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《Chinese Journal of Cancer》 2004-12
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Restorative Effect of Quercetin on Subcellular Distribution of Daunorubicin in Multidrug Resistant Leukemia Cell Lines K562/ADM and HL-60/ADM

CAI Xun1, CHEN Fang-Yuan2, HAN Jie-Ying2, GU Chun-Hong2, ZHONG Hua2, OUYANG Ren-Rong2 1.Department of Oncology, Shanghai No.6 People′s Hospital, Shanghai Jiaotong University, Shanghai,200233, P.R.China 2.Leukemia Unit,Shanghai Institute of Hematology,Renji Hospital, Shanghai Second Medical University, Shanghai,200001, P.R.China  
BACKGROUND OBJECTIVE:Quercetin,a widely distributed natural flavonoid with a variety of biological functions,can reverse multidrug resistance (MDR) in leukemia according to recent researches. This study was to investigate the mechanism of quercetin restoring subcellular distribution of daunorubicin (DNR)in multidrug resistant leukemia cell lines,K562/ADM and HL 60/ADM,and reversing their MDR. METHODS: MTT cell viability assay was used to verify the sensitization of DNR by quercetin in K562/ADM and HL 60/ADM cells,and determine the reverse concentration extent,confocal laser scanning microscope was used to observe the subcellular distribution of DNR in K562/ADM and HL 60/ADM cells,and relevant sensitive cell lines, K562/S and HL 60/S,before and after quercetin exposion. RESULTS: Compared with K562/S and HL 60/S cells,20-40 μmol/L of quercetin in vitro remarkably enhanced the sensitivity of K562/ADM and HL 60/ADM cells to DNR,restore the subcellular distribution of DNR,so as to reverse MDR. CONCLUSION: quercetin could be a candidate of effective multidrug resistance reversing agent in leukemia chemotherapy.
【Fund】: 上海市科委基金资助项目(No.994319228);; 上海市卫生局基金资助项目(No.98418)~~
【CateGory Index】: R733.7
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