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《Chinese Journal of Cancer》 2005-05
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Treating Renal Carcinoma with Ablation or Ablation Combined with ~(125)I Seed Implantation: a Report of Eleven Cases

QI De-Feng, WU Kai-Jun, LI Xun, ZENG Guo-Hua, CHEN Wen-ZhongMicrosurgery Center, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, 510230, P.R.China  
BACKGROUND OBJECTIVE: Recently, multi-needles radiofrequency ablation and brachyradiotherapy have been used to treat some solid tumors, such as liver cancer and prostate cancer. This study was to explore the feasibility and efficacy of radiofrequency ablation or ablation combined with 125I seed implantation on treating renal carcinoma. METHODS: From Jun. 2000 to Feb. 2004, 11 patients with a total of 13 renal carcinoma lesions were treated with ablation or ablation combined with 125I seed implantation, including 6 cases of renal carcinoma of solitary kidney, 2 cases of renal carcinoma combined with contralateral renal atrophy resulted from ureteric stone, 1 case of bilateral tumor, and 2 cases with general conditions contraindicated to surgery. Of the 13 lesions, 1 was resected by open operation, 6 were treated with multi-needles radiofrequency ablation, and 6 were treated with ablation and simultaneous 125I seed implantation around tumor margin. RESULTS: The patients were followed-up for 6-46 months (mean 27 months). One patient died of cardiac muscle infarction 4 months after operation. Of the 10 alive patients, 2 with recurrent tumors 7 months and 13 months after operation were treated with ablation again, 1 with postoperative uremia was treated with intermittent peritoneal dialysis, the rest 7 had normal renal function. CONCLUSION: Multi-needles radiofrequency ablation or ablation combined with 125I seed implantation would be an option in the treatment for patients with renal carcinoma of solitary kidney or bilateral kidney lesions, or for patients can't suffer from surgery.
【Fund】: 广东省科委基金项目(No.99B06701G);; 广州市科委基金项目(No.2000-Z-027-01-1)~~
【CateGory Index】: R737.11
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