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《Chinese Journal of Cancer》 2003-12
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Effect of Allitridi on Cyclin D1 and p27~(Kip1) Protein Expression in Gastric Carc inoma BGC823 Cells

Lan Hong, Lu You-Yong Beijing Laboratory of Molecular Oncology,Beijing Institute for Cancer Research,School of Oncology, Peking University, Beijing,100034, P.R.China  
BACKGROUND OBJECTIVE: Previous study showed that allitridi mar ke dly suppresses cellular proliferation, blocks cell cycle at G1 phase, and induce s cell apoptosis of human gastric cancer BGC823 cell. During the investigation o f its molecular mechanisms and target genes, the authors found that protein expr ession of cyclin D1 and p27Kip1 play an important role in an allitridi-induced G1 arrest. This study was designed to explore the effect of allitridi on the exp ression of cyclin D1 and p27Kip1 in BGC823 cells. METHODS: After total RNA and t otal protein in allitridi-treated (25 μg/ml) and allitridi-untreated BGC823 c ells were abstained, Western blot analysis was performed to determine the protei n levels of cyclin D1 and p27Kip1, and RT-PCR was performed to determine the mR NA levels of cyclin D1 and p27Kip1. RESULTS: After treated with 25 μg/ml allitr idi for 24 hours, the protein levels of cyclin D1 of BGC823 cells were downregul ated and the protein levels of p27Kip1 were upregulated, and this changes were m ore obvious after 48 hours,while their mRNA levels remained unchanged.CONCLUSION :Allitridi may influence the protein expression of cyclin D1 and p27Kip1 in BGC8 23 cells, while do not influence their mRNA transcription.
【Fund】: 国家重点基础研究发展规划项目(No.98031200);; 国家自然科学基金(No.39625016)
【CateGory Index】: R735.2
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