Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2006-02
Add to Favorite Get Latest Update

Expression and Significance of GST-Pi and HIF-1αin Bladder Carcinoma

DENG Jian-Hua, BAI Jin-Liang, MA Peng-Cheng, ZHANG Shi-Sheng, WAN Jiang-Hou Department of Urology, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu, 730000, P. R. China  
BACKGROUND OBJECTIVE: Multidrug resistance plays an important role in chemotherapy failure of bladder cancer, but its mechanism is unclear. Hypoxia in tumors is generally associated with chemoresistance. However, the correlation of nuclear transcription factor hypoxia-inducible factor-1 (HIF-1) to multidrug resistance transporter glutathione-S-transferase- Pi (GST-Pi) has not been investigated. This study was to explore the expression and significance of GST-Pi and its correlation to HIF-1α in bladder carcinoma by tissue microarray. METHODS: A tissue microarray containing 119 cases of bladder carcinoma and 6 cases of normal bladder tissue was built up. The expression of GST-Pi and HIF-1αwas detected by SABC immunohistochemistry. RESULTS: In the 119 cases of bladder carcinoma, the positive rate of HIF-1αwas 57.9%, the positive rate of GST- Pi was 67.2%. The positive rate of HIF-1αin G3 grade bladder carcinoma was 64.6%. Their expression was closely related to pathologic grade, clinical stage, and postoperative relapse after adjuvant chemotherapy (P0.01). HIF-1αexpression was positively related to GST-Pi expression (P 0.01). CONCLUSIONS: Overexpression of HIF-1αmay be related to hypoxia. Co- expression of HIF-1αand GST-Pi is a object index for judging differentiation and chemoresistance of bladder cancer.
【CateGory Index】: R737.14
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 LI Li,LIANG Gang.(Department of Pharmacology,Guangxi Medical University,Nanning 530021,China);Progress about HIF-1 in Multi-drug Resistance of Solid Tumors[J];Medical Recapitulate;2007-13
Chinese Journal Full-text Database 10 Hits
1 LI Yan-bo1,SUN Jing2,LI Jie2(1.Shandong Provincial Hospital,Shandong University,Shandong Ji'nan 250021,China;2.Shandong University of Traditional Chinese Medicine,Shandong Ji'nan 250355,China);Antiangiogenesis Effect of Reinforcing qi and Nourishing yin Recipe and Its Effects on Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Tumor Cells[J];Journal of Anhui Traditional Chinese Medical College;2010-02
2 WANG Yan ming 1, CHEN Zhi xia 1, WANG Ai min 2, et al 1 Department of Thoracic Surgery, 252 Hospital of PLA, Baoding 071000, P R China 2 Central Laboratory, 252 Hospital of PLA, Baoding 071000,P R China;Clinical study of mdr-1 and mrp gene expression in patients with esophagus cancer[J];CHINESE JOURNAL OF CANCER;2000-04
3 LI Meng da* , LI Yan fang, LI Jun dong, LIU Fu yuan, LIU Ji hong. Department of Gynecologic Oncology,Cancer Center,Sun Yat sen University of Medical Sciences, Guangzhou 510060, P.R.China;The clinical significance of in vitro chemosensitivity test for ovarian cancer[J];Chinese Journal of Cancer;2000-12
4 FAN Li-fang * ,DIAO Lu-ming,CHEN De-ji,LIU Ming-qiu,ZHU Li-qin,LI Hong-gang,TANG Zhi-jiao,XIA Dong ,LIU Xuan,CH EN Hong-lei Department of Pathology,Medical Co llege,Wuhan University,Wuhan 430071,P.R.China;Expression of HIF-1αand Its Relationship to Apoptosis and Proliferation in Lung Cancer[J];Chinese Journal of Cancer;2002-03
5 Yu Dong Qing, Yi Yong Fen Department of Pathology, Chongqing Medical University, Chongqing, 400016, P.R.China;Expression and Significance of MRP,GSTπ,TopoⅡα,and LRP in Gastric Carcinoma[J];Chinese Journal of Cancer;2003-05
6 Jiang Cong-Qing, Liu Zhi-Su, Qian Qun, He Yue-Ming, Yuan Yu-Feng, Ai Zhong-Li Third Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, P. R. China;Relationship of Hypoxia-lnducible Factor 1 Alpha (HIF-1α) Gene Expression with Vascular Endothelial Growth Factor (VEGF) and Microvessel Density (MVD) in Human Colorectal Adenoma and Adenocarcinoma[J];Chinese Journal of Cancer;2003-11
7 HUANG Lei1, AO Qi-Lin2, LI Fang1, XING Hui1, LU Yun-Ping1, MA Ding1 1. Molecular Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China 2. Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China <;Impact of Hypoxia on Taxol-induced Apoptosis in Human Ovarian Cancer Cell Line A2780 and Its Mechanism[J];Chinese Journal of Cancer;2005-04
8 WU Qiang, YANG Shu-Hua, WANG Rui-Ying, YE Shu-Nan, XIA Tian, MA De-ZhangDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P.R.China;Effect of Silencing HIF-1α by RNA Interference on Expression of Vascular Endothelial Growth Factor in Osteosarcoma Cell Line SaOS-2 under Hypoxia[J];Chinese Journal of Cancer;2005-05
9 CAO Qi-zhen1, LIN Shu-qian2, WANG Sai-zhen2, LIN Zhi-bin1,2(1.Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083,China;2.Fuzhou Institute of GreenValley Bio-Pharm Technology);Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro[J];Journal of Peking University(Health Sciences);2007-06
10 DUAN Hong~1, ZHANG Jun-wen~2 (~1Department of Pathophysiology, ~2Department of Gastroenterology, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China);Induction of apoptosis and influence of HIF-1α expression on esophageal carcinoma cell ECa109 by soybean isoflavone during hypoxia[J];Acta Academiae Medicinae Militaris Tertiae;2005-19
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Yang LV,Peng ZHANG Department of Thoracic Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China;Advances of HIF-1α and Its Role in Lung Cancer[J];Chinese Journal of Lung Cancer;2009-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved