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《Chinese Journal of Cancer》 2005-10
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Prognostic Analysis of Stage Ⅲ-Ⅳ Non-small Cell Lung Cancer Patients Treated by Traditional Chinese Medicine

ZHOU Dai-Han1, LIN Li-Zhu1, ZHOU Yi-Qiang2, LUO Rong-Cheng3, LIU Kui-Feng4, JIA Ying-Jie5, CHEN Ji-Yue6, NIU Xi-Wei2, SU Bi-Ru7, LU Jiang8, WANG Shu-Tang1 1. Cancer Center, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510405, P. R. China 2. Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, 450002, P. R. China 3 Cancer Center, Southern Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China 4. Department of Oncology, The Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, P. R. China 5. Department of Oncology, The First Affiliated Hospital, Tianjin College of Traditional Chinese Medicine, Tianjin, 300193, P. R. China 6. Department of Oncology, The 421 Naval Hospital, Guangzhou, Guangdong, 510318, P. R. China 7. The First Chinese Medicine Factory of Guangzhou, Guangzhou, Guangdong, 510130, P. R. China 8. Jilin Yatai Pharmaceutical Company, LTD., Changchun, Jilin, 130031, P. R. China  
BACKGROUND OBJECTIVE: Chemotherapy is a treatment for stage Ⅲ-Ⅳ non-small cell lung cancer (NSCLC), but the efficacy is not ideal. Traditional Chinese medicine (TCM) has certain effect on NSCLC. This study was to investigate various factors that affect the prognosis of advanced NSCLC, and evaluate the role of TCM in enlonging survival time of patients with stage Ⅲ-Ⅳ NSCLC. METHODS: The NSCLC patients who meet the inclusive criteria were randomized into TCM group, combination (TCM plus NP regimen) group, and chemotherapy group, and received relevant treatments. The median survival time (MST) was calculated by Kaplan-Meier method. The prognosis of the patients was analyzed by COX regression method. RESULTS: A total of 294 stage Ⅲ-Ⅳ NSCLC patients were enrolled, of which 99 were in TCM group, 103 in combination group, 92 in chemotherapy group. The MST were 292 days in TCM group, 355 days in combination group, and 236 days in chemotherapy group; the cumulative survival rates were 45.38%, 48.86%, and 42.17%, respectively (P0.05). Cox regression analysis indicated that therapy, gender, disease course, erythrocyte sedimentation, KPS score, tumor size, and patient's weight were independent prognostic factors of stage Ⅲ-Ⅳ NSCLC. CONCLUSION: Compare with chemotherapy alone, TCM combined with chemotherapy may prolong the survival time of stage Ⅲ-Ⅳ NSCLC patients.
【Fund】: 国家科技部“十五”重点攻关课题(No.2001BA701A15b)~~
【CateGory Index】: R273
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