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《Chinese Journal of Cancer》 2006-02
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Expression and Significance of GST-Pi and HIF-1αin Bladder Carcinoma

DENG Jian-Hua, BAI Jin-Liang, MA Peng-Cheng, ZHANG Shi-Sheng, WAN Jiang-Hou Department of Urology, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu, 730000, P. R. China  
BACKGROUND OBJECTIVE: Multidrug resistance plays an important role in chemotherapy failure of bladder cancer, but its mechanism is unclear. Hypoxia in tumors is generally associated with chemoresistance. However, the correlation of nuclear transcription factor hypoxia-inducible factor-1 (HIF-1) to multidrug resistance transporter glutathione-S-transferase- Pi (GST-Pi) has not been investigated. This study was to explore the expression and significance of GST-Pi and its correlation to HIF-1α in bladder carcinoma by tissue microarray. METHODS: A tissue microarray containing 119 cases of bladder carcinoma and 6 cases of normal bladder tissue was built up. The expression of GST-Pi and HIF-1αwas detected by SABC immunohistochemistry. RESULTS: In the 119 cases of bladder carcinoma, the positive rate of HIF-1αwas 57.9%, the positive rate of GST- Pi was 67.2%. The positive rate of HIF-1αin G3 grade bladder carcinoma was 64.6%. Their expression was closely related to pathologic grade, clinical stage, and postoperative relapse after adjuvant chemotherapy (P0.01). HIF-1αexpression was positively related to GST-Pi expression (P 0.01). CONCLUSIONS: Overexpression of HIF-1αmay be related to hypoxia. Co- expression of HIF-1αand GST-Pi is a object index for judging differentiation and chemoresistance of bladder cancer.
【CateGory Index】: R737.14
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【Co-references】
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1 LI Yan-bo1,SUN Jing2,LI Jie2(1.Shandong Provincial Hospital,Shandong University,Shandong Ji'nan 250021,China;2.Shandong University of Traditional Chinese Medicine,Shandong Ji'nan 250355,China);Antiangiogenesis Effect of Reinforcing qi and Nourishing yin Recipe and Its Effects on Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Tumor Cells[J];Journal of Anhui Traditional Chinese Medical College;2010-02
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【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Yang LV,Peng ZHANG Department of Thoracic Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China;Advances of HIF-1α and Its Role in Lung Cancer[J];Chinese Journal of Lung Cancer;2009-02
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