Cell Line CNE-2Z by Curcumin[J];Chinese Journal of Cancer;2004-12
8 YAN Xiao-Jian1,2, LIANG Li-Zhi1,2, ZENG Zong-Yuan1,3, SHI Zhi1,4, FU Li-Wu1,41. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China2. Department of Gynecology, Cancer Center,Sun Yat-sen University,Guangzhou, Guangdong, 510060, P. R. China2. Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China3. Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Effect of Survivin shRNA on Chemosensitivity of Human Ovarian Cancer Cell Line OVCAR3 to Paclitaxel[J];Chinese Journal of Cancer;2006-04
9 XU Xue-ping,WANG Lei,JIANG Jin-peng(College of Animal Science,Anhui Science and Techology University,Fengyang 233100,China);Biological Law of Animals' Muscle Growth[J];Journal of Anhui Science and Technology University;2010-06
10 MEI Chuan zhong,SHEN Ji long,CHEN Yong,LI Bai qing (Department of Microbiology and Parasitology,Anhui Medical University,Hefei,Anhui 230032,China);Apoptosis of γδT cells and αβT cells induced by ceramide[J];Journal of Bengbu Medical College;2004-03
China Proceedings of conference Full-text Database 1 Hits
1 Yang Ruirui Feng Feng Guo Hongyu (Beijing Sport University,Beijing 100084);Ubiquitin Proteasome Pathway and Skeletal muscle Apoptosis in Exercises[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Qing, KONG Xian guo, HAO Jie min, et al. Department of General Surgery, Railway Hospital, Shanghai Tiedao University,Shanghai 200072,P.R.China;Expression of IGF-I mRNA in colorectal carcinomas and its relationship with the presence of metastasis[J];CHINESE JOURNAL OF CANCER;2000-02
2 Xie Qing-Xiang1,Lin Xia-Cong1,Zhang Min-Feng2,Han Cong-Xiang1,Guo Yi-He 2 1.Department of Urology,The 175th Hospital of PLA,Zhangzhou,Fujian,363000,P.R.China 2.Department of Pathology,The 175th Hospital of PLA,Zhangzhou,Fujian,363000,P.R.China;Expression of IGF-Ⅰand IGF-ⅠR in Bladder Cancer[J];Chinese Journal of Cancer;2004-06
3 WANG Xiaofeng, JIANG Hui, YE Haiyun, XU Qingquan, ZHU Jichuan, Hou Shukun (Department of Urology, People's Hospital, Beijing Medical University, Beijing 100044);EXPRESSION OF bcl 2 mRNA IN NORMAL AND HYPERPLASTIC PROSTATE TISSUES[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1998-06
4 ZHANG Ming-sheng, ZHOU Yun-feng, HU Ai-hua. Department of Tumor Radio-chemotherapy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;IGF-Ⅱ Promotes the Proliferation and Apoptosis of Human Colorectal Adenocarcinomas and Its Clinical Significance[J];Journal of Chinese Physician;2005-01
5 LIU Hai feng, LIU Wei wen, FANG Dian chun, WANG Guo an, TENG Xiao chun, CHEN Gang (Gastroenterology Research Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Expression of bcl-2 gene in gastric carcinoma and precancerous lesions and its regulatory role in apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2004-07
6 L Yong Gang, DOU Ke Feng Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Expression and significance of insulin-like growth factor Ⅱ and its receptor in liver tissue[J];Journal of The Fourth Military Medical University;2002-14
7 Zhang Junmei, Zhou Rong, Yang Datong, et al.(Department of Obstetrics and Gynecology, Haidian Hospital, Beijing 100080, China);Insulin-like growth factor-1 receptor expression and their clinical significance in endometrial adenocarcinoma[J];Chinese Journal of Clinical Obstetric and Gynecology;2005-05
8 Qi Falian, Xu Jun, Du Xiumin et al Department of Medieal Laboratory, General Hospital of Jinan Military Region, Jinan (250031);Levels and Clinical Significance of Serum IGF-Ⅱ in Patients with Five Kinds of Malignant Tumors[J];Journal of Radioimmanology;2002-05
9 SUN Chen yi,PAN Yao zhen,WANG Yu zhi.Department of General Surgery,Affiliated Hospital,Guiyang Medical College,Guiyang 550004,China);INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR EXPRESSION AND SIGNIFICANCE IN HUMAN PANCREATIC CANCER CELLS[J];Journal of Hepatobiliary Surgery;2003-04
10 WU Yiping, Derek LeRoith, Shoshana Yakar Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, NIDDK, National Institute of Health, Bethesda MD 20892-1758, USA;Histological Features of Primary Mammary Tumor in LID Mice In- duced by 7, 12-Dimethybenz (a) Anthracene[J];Foreign Medical Sciences;2004-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 MAO Hai-xia~(1,2),CHEN Hong~(1,3),ZHANG Chun-lei~(1,3),ZHANG Zheng-feng~1,LEI Chu-zhao~1,LAN Xian-yong~1,WANG Ju-qiang~4 (1.College of Animal Science and Technology,Northwest A&F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling,Shaanxi 712100,China; 2.College of Life Science,Shanxi Normal University,Linfen,Shanxi,041000,China; 3.Institute of Cellular and Molecular Biology,Xuzhou Normal University,Xuzhou,Jiangsu 221116,China; 4.The Research Center of Cattle Engineering Technolog in Henan,Zhengzhou,Henan 450003,China);Association of Polymorphism of IGF2 Gene with Growth Traits in Jiaxian Red Cattle[J];China Cattle Science;2008-02
2 YAN Shuai,LI Xiao-hua,PENG Yong-de (Department of Endocrinology,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China);Polycystic ovary syndrome and insulin resistance[J];World Clinical Drugs;2010-02
3 SONG Xiaohua,HE Yanxin,ZHENG Yinglan(Qingdao Central Hospital,Shandong Qingdao 266042,China);Expression and Clinical Significance of Insulin-like Growth Factor-Ⅰand Insulin-like Growth Factor-Ⅱ in Gastric Cancer[J];Hebei Medicine;2010-06
4 XIE Yang1,WU Xiao-tao2(1.School of Clinical Medicine,Southeast University,Nanjing 210009,China;2.Department of Orthopaedics,Zhongda Hospital,Southeast University,Nanjing 210009,China);Expression and biological significance of IGF-I and IGF-IR in human degenerative intervertebral discs[J];Journal of Southeast University(Medical Science Edition);2010-02
5 WU Hui1,CHEN Kui-sheng2 1.Department of Radiation Oncology,Henan Tumor Hospital,Zhengzhou 450008,P.R.China 2.Department of Pathology,College of Medicine,Zhengzhou University,Zhengzhou 450052,P.R.China;Expression and correlation of IGF-Ⅰ and IGF-IR in esophageal squamous cell carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-11
6 HE Jing-jing1,HUANG Tian1,LIU Li1,XIANG Hao1,LIU Li1,XU Yi-hua1,WEI Sheng1,ZHANG Xiao-xiao1,CHEN Ji-gui2,WANG Qian2,LIU Chang2,NIE Shao-fa1 1.Department of Epidemiology and Statistics,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China 2.Department of Colorectal Surgery,NO.8 Hospital of Wuhan,Wuhan 430010,P.R.China;IGF-ⅠR,IGF-Ⅰand IGF-Ⅱ expressions in colorectal cancer and their roles[J];Chinese Journal of Cancer Prevention and Treatment;2008-13
7 LU Xiang,HAN Wen-lan,WU Wan-xin,YU Qi-xia,CHEN Cai-ping,GUO Wen-liFirst Hostpital of Jiaxing,Jiaxing 314000,P.R.China;Expression of insulin-like growth factor-Ⅰ receptor in breast cancer[J];Chinese Journal of Cancer Prevention and Treatment;2010-06
8 WU Jin-bao,NAN Qing-zhen,ZHANG Shao-rong,ZHANG Di,ZHANG Zhen-shu,SONG Yu-gang* (Nanfang Hospital,Southern Medical University,Guangzhou 510515,P.R.China);Significance and mechanisms of overexpression of PAK1 gene in colorectal carcinoma cells[J];Shandong Medical Journal;2007-29
9 ZHAO A-hong1,WANG Yong-xia,LI Dao-ming,LI Hai-mei,ZHAO Zhi-hua(1 the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,P.R.China);Expression and significance of the HIF-1α and IGF-1 protein in esophageal squamous cell carcinoma tissues[J];Shandong Medical Journal;2007-29
10 FEI Bo-jian, WU Lu-lu, ZHOU Shi-fu, QI Xiao-wei (Department of General Surgery, The Fourth People’s Hospital of Wuxi, Wuxi 214062, Jiangsu, China) Corresponding author: ZHOU Shi-fu;Expression and significance of IGF-Ⅰ, IGF-ⅠR in colorectal carcinoma[J];Biomedical Engineering and Clinical Medicine;2009-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved