Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2003-12
Add to Favorite Get Latest Update

Expression of P-Glycoprotein and Lung Resistance Protein in Breast Carcinoma and Its Relationship with Prognosis

Yu Ping1, Xiao Ning-Xin2, Chen Yan-Ping3 1.Department of Mastopathy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China 2.Department of Pathology, Jiangmen Peoples Hospital, Jiangmen,Guangdong,529050, P.R.China 3.Department of Pharmacy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China  
BACKGROUND OBJECTIVE:The multidrug resistance of tumor cells i s the reason to failure of chemotherapy.The overexpression of P-glycoprotein (P- gp) and lung resistance protein (LRP) play important roles in the multidrug resi stance of breast carcinoma. The objective of this study was to investigate the e xpression of P-gp and LRP in breast carcinoma and its relationship with prognos is. METHODS:Immunohistochemical assay with the LSAB immunostai-ning technique w as used to determine protein expression of P-gp and LRP in the specimens of par affin-embedded tissues from 151 cases of breast carcinoma and 40 normal breast tissues (control). The results were evaluated on the basis of clinical pathologi cal factors and the survival time of these cases. RESULTS: The expression of P- gp were found in 62 (40.8%) of the breast carcinoma samples and in 1 (2.5%) of control samples. The difference between the two groups was statistically signif icant (χ2=21.27,P 0.01). The expression of LRP were found in 121 (80.1%) of t he breast carcinoma samples and in 22 (55.0%) of control samples. The differenc e between the two groups was statistically significant (χ2=10.62,P 0.01). The expression of P-gp were irrelative to age,tumor size,histotype,lymph nodes meta stasis,tissue grading,clinical staging,ER condition,and prognosis.The expression of LRP were found in 62 (88.6%) of 70 cases with positive lymph nodes and 59(7 2.8%) of 81 cases with negative lymph nodes. The difference between the two gro ups was statistically significant (χ2=4.891,P 0.05). The expression of P-gp w ere found in 55(45.5%) of breast carcinomas with positive immunohistochemical r eaction of LRP protein; while the expression of P-gp were found in 7(23.3%) of breast carcinomas with negative immunohistochemical reaction of LRP protein. Th e difference between the two groups was statistically significant(χ2=3.990,P 0 .05).The expression of LRP were positively correlated with the lymph nodes metas tases (r=0.197,P 0.05) and the expression of P-gp (r=0.179,P 0.05)and irrel ative to age tumor size,histotype,lymph nodes metastases,tissue grading,clinical staging,and ER condition. Univariate analysis demonstrated worse disease-free survival in the patients with positive LRP than in those with negative LRP (χ2= 6.892,P 0.01). Multivariate analysis of clinical and pathological data by Cox r egression method did not demonstrated that both expression of P-gp and LRP were independent factors affecting the survival of breast carcinoma patients. CONCLU SION: The expression of P-gp and LRP have their characteristics and dissimilari ty clinical significance in breast carcinoma tissues. The expression of LRP may correlate not only with MDR but also the lymph nodes metastases,prognosis and ex pression of P-gp in breast carcinoma tissues.
【Fund】: 广东省江门市科委科技攻关项目(No.20000906)
【CateGory Index】: R737.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 PENG Zhong Min1, LUO Jing2, WANG Wei Bo3, WANG Xiao Hang1, CHEN Jing Han1, LAN Shou Min3 1.Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China 2.Department of Pathology, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China 3.Tumor Center, Shandong Provincial Hospital, Jinan,Shandong,250021, P.R.China;Predictive Value of Drug Resistance related Genes Expression in Neoadjuvant Chemotherapy in Patients with Non small Cell Lung Cancer of Stage Ⅲ[J];Chinese Journal of Cancer;2004-08
2 WANG Xia1 WANG Peiyuan2 WU Shuhua1 et al1 Deptartment of Pathology,Binzhou Medical University,Binzhou 256603;2 Deptartment of Radiology,Binzhou Medical University;Expression and clinical significance of lung resistance protein,topoisomeraseⅡ and glutathione-S-transferase-π in non-small cell lung cancer[J];Journal of Binzhou Medical University;2009-03
3 ZHU Shao-Jun1,LI Yan-Hong2,ZHANG Wei1,ZHAO Hong-Xi2,GONG Li1,LI Yi1,HAN Xiu-Juan1,LAN Miao1 1Department of Pathology,2Department of Obstetrics and Gynecology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China;Expressions of P-glycoprotein,lung resistance-related protein,and glutathione S-transferase π in non-small cell lung cancer and their correlations with clinical prognosis[J];Journal of the Fourth Military Medical University;2008-15
4 LI Guoren, DAI Jianhua, WANG Yanqing, CHEN Guanghui, LIU Xiaofeng, MIAO Fulu, Bai Ling, CHEN Yulin. Department of Chest Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R.China;Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues[J];Chinese Journal of Lung Cancer;2002-01
5 SU Lei *, LI Zejian, DING Fang, ZHANG Heng, ZHANG Zhiyong, GE Feng, LUO Aiping, WANG Xiuqin, LIU Zhihua, WU Min. * Department of Thoracic Surgery, Peking Union Hospital, Beijing 100730, P.R.China;Effects of huTNF-α and hIL-2 gene transfection on the expression of MDR1 and LRP genes in lung cancer cell lines[J];Chinese Journal of Lung Cancer;2004-01
6 ZHANG Li, YANG Hong, DONG Dandan. Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P.R.China;Study on the relationship among multidrug resistance factor expression of lung cancer tissues and clinicopathological characteristics in patients with lung cancer[J];Chinese Journal of Lung Cancer;2006-01
7 Xiao Ningxin 1, Chen Yanping 2, Yu Ping 3 (Department of Pathology 1,The People's Hospital of Jiangmen, Jiangmen Guangdong 529050,China);RELATIONSHIP OF LRP EXPRESSION WITH C-erbB-2 AND p53 EXPRESSIONS IN BREAST CARCINOMA[J];Chinese Journal of Histochemistry and Cytochemistry;2003-01
8 LIU Zhenzhen,LIU Hui,LI Lianfang,CUI Shude Department of Breast Surgery,Henan Tumor Hospital,Zhengzhou 450008;Effect of multidrug-resistant-proteins in neoadjuvant chemotherapy in patients with breast cancer[J];Journal of Zhengzhou University(Science Medical);2005-05
9 CHEN Yan-ping1,XIAO Ning-xin2,YU Ping1. (1.Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen, Guangdong,529030 P.R. China.2. Jiangmen People's Hospital, Jiangmen, Guandong, 529050,P.R. China.);The relationchip P-glycoprotein expression with expression of C-erbB-2 and p53 in human breast carcinoma[J];Journal of Jinggangshan Medical College;2004-01
10 ZUO Yun,HUANG Jian-an,MU Chuan-yong,SHEN Dong.Department of Oncology,Zhangjiagang First People Hospital,Zhangjiagang 215600,China;The expression and significance of the multidrug resistance-related genes MDR1、MRP、LRPmRNA and their proteins P-gp、MRP、LRP in human non-small cell lung cancer tissues[J];Chinese Clinical Oncology;2006-12
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 ZHANG Li; YUAN Shi-zhen XU Ke-qiang (Division of botroenterology, Sun Yat- sen Memorial Hospital,Sun Yat-sen University of Medical Sciences, Cuangzhou, 510120, China);Expression and significance of TGF - β1 and TPR Ⅱin human pancreatic ductal adenocarcinoma[J];Chinese Journal of Cancer;1999-02
2 QIAN Xiao lei1, PENG Zhi lan1, LIU Shan ling1, WANG He1, NI Jian21.Department of Obstetrics and Gynecology,Second University Hospital of West China,Sichuan University,Chengdu 610041,P.R.China2.The Affiliated Hospital of Nantong Medical College,Nantong 226001,P.R.China;Expression of Lung Resistant-Related Protein in Ovarian Cancer and Its Clinical Significance[J];Chinese Journal of Cancer;2002-12
3 Yang Xiang-Dong1, Tang Da-Nian2, Wang Jian1, Cao De-Liang11.Centre of Molecular Biology, Nanhua University, Hengyang,Hunan,421001, P.R.China 2.Department of Surgery,Second Xiangya Hospital,Central South University, Changsha,Hunan,410011, P.R.China;Screening of the Drug Resistance-associated Gene in HepG2 Cell Line Transfected with Aldose Reductase Like Gene-1 (ARL-1)[J];Chinese Journal of Cancer;2003-12
4 ZHAO Peng1, ZHANG Ya-Zhuo2, SUN Mei-Zhen2 1. Capital University of Medical Sciences, Beijing, 100054, P. R. China 2. Beijing Neurosurgery Institute, Beijing, 100050, P. R. China;Regulatory Effect of Small Interfering RNA Targeting Multidrug Resistant Protein 1 on Chemosensitivity of Human Multiforme Glioblastoma Cell Line BT325[J];Chinese Journal of Cancer;2005-12
5 WANG Yan ming, WANG Ai min, Jiang Ren shu, LI Xian bo, ZANG Yu lin, ZHANG Guo ping, SONG Yu hong (Department of Thoracic Surgery, 252 Hospital of PLA, Baoding 071000,China);Relationship between expression of MRP gene and pathological features in esophageal carcinoma[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-03
6 XIAO Jun 1 , ZOU Fei 2 , CAI Shao-xi 3 Departments of Spinal Surgery 1 and Respiratory Medicine 3 , Nanfang Hospital, Department of Tropical Medicine 2 , First Military Medical University, Guangzhou 510515, China;Application of suppression subtractive hybridization technique in the investigation of heat adaptation mechanism[J];Journal of First Military Medical University;2003-10
7 Sun Taojiao, Zhu Youjia, Chen Jiangang, et alZhongnan Hospital, Wuhan University, Wuhan 430071, China;Expression of TGFβ1 and TGFβRⅡ in Human Oral Squamous Cell Carcinoma[J];Journal of Hubei Medical University;2004-05
8 LENG Wei-dong, WANG Da-zhang, FENG Ge, HE Jia. (Key Lab. of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China);Expression and Implication of Pgp, MRP, LRP, GST-π, TopoⅡα in Tongue Squamous Cell Carcinoma[J];West China Journal of Stomatology;2004-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved