Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2003-12
Add to Favorite Get Latest Update

Effect of Allitridi on Cyclin D1 and p27~(Kip1) Protein Expression in Gastric Carc inoma BGC823 Cells

Lan Hong, Lu You-Yong Beijing Laboratory of Molecular Oncology,Beijing Institute for Cancer Research,School of Oncology, Peking University, Beijing,100034, P.R.China  
BACKGROUND OBJECTIVE: Previous study showed that allitridi mar ke dly suppresses cellular proliferation, blocks cell cycle at G1 phase, and induce s cell apoptosis of human gastric cancer BGC823 cell. During the investigation o f its molecular mechanisms and target genes, the authors found that protein expr ession of cyclin D1 and p27Kip1 play an important role in an allitridi-induced G1 arrest. This study was designed to explore the effect of allitridi on the exp ression of cyclin D1 and p27Kip1 in BGC823 cells. METHODS: After total RNA and t otal protein in allitridi-treated (25 μg/ml) and allitridi-untreated BGC823 c ells were abstained, Western blot analysis was performed to determine the protei n levels of cyclin D1 and p27Kip1, and RT-PCR was performed to determine the mR NA levels of cyclin D1 and p27Kip1. RESULTS: After treated with 25 μg/ml allitr idi for 24 hours, the protein levels of cyclin D1 of BGC823 cells were downregul ated and the protein levels of p27Kip1 were upregulated, and this changes were m ore obvious after 48 hours,while their mRNA levels remained unchanged.CONCLUSION :Allitridi may influence the protein expression of cyclin D1 and p27Kip1 in BGC8 23 cells, while do not influence their mRNA transcription.
【Fund】: 国家重点基础研究发展规划项目(No.98031200);; 国家自然科学基金(No.39625016)
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 ZHANG Yu,SHAO Shu-li*(School of Life Science and Engineering,Qiqihar University,Qiqihar 161006,China);The pharmacological effect of allium[J];Journal of Science of Teachers' College and University;2007-01
2 LIU Yang-qing,GAO Yong,WAN Yi-yuan,YI Zhu-jun,HUI Hong-xia,XU Li-juan,LIU Hua.Department of Oncology,Affiliated Huai'an Hospital of Nanjing Medical University,Huai'an 223300,China;Effect of allicin on proliferation of colon cancer LoVo cell line in vitro[J];Chinese Clinical Oncology;2009-02
3 ZHAO Xiao-dan1,HU Xiao-song2(1. College of Forestry,Northeast Forestry University,Harbin 150040,China;2. College of Food Science of Nutritional Engineering,China Agricultural University,Beijing 100083,China);Study on inhibitory effect of pickled garlic extracts on certain cancer cell lines[J];Science and Technology of Food Industry;2008-10
4 LV Yan-xin,LI Wei,YAN Yun-qin.Biological Sciences Institute,Northeast Agricultural University,Haerbin 150030,China.;The effect of allicin on inducing tumor cells apoptosis.[J];Journal of Modern Oncology;2006-01
5 HU Yu-xi1,2,CHEN Xi1,LIU Qing-fei1, XU Mu3,WANG Yi-ming1,3, LUO Guo-an1(1.Institute of Biomedicine,Tsinghua University,Beijing 100084,China;2.Department of Pharmacy,Jiangxi College of Traditional Chinese Medicine,Nanchang 330006,China;3.Zhuhai R&D Center for Biomedical Pharmaceutics,Zhuhai 519085,China);Recent Advances in Study of Pharmacological Action of Garlicin[J];Progress in Pharmaceutical Sciences;2007-11
6 Anna HERMAN-ANTOSIEWICZ~(2,3),Anna A POWOLNY~(2,4),Shivendra V SINGH~(4,5)~3 Department of Molecular Biology University of Gdask,Kladki 24,80-822 Gdask,Poland;~4 Department of Pharmacology and Universityof Pittsburgh Cancer Institute,University of Pittsburgh School of Medicine,Pittsburgh,Pennsylvania 15213,USA;Molecular targets of cancer chemoprevention by garlic-derived organosulfides[J];中国药理学报(英文版);2007-09
7 ZHU Gui-jun,HU Zhen-jie,YU Zhan-biao,et al.Intensive Care Unit,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Effect of allicin on mice with acute lung injury induced by lipopolysaccharide[J];Chinese Journal of Critical Care Medicine;2005-10
8 ZHAO Jie,MAO Xiao-jian,ZHAO Jia-tao,et al.Yunnan College of TCM Kunming 650200,China;Study on the Anti-Gastric Carcinoma Mechanism of Garlic[J];Chinese Journal of Modern Drug Application;2008-02
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 GAO Xue, SUN Yuan, HUANG Lei, CHEN Xiao-Yan, ZHANG Kai-Li, KONG Qing-You, LIU Jia, LI HongCancer Institute/Liaoning Provincial Key Lab of Cancer Genomics,College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116027, P.R.China;Down-regulation of Caveolin-1 in Gastric Carcinoma and Its Clinical Biological Significance[J];Chinese Journal of Cancer;2005-03
2 GAO Fulian 1,2),YUE Baohong 1,3),MA Kaiyan 1),LE Xiaoping 1),ZHANG Qinxian 1) 1)Molecular Cell Biology Research Center, College of Basic Medical Sciences, Zhengzhou University; Henan Key Laboratory of Molecular Medicine, Zhengzhou 450052 2)Department of Histology and Embryology, Xinxiang Medical College, Xinxiang 453003 3)Clinical Labroatory, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Expression of multidrug resistance gene 1 and P-glycoprotein in GSE 1 cell, BGC823 cell, and SGC7901 cell[J];Journal of Zhengzhou University(Medical Sciences);2006-03
3 Feng Liyun et al (Department of Biology);Cytogenetic and Molecular Cytogenetic Studies of Gastric Cancer Cell Lines[J];JOURNAL OF HARBIN MEDICAL UNIVERSITY;1998-03
4 Ru Xiangbin; Wei Changhua; Cheng Junping; Feng Xingwan; Lin Yongqi(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850);Experimental antitumor activity of taurine gossypol and harbital gossypol[J];BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES;1995-02
5 XI Sheng-yan1,ZHANG Qian1,LIU Chao-yang2,SUN Hong-mei1,GE Gui-ling1,CUI Wei3,XIE Hua1,LIU Lin-tao1,GAO Xue-min1(1 School of Fundamental Medicine,Beijing University of Chinese Medicine,Beijing100029; 2 Institute of Oncology,Tumor Hospital,Chinese Academy of Medical Sciences; 3 Dongzhimen Hospital,Beijing University of Chinese Medicine);Inhibitory effect of hydroxy saffloryellow-A on transplantation tumor of human gastric adenocarcinoma cell line BGC-823 in nude mice[J];Journal of Beijing University of Traditional Chinese Medicine;2009-05
6 WANG Yu-qiao,HAN Mei,HOU Xiao-li.Department of Microbiology and Immunology of Ningxia Medical College,Yinchuan Ningxia 750004,China.;Comparison of proliferation and invasion among four human gastric cancer cell lines in vitro.[J];Journal of Clinical and Experimental Medicine;2006-10
7 LI Qi fu, LI Chang you, OUYANG Gao liang, YE Jun, LI Xiao quan, HONG Shui gen (Lab. of Cell Biol. college of Life Science, Xiamen Univ., Xiamen 361005, China);The Inhibition Effect of Tachyplesin on the Proliferation of Human Gastric Carcinoma Cell Line BGC-823[J];Journal of Xiamen University(Natural Science);2001-01
8 Wei Qisheng, Wu Chutse (Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850);EXPERIMENTAL STUDIES ON A LOW MOLECULAR WEIGHT TUMOR SUPPRESSOR FROM HUMAN FETAL BRAIN[J];Chinese Journal of Applied Physiology;1992-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Deng Dajun, Zhang Li, Guan Jiuping, Zhou Jing, Zhang Rufu Beijing Institute for Cancer research, Beijing 100034;MODULATION OF MUTAGENICITIES OF N-NITROSAMIDES BY GARLIC[J];Carcinogenesis,Teratogenesis and Mutagenesis;1993-04
2 Luo yang,Wu Gengshu, Zhang Liyan,et al Shenyang Medical College, Shenyang, 110031;EXPERIMENTAL RESEARCH ON EFFECT OF ALLITRADI ON IMPROVING GJIC AND ANTI OXIDATION[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-06
3 ZHANG Lei et al(School of Food Science and Technology,Southern Yangtze University,Wuxi,Jiangsu 214036);Study on Physical Characteristics of Fish Meal with Different Particle Size[J];Journal of Anhui Agricultural Sciences;2007-32
4 Sun ChuanhongDepartment Of Oral Surery,An Qing No1 People Hospital,An Qing,246003;A comparision of the clinic effects in three types intracanal disinfectant medicament[J];Anhui Medical Journal;2007-03
5 YU Chao qin,CAI Zai long,YAN Yong bi,ZHANG Ya ni,PAN Rui ping,LING Chang quan (Dept.of TCM,Changhai Hospital,Second Military Medical University,PLA, Shanghai 200433,China);INHIBITORY EFFECT OF ALLICIN ON GROWTH OF HUMAN OVARY CANCER CELL LINE HO8910[J];Journal of Anhui Traditional Chinese Medical College;2001-06
6 PAN Liu-wen, ZHOU Jing, LUO Xiao-hua, CHEN Rui-zhen (Shenzhen Hospital of Traditional Chinese Medicine, Guangdong Shenzhen 518033,China);Clinical Observation on the Treatment of Chronic Colonitis with Allitridum Capsule by Preserving Clysis[J];Journal of Anhui Traditional Chinese Medical College;2004-05
7 WANG Cheng ya 1, ZHOU Jian wei 2, NI li 1, et al 1 First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P R China 2 Nanjing Medical University, Applied Toxicology Institute,Nanjing 210029,P R China;Inhibitory effect of diallytrisulfide and sodium selenite on microsatellite instability in a colon cancer cell line[J];CHINESE JOURNAL OF CANCER;2000-04
8 REN Li*, ZHOU Qing hua, QIU Meng, et al Oncologic Center, the First Affiliated Hospital,West China University of Medical Sciences, Chengdu 610041,P R China;Early diagnosis of cisplatin nephrotoxicity[J];CHINESE JOURNAL OF CANCER;2000-08
9 JIANG Ying li, SONG Jin dan* Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, P.R.China;Apoptotic Induction of Xinjiang Shikonin on Human Colorectal Cancer CCL229 Cell[J];Chinese Journal of Cancer;2001-12
10 XIAO Xiao-Lan, PENG Jun, SU Qi, XIANG Shu-Lin, TANG Guo-Hua, HUANG You-Sheng, ZHOU Xiu-Tian Cancer Research Institute, Nanhua University, Hengyang, Hunan, 421001, P. R. China;Diallyl Trisulfide Induces Apoptosis of Human Gastric Cancer Cell Line MGC803 Through Caspase-3 Pathway[J];Chinese Journal of Cancer;2006-10
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 HAO Yan-mei1,2,ZHANG Lin-jie1,LI Yu-yun2(1.Department of Immunology,Anhui Medical University,Hefei 230032;2.Department of Laboratory Medicine,Bengbu Medical College,Bengbu 233030,China);Effect of growth and apoptosis on human leukaemia cells line HL-60 induced by allicin[J];Journal of Bengbu Medical College;2007-03
2 ZHENG Yan-hua(Hematology Department,Shaoxing People's Hospital,Shaoxing 132000,China);Effect of allicin on bone marrow mononuclear cells of acute mycloid leukemia[J];Strait Pharmaceutical Journal;2007-12
