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《Chinese Journal of Cancer》 2003-12
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Expression of P-Glycoprotein and Lung Resistance Protein in Breast Carcinoma and Its Relationship with Prognosis

Yu Ping1, Xiao Ning-Xin2, Chen Yan-Ping3 1.Department of Mastopathy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China 2.Department of Pathology, Jiangmen Peoples Hospital, Jiangmen,Guangdong,529050, P.R.China 3.Department of Pharmacy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China  
BACKGROUND OBJECTIVE:The multidrug resistance of tumor cells i s the reason to failure of chemotherapy.The overexpression of P-glycoprotein (P- gp) and lung resistance protein (LRP) play important roles in the multidrug resi stance of breast carcinoma. The objective of this study was to investigate the e xpression of P-gp and LRP in breast carcinoma and its relationship with prognos is. METHODS:Immunohistochemical assay with the LSAB immunostai-ning technique w as used to determine protein expression of P-gp and LRP in the specimens of par affin-embedded tissues from 151 cases of breast carcinoma and 40 normal breast tissues (control). The results were evaluated on the basis of clinical pathologi cal factors and the survival time of these cases. RESULTS: The expression of P- gp were found in 62 (40.8%) of the breast carcinoma samples and in 1 (2.5%) of control samples. The difference between the two groups was statistically signif icant (χ2=21.27,P 0.01). The expression of LRP were found in 121 (80.1%) of t he breast carcinoma samples and in 22 (55.0%) of control samples. The differenc e between the two groups was statistically significant (χ2=10.62,P 0.01). The expression of P-gp were irrelative to age,tumor size,histotype,lymph nodes meta stasis,tissue grading,clinical staging,ER condition,and prognosis.The expression of LRP were found in 62 (88.6%) of 70 cases with positive lymph nodes and 59(7 2.8%) of 81 cases with negative lymph nodes. The difference between the two gro ups was statistically significant (χ2=4.891,P 0.05). The expression of P-gp w ere found in 55(45.5%) of breast carcinomas with positive immunohistochemical r eaction of LRP protein; while the expression of P-gp were found in 7(23.3%) of breast carcinomas with negative immunohistochemical reaction of LRP protein. Th e difference between the two groups was statistically significant(χ2=3.990,P 0 .05).The expression of LRP were positively correlated with the lymph nodes metas tases (r=0.197,P 0.05) and the expression of P-gp (r=0.179,P 0.05)and irrel ative to age tumor size,histotype,lymph nodes metastases,tissue grading,clinical staging,and ER condition. Univariate analysis demonstrated worse disease-free survival in the patients with positive LRP than in those with negative LRP (χ2= 6.892,P 0.01). Multivariate analysis of clinical and pathological data by Cox r egression method did not demonstrated that both expression of P-gp and LRP were independent factors affecting the survival of breast carcinoma patients. CONCLU SION: The expression of P-gp and LRP have their characteristics and dissimilari ty clinical significance in breast carcinoma tissues. The expression of LRP may correlate not only with MDR but also the lymph nodes metastases,prognosis and ex pression of P-gp in breast carcinoma tissues.
【Fund】: 广东省江门市科委科技攻关项目(No.20000906)
【CateGory Index】: R737.9
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1 PENG Zhong Min1, LUO Jing2, WANG Wei Bo3, WANG Xiao Hang1, CHEN Jing Han1, LAN Shou Min3 1.Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China 2.Department of Pathology, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China 3.Tumor Center, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China;Predictive Value of Drug Resistance related Genes Expression in Neoadjuvant Chemotherapy in Patients with Non small Cell Lung Cancer of Stage Ⅲ[J];Chinese Journal of Cancer;2004-08
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Chinese Journal Full-text Database 8 Hits
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