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《Chinese Journal of Cancer》 2005-02
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Expression and Significance of Epidermal Growth Factor Receptor Variant Type Ⅲ in Hepatocellular Carcinoma

OU Chao1, WU Fei-xiang2, LUO Yuan3, CAO Ji1, ZHAO Yin-Nong2,YUAN Wei-Ping2, LI Yuan1, SU Jian-Jia11. Department of ExperimentPathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China2. Department of Hepatobiliary & Breast, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China3. Department of Clinical Pathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China  
BACKGROUND OBJECTIVE: Many evidences show that epidermal growth factor receptor variant type Ⅲ (EGFRvⅢ) plays an important role in initiation and progression of various cancers. But the relationship between EGFRvⅢ and hepatocellular carcinoma (HCC) is unclear. This study was to explore the expression and significance of EGFRvⅢ in human HCC tissues. METHODS: Immunohistochemical staining (IHC) was used to detect the expression of EGFRvⅢ in 55 specimens of HCC tissues and their adjacent non-cancerous liver tissues. RESULTS: Positive rate of EGFRvⅢ in HCC tissue was significantly higher than that in adjacent non-cancerous liver tissue [61.8% (34/55) vs. 38.2% (21/55), P 0.05]. Positive rate of EGFRvⅢ in HCC tissue was significantly correlated with clinical stage,portal vein tumor thrombus,presence of extrahepatic metastasis, tumor recurrence, and the diameter of tumor, but not correlated with the number of foci, serum alpha-fetoprotein (AFP) level, serum HBsAg status, tumor differentiation, and cirrhosis in adjacent liver tissue. CONCLUSION: EGFRvⅢ is over-expressed in human HCC tissues, and relates to progression and recurrence of HCC.
【Fund】: 广西留学回国人员科学基金项目(No.0009012)~~
【CateGory Index】: R735.7
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