3 ZHU Gui-jun1,YU Zhan-biao2,HU Zhen-jie1,ZHANG Yu-xiang1(1.Department of Intensive Care Unit,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;2.Department of Intensive Care Unit,the Affiliated Hospital of Hebei University,Baoding 071000,China);EFFECT OF DIALLYL TRISULFIDE ON TNF-α AND IL-1β IN MICE WITH ACUTE LUNG INJURY INDUCED BY LIPOPOLYSACCHARIDE[J];Journal of Hebei Medical University;2007-04
4 WU Jie(School of Life Science and Chemical Engineering,Huaiyin Institute of Technology,Huai'an 223003,China);Synthesis of diallyl trisulfide and diallyl disulfide by phase transfer catalysis in the same system[J];Chemical Reagents;2009-08
5 ZHU Gui-jun1,LI Shu-jin2,YU Zhan-biao3,ZHANG Yu-xiang1,LIU Jun-feng4,HU Zhen-jie1(1.Intensive Care Unit;4.Department of Chest Surgery,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011;2.Department of Forensic Medicine,Hebei Medical University,Shijiazhuang 050011;3.Intensive Care Unit,the Affiliated Hospital of Hebei University,Baoding 071000,China);Diallyl trisulfide inhibites interleukin-1β expression induced by lipopolysaccharide through inhibiting NF-κB activation in murine lung[J];Basic & Clinical Medicine;2008-01
6 JIANG Yong-qing a,XIONG Xiang-yang b,YU Le-han c(a.2005 Grade of Medical Department,Graduate School;b.Department of Biochemistry,Medical College;c.Laboratory of Biochemistry,Medical College,Nanchang University,Nanchang 330006,China);The Inhibiting Effect of Allicin on MDA-MB-231[J];Practical Clinical Medicine;2008-05
7 ZHANG Zhi-mian1,YANG Xiao-yun1,DENG Shu-hai2,XU Wei2,SHI Cheng-yao3(1.Health Examination Center,Qilu Hospital of Shandong University;2.Institute of Pharmaceutical preparation,School of Pharmacy,Shandong University;3.Department of Pharmacy,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China);Nanoparticles of diallyl trisulfide inhibit the growth of orthotopic transplanted hepatocellular carcinoma[J];Journal of Shandong University(Health Sciences);2007-04
8 WANG Dan,ZHANG Jing-sheng,ZHAO Guang-hua(College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China);Review on mechanism of garlic greening[J];Science and Technology of Food Industry;2008-10
9 YIN Chun-hui1,HUO Shi-ran2 (1.College of Life Science, Nanjing Agricultural University, Nanjing 210095, China; 2. College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China);Antitumor Action of Allicin and Its Mehanisms[J];Food Science;2009-07
10 HE Yu-lin,GUO Xiao-qing,DU Lian-feng Zunyi Medical College Zhuhai Campus,Guangdong Zhuhai 519041,China.;The effect of garlic extract on tumor growth of S180 sarcoma-bearing mice[J];Journal of Modern Oncology;2008-06
China Proceedings of conference Full-text Database 1 Hits
1 LI Feng-ying,SHAO Shu-li,ZHANG Wei-wei;Experimental study on the therapeutic effectiveness of combined use of allicin with ADM on human hepatocarcinoma cancer QGY-7701 cells[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG KAI-HUA (Shandong Normal University);A IN VITRO CELL LINE (MGc80-3) OF A POORLY DIFFERENTIATED MUCOID ADENOCARCINOMA OF HUMAN STOMACH[J];Acta Biologiae Experimentalis Sinica;1983-03
2 Lin Chaohong~*, Fu Zhimin~*, Lin Yalun~(**), Yang Jinlong~(***) Xu Jingfang~*,Chen Qisan~*, Chen Haiming~(**) *Shanghai No. 6 People's Hospital ** Fudan Uniyersity ***Shanghai Institute of Materia Medical, Academia Sinica;THE ESTABLISHMENT OF HUMAN GASTRIC CARCINOMA CELL LINE(SGC-7901)[J];Tumor;1981-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved