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《Chinese Journal of Cancer》 2005-10
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Prognostic Analysis of Stage Ⅲ-Ⅳ Non-small Cell Lung Cancer Patients Treated by Traditional Chinese Medicine

ZHOU Dai-Han1, LIN Li-Zhu1, ZHOU Yi-Qiang2, LUO Rong-Cheng3, LIU Kui-Feng4, JIA Ying-Jie5, CHEN Ji-Yue6, NIU Xi-Wei2, SU Bi-Ru7, LU Jiang8, WANG Shu-Tang1 1. Cancer Center, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510405, P. R. China 2. Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, 450002, P. R. China 3 Cancer Center, Southern Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China 4. Department of Oncology, The Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, P. R. China 5. Department of Oncology, The First Affiliated Hospital, Tianjin College of Traditional Chinese Medicine, Tianjin, 300193, P. R. China 6. Department of Oncology, The 421 Naval Hospital, Guangzhou, Guangdong, 510318, P. R. China 7. The First Chinese Medicine Factory of Guangzhou, Guangzhou, Guangdong, 510130, P. R. China 8. Jilin Yatai Pharmaceutical Company, LTD., Changchun, Jilin, 130031, P. R. China  
BACKGROUND OBJECTIVE: Chemotherapy is a treatment for stage Ⅲ-Ⅳ non-small cell lung cancer (NSCLC), but the efficacy is not ideal. Traditional Chinese medicine (TCM) has certain effect on NSCLC. This study was to investigate various factors that affect the prognosis of advanced NSCLC, and evaluate the role of TCM in enlonging survival time of patients with stage Ⅲ-Ⅳ NSCLC. METHODS: The NSCLC patients who meet the inclusive criteria were randomized into TCM group, combination (TCM plus NP regimen) group, and chemotherapy group, and received relevant treatments. The median survival time (MST) was calculated by Kaplan-Meier method. The prognosis of the patients was analyzed by COX regression method. RESULTS: A total of 294 stage Ⅲ-Ⅳ NSCLC patients were enrolled, of which 99 were in TCM group, 103 in combination group, 92 in chemotherapy group. The MST were 292 days in TCM group, 355 days in combination group, and 236 days in chemotherapy group; the cumulative survival rates were 45.38%, 48.86%, and 42.17%, respectively (P0.05). Cox regression analysis indicated that therapy, gender, disease course, erythrocyte sedimentation, KPS score, tumor size, and patient's weight were independent prognostic factors of stage Ⅲ-Ⅳ NSCLC. CONCLUSION: Compare with chemotherapy alone, TCM combined with chemotherapy may prolong the survival time of stage Ⅲ-Ⅳ NSCLC patients.
【Fund】: 国家科技部“十五”重点攻关课题(No.2001BA701A15b)~~
【CateGory Index】: R273
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【References】
Chinese Journal Full-text Database 4 Hits
1 LI Ying-li SHANG Ning GU Xiao-yan et al Respiratory Department,the 454 Hospital of PLA of China(Nanjing 210002);Comparative Study of Treating Late Lung Cancer with Aidi Injection and Huachansu Injection[J];Journal of Hebei Traditional Chinese Medicine and Pharmacology;2008-02
2 GE Ming,WANG Yi-gang,ZHEN Yan-jun,SUN Cheng-qi(Department Of Traditional Chinese Medicine,The Affiliated Drum Tower Hospital Of Nanjing University Medical School,Jiangsu,Nanjing,210008);Comparative Study Of Advanced Lung Cancer with Huachansu Injection And Aidi Injection[J];Journal of Clinical Medicine in Practice;2007-01
3 ZHOU Jing-xu LIN Li-zhu Department of Oncology,The First Clinical Medical College,Guangzhou TCM University,Guangzhou (510407);Integrative Medical Strategy for Treatment of Senile Lung Cancer[J];Chinese Journal of Integrated Traditional and Western Medicine;2008-12
4 YAO Quan-bao1,WANG Li-xin2,NI Wei3,SHEN Yi-li1,ZHU Yan1,ZHENG Xin1(1.Shanghai First People's Hospital Branch Affiliated to Shanghai Jiaotong University,Shanghai 200081,China;2.Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China;3.Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China);Clinical Observation of "YangYin RuanJian" on the Quality of Life in Non-Small Cell Lung Cancer[J];Chinese Archives of Traditional Chinese Medicine;2010-01
China Proceedings of conference Full-text Database 2 Hits
1 XU Zhen-Ye CAI Xiao-Yue Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Consideration on Some Strategies and Problems of the Malignancy Treatment by Traditional Chinese Medicine[A];[C];2008
2 ;Clinical policies for lung cancer for elder patients[A];[C];2007
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Translators: Yang Xuening, Liao Riqiang, Wu Yilong Lung Cancer Research Center,Department of Cardiothoraclc Surgery,The Thid Affilated Hospital,Sun Yat-sen University,Guangdong Scientific Research Center of Evidence-Based Medicine, Guangzhou 510630, P. R China;NCCN Non-Small Cell Lung Cancer Practice Guidelines[J];The Journal of Evidence-based Medicine;2002-04
2 Chen Zhifeng, Li Chengzhu, Liu Shaoxiang et al. Institute of Oncology, Shijiazhuang, Hebei 050011;Meta Analysis on Primary Non- small Cell Lung Carcinoma (NSCL) Treated by TCM in China[J];Journal of Traditional Chinese Medicine;1999-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Yan, WANG Sen ming, ZHANG JianDepartment of Oncology,Zhujiang Hospital,Guangzhou 510282,P.R.China;Combination Chemotherapy with Taxol and Cisplatin for 57 Patientswith Non-Small Cell Lung Cancer by Intraarteryand Intravenous Infusion[J];Chinese Journal of Cancer;2002-12
2 Li Jinhan Oncology Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The treatment for non-small cell lung cancer:Look back in 40 years and recent advance[J];Oncology Progress;2006-06
3 Li Jinhan Dept.of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The treatment of non-small cell lung cancer with integrated traditional Chinese medicine and Western medicine:Improving survival[J];Oncology Progress;2006-06
4 WANG Ji dong,ZHANG Yin xiu,XU Yang,ZHOU Ping (Department of Oncology,Anqing Hospital of PLA Navy,Anhui 246003,China);Vinorelbine plus cisplatin therapy for treatment of advanced non-small cell lung cancer[J];Journal of Bengbu Medical College;2004-01
5 TAO Zhi-rong(Department of Hematology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Application and nursing of TOP transfusion pump in the VAD projet for treating multiple myeloma[J];Journal of Bengbu Medical College;2007-05
6 Liu Zhe, Zhu Yunzhong, Xu Liyan, et al(Department of Medical Oncology and Radiotherapy, Beijing Thoracic Tumor and Tuberculosis Hospital, Beijing 101149);Randomized study of concurrent versus sequential hyperfractionated radiotherapy in combination with cisplatin and etoposide for limited-stage small cell lung cancer[J];Beijing Medical Journal;2005-11
7 Qun-Ying Yang Guang-Chuan Xu Li-Kun Chen Department of medical oncology,,Cancer Cencer,Sun Yat-sen University,Guanzhou 510060,P.R.China;Progress in the Study of Penetration into Blood-brain Barrier of New Anti-lung Cancer Drugs[J];Chinese Journal of Neuro-Oncology;2004-03
8 Lu Wei-kun (Qinzhou City Hospital of Traditional Chinese Medieine,Guangxi,Qinzhou 535000,China);The Clinical Value of CT-guided Percutaneous Comprehensive Targeting Treatment in the Advanced Hepatocellular Carcinoma[J];Chinese Journal of Medicinal Guide;2008-02
9 ZHU Yunzhong , SHI Heling, QIAN Hao, HUANG Wenxia, HONG Zhuan, ZHANG Yiping, XU Nong, ZHANG Li, LIU Donggeng, DONG Zhongsheng, LI Shufen, ZHANG Lijian, ZHENG Wen. Beijing Thoracic Tumor Research Institute, Beijing 101149, P.R.China;The phase Ⅱ clinical trial of Seratia Marcescens Anticancer Vaccine (S311)for malignant pleural effusions[J];Chinese Journal of Lung Cancer;2001-04
10 WANG Kun , SUN Yu'e, WANG Tao. Department of Thoracic Surgery, General Hospital of Beijing Unit, PLA, Beijing 100700, P.R.China;The prognostic significance of GLUT1 expression in stage Ⅰ and Ⅱ NSCLC[J];Chinese Journal of Lung Cancer;2002-06
China Proceedings of conference Full-text Database 3 Hits
1 Oncology Department, First Military Medical University Affiliated Southern Hospital, Guangzhou, 510515 Li Jianhan;Progress in Treating the Non-Small Cell Lung Cancer with Integrated Traditional and Western Medicine[A];[C];2004
2 XU Zhen-Ye CAI Xiao-Yue Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Consideration on Some Strategies and Problems of the Malignancy Treatment by Traditional Chinese Medicine[A];[C];2008
3 ;A clinical study on treating NSCLC by therapy of Yi-qi Hua-tan[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WAN Sheng Yun,LIU Yi, ZHANG Jun Shun (Dept of Surgery,Afficiated Hospital,Anhui Medical Univesty,Hefei 230022);Quantitation of local 5-Fu concent in the patients with rectal cancer performed 5-Fu SRI local chemotherapy[J];Anhui Medical and Pharmaceutical Journal;2003-04
2 Chen Xiaoyin,Shen Zhuoqun (Departmant of TCM,Medical College of Jin'an University,Guangzhou 510632,China);EFFECTS OF QIONGYUGAO ON THE EXPRESSION OF NM23 AND PCNA OF EXPERIMENTAL LUNG CANCER MICE TREATED BY CHEMOTHERAPY[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
3 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
4 Shi Xiaochun Zhang XiaotongDepartment of Pulmonary Medicine,PUMC Hospital,CAMS & PUMC,Beijing 100730,China;Gefitinib in elderly and unfit patients affected non-small-cell lung cancer[J];Oncology Progress;2005-06
5 Zhang Lihong,Ge Yi,Wang Min,et al (Department of Otolaryngology,People’s Hospital,Peking University,Beijing 100044);Significance of endostatin and VEGF expression in laryngeal carcinoma and vocal polyps[J];Beijing Medical Journal;2003-05
6 XIAO Yan, WEI Ping kang, XU Ling, et al Changzheng Hospital, The Second Military Medical College (Shanghai,200003,China);Influence on Traditional Chinese Medicine of Dispelling Phlegm to Eliminating Stagnation to Expression of MMP_2 in MKN-45 Gastric Carcinoma Tissue on Nude Mouse[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2002-04
7 LI De zhi,CHEN Zheng tang (Cancer Center of PLA,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China);Clinical analysis of fractionated sterotactic radiotherapy for aged patients with lung cancer[J];Chongqing Medical Journal;2004-07
8 CAI Hong-bing1, DAI Fang-guo2, MIN Qing-fen3, SHI Min1, MIAO Jing-xia1, LUO Rong-cheng1Oncology Center, Nanfang Hospital1; Teaching Affairs Administration2; Department of Respiration, Nanfang Hospital3, First Military Medical University, Guangzhou 510515, China;Clinical study of the effects of radiotherapy in combination with traditional Chinese medicine on non-small cell lung cancer[J];Journal of First Military Medical University;2002-12
9 WTBX ZHOU Qinghua , QIU Meng, HOU Mei, REN Li, LI Lu, YI Cheng, YANG Yuqiong, LIU Lunxu, LI Zhiping, XU Yong, LUO Deyun, WANG Q ixia, ZHANG Lijian, LIN Jiangtao, SHI Jing. Cancer Center, The First University Hospital, West China University;A multicenter randomized phase trial of domestic prod uct of rhG CSF(Rui Xue Xin) in preventing leukopenia caused by chemotherapy in patients with lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-03
10 WANG Siyu, WU Yilong, OU Wei, YANG Xuening, Y U Hui. Lung Cancer Research Center, Sun Yet sen University of Medical Sciences , Guangzhou, Guangdong 510060, P.R.China;Survival and prognosis after pneumonectomy for non small cell lung canc er (NSCLC) in the elderly[J];CHINESE JOURNAL OF LUNG CANCER;2000-03
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