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《Chinese Journal of Cancer》 2004-11
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Association of Functional Polymorphisms in Matrix Metalloproteinase-2 (MMP-2) and MMP-9 Genes with Risk of Gastric Cancer in A Chinese Population

ZHANG Xue Mei1, 2△, MIAO Xiao Ping2△, XIONG Ping2, YU Chun Yuan2, TAN Wen2, QU Shi Ning2, SUN Tong2, ZHOU Yi Feng2, LIN Dong Xin21.Department of Biological Sciences,North China Coal Medical College,Tangshan,Hebei,063000,P.R.China2.Department of Etiology &Carcinogenesis,Cancer Institute,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,P.R.China  
BACKGROUND OBJECTIVE: Matrix metalloproteinase 2 (MMP 2) and 9 (MMP 9) play important roles in the development of gastric cancer. This study was to investigate the association of functional polymorphisms in the MMP 2 and MMP 9 genes with risk of gastric cancer in a Chinese population.METHODS:MMP 2 -1306T/C,and MMP 9 -1562C/T polymorphisms in 228 paitents with gastric cancer, and 774 matched healthy controls were detected by polymerase chain reaction (PCR) based denaturing high performance liquid chromatography, and PCR based restriction fragment length polymorphism analysis. The adjusted odds ratios (ORs) and 95%confidence intervals (CIs) were calculated using unconditional logistic regression model. The effect modified model was used to evaluate the gene gene interaction.RESULTS: Subjects with the MMP 2 -1306CC genotype had an increased risk of developing gastric cancer compared with those with the MMP 2 -1306TT or CT genotype (adjusted OR, 1.67; 95%CI, 1.17-2.38). No significant association between MMP 9 -1562C/T polymorphism and risk of gastric cancer was observed. However, the polymorphisms in these 2 genes seem to display a gene gene interaction, with OR of 1.72 (95%CI, 1.07-2.78) for subjects carrying both MMP 2 -1306CC and MMP 9 -1562TT or CT genotypes compared with those carrying both MMP 2 -1306TT or CT and MMP 2 -1306T/C genotypes (likelihood ratio test, P=0.02). CONCLUSION: MMP 2 -1306T/C and MMP 9 -1562C/T polymorphisms may be associated with genetic susceptibility to gastric cancer.
【Fund】: 国家杰出青年科学基金(No.39825122);; 北京市科委重大项目(No.H0209-20030130)~~
【CateGory Index】: R735.2
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