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《Chinese Journal of Cancer》 2006-04
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Effects of Suramin in Combination with Cisplatin on Growth and Metastasis of Lung Adenocarcinoma Xenografts in Mice

ZHANG Ping, HE Jian-Bin, OU Li-Wen, WANG Xiao-HuaDepartment of Respiratory Medicine, The First Affiliated Hospital, Nanhua University, Hengyang, Hunan, 421001,P. R. China  
BACKGROUND OBJECTIVE: Recent study found angiogenesis plays some important roles in tumor growth and metastasis. This study was to explore the inhibitory effect of angiogenesis inhibitor Suramin in combination with cisplatin (DDP) on the growth and lung metastasis of lung adenocarcinoma LA795 cell xenografts in mice. METHODS: Highly metastatic LA795 cells were inoculated into the mammary fatty pad of 32 T739 mice to establish lung adenocarcinoma models. Four days after inoculation, the mice were randomized into 4 groups: the mice in control group received intraperitoneal injection of 0.2 ml normal saline everyday; the mice in DDP group received injection of DDP [2 mg·(kg·day)-1] at the 4th, 11th, and 18th days; the mice in Suramin group received injection of Suramin [10 mg·(kg·day)-1] everyday; the mice in combination group received injection of DDP [2 mg·(kg·day)-1] at the 4th, 11th, and 18th days, and Suramin [10 mg·(kg·day)-1] everyday. All mice were killed 24 days later. Lung and subcutaneous tumors were examined histologically. The metastatic tumor foci on lung surface were observed, lung weight was measured, the occurrence rate of lung metastasis and the inhibitory rate of metastatic foci were calculated, subcutaneous tumor microvessel density (MVD), vascular endothelial growth factor (VEGF), and nuclear factor-kappaB( NF-κB) were determined by immunohistochemistry, and tumor cell apoptosis was measured by TUNEL method. RESULTS: In DDP, Suramin, and combination groups, tumor growth was suppressed significantly, with growth inhibitory rates of 23.0%, 34.4%, and 56.3%, respectively (P0.05). Necrosis and decrease of tumor vessels were observed in Suramin and combination groups. The expression of NF-κB was significantly lower and tumor cell apoptosis index was significantly higher in DDP, Suramin, and combination groups than in control group (P0.01). The metastatic foci on lung surface were less in Suramin and combination groups than in DDP and control groups. The expression of MVD and VEGF in subcutaneous tumors and the occurrence rate of lung metastasis were also obviously lower in Suramin and combination groups. CONCLUSION: Suramin has synergetic inhibitory effect with DDP on growth and metastasis of lung adencarcinoma LA795 cell xenografts in mice through inhibiting angiogenesis and inducing cell apoptosis.
【Fund】: 湖南省卫生厅科研基金项目(No.2005033)~~
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 5 Hits
1 OU Li-wen,LUO Yun-hai.The Department of Respiratory,the affiliated hospital of XiangNan University.Huo Jianbing,Zhang Ping,The teaching and research unit of clinic nurse,The nurse college of NanHua University;The effect of suramin in combination with adriamycin on HIF-1α and VEGF expressions in mice transplanted with lung adenocarcinoma[J];Journal of Chinese Physician;2006-11
2 Huang Hongsi,Huang Weitong,Wei Pengya,et al.(Department of microbiology and immunology,Youjiang medical college for nationalities ,Bose 533000,Guangxi China);EXPERIMENTAL RESEARCH ON ASTRAGALUS POLYSACCHARIDES WITH CISPLATIN IN TREATING H22 LIVER CANCER[J];Journal of Guangxi Medical University;2009-01
3 ZHANG Jun,CAO Pei-Guo,FU Hui-Qun,et al.(The Third Xiangya Hospital,Central South University Changsha,Hunan 410013,China);Experimental Research on TMP Combination with DDP in Treating Lewis Lung Carcinoma[J];Journal of Clinical Research;2006-08
4 HUANG Hong-si,HUANG Wei-tong,WEI Peng-ya,HUANG Yan-qiang(Youjiang Medical College for Nationalities,Baise 533000,China);Experimental Research on Astragalus Polysaccharides Combined with Cisplatin in Treating H22 Liver Cancer[J];Lishizhen Medicine and Materia Medica Research;2008-11
5 OU Liwen1,LUO Yunhai1,ZONG Xiaojian2 (1. Department of Respiratory,2. Department of Gynecologic,the Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,P.R.China);Study of Suramin in combination with Adriamycin and its efficacy on the bFGF and NF-КBp65 in the transplantation of Lung-adenocarcinoma of mice[J];China Journal of Modern Medicine;2009-12
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Yang Li Hua1, Wang Kai Feng2, Zhou Yi Ping2, Li Ma Lin2 1.Department of Obstetric and Gynecology,Second Affiliated Hospital,Kunming Medical College, Kunming,Yunnan,650101, P.R.China 2.Yunnan Pharmacological Laboratory of Natural Product, Kunming,Yunnan,650101, P.R.China;Role and Mechanism of Nuclear Factor κB in Angiogenesis of Human Ovarian Carcinoma[J];Chinese Journal of Cancer;2004-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 XIA Ke-Dong1, CHEN Xiang-Min2, LIN Qiao-Ai1, DONG Hai-Yan1, CHEN Shao1, ZHANG Li-Fang1 1. Department of Microbiology and Immunology, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, P. R. China 2. Center Laboratory of Biology, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, P. R. China;Correlation of Expression of Nuclear Factor κB, Inhibitor Protein κB, and Bcl-2 in Cervical Cancer to Human Papillomavirus Infection[J];Chinese Journal of Cancer;2005-11
2 HE Jian-Bin1, YI Gao-Zhong1, YANG Kai1, XIANG Zhi1, XIE Mao-Feng1, ZHANG Ping21. Department of Respiratory Diseases, The First People’s Hospital of Huaihua City, Huaihua, Hunan, 418000, P. R. China 2. Department of Respiratory Diseases, The First Affliliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China;Inhibitory Effects of Suramin on Growth of Transplanted Lung Adencarcinoma in Mice and Its Mechanisms[J];Chinese Journal of Cancer;2008-04
3 WANG Kun1,2,CUI Man-hua1,HE Kai(1.Department of Obstetrics and Gynecology,Second Hospital,Jilin University,Changchun 130041,China;2.Maternal and Child Health Hospital of Shenzhen,Southern Medical University, Shenzhen 518028,China);Effect of antioxidant PDTC on expression of IL-8 in human ovarian caner cell line SKOV3 in acidic environment[J];Journal of Jilin University(Medicine Edition);2007-04
4 FU Hui-qun1, TAO Guang-shi2, ZHANG Juan1, LI Zheng3(1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013;2.Department of Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011;3.Cancer Research Institute, Central South University, Changsha 410078, China);Inhibitory effect of quercetin on cervix cancer in mice[J];Journal of Central South University(Medical Sciences);2007-05
5 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
6 HE Zhi-gang (Department of Medical Oncology,Liangang Hospital,Hunan 417009,China);The expression and significance of NFκBmRNA in ovarian cancer[J];Modern Medicine & Health;2008-06
7 HE Jian-bing1,XIANG Zhi1,YANG Kai2,ZHANG Ping2 (1.Department of Respiration,the First People′s Hospital of Huaihua,Huaihua,Hunan 418000,P.R.China; 2.Department of Respiration,the First Affliliated Hospital of Nanhua University,Hengyang,Hunan 421001,P.R.China);Inhibitory effects of suramin on lung adencarcinoma and expression of bFGF in mice[J];China Journal of Modern Medicine;2008-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Xu Du Juan, Chen Ming Zhu (Institute of Clinical Pharmacology , Anhui Medical University ,Hefei 230032);Effect of astragalus polysaccharide on immunologic function in mice[J];Anhui Medical and Pharmaceutical Journal;2003-06
2 WANG Tao1*, JIN Ge2, WANG Shu mei1, et al 1 Department of Respiratory Medicine, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, P R China 2 The School of Basic Medical Sciences, Henan Medical University, Zhengzhou 450052,;Induced differentiation of human lung adenocarcinoma cells by cinnamic acid[J];CHINESE JOURNAL OF CANCER;2000-08
3 LU Zhi-Qiang1, LI Hai-Gang2, XIE De-Rong3, ZHANG Hui-Zhong4, SHEN Xi-Ming2, ZENG Yun-Jie2, ZENG Hong21. Department of Respiratory Medicine, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P.R.China2. Department of Pathology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P. R. China3. Department of Oncology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P.R.China4. Department of Cardiothoracic Surgery, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P.R.China;Expression and Clinical Significance of Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor Receptor 3 in Non-small Cell Lung Carcinoma[J];Chinese Journal of Cancer;2005-09
4 Wang Shulan, Wu Shengdong,Li Shulian, Xiao Hong, Dong Chongtian, Cui Li(Dept. of Histol. and Embryol., College of Basic Med. Sci.; Dept. of Combination of Traditional Chinese and Western Med.);EXPERIMENTAL STUDY ON THE EFFECT OF FRUCTUS LYCII AND 7 OTHER CHINESE DRUGS ON CELLS CULTURED IN VITRO AND MACROPHAGES OF THE ABDOMINAL CAVITY IN MICE[J];;1990-04
5 OU Li-wen,LUO Yun-hai.The Department of Respiratory,the affiliated hospital of XiangNan University.Huo Jianbing,Zhang Ping,The teaching and research unit of clinic nurse,The nurse college of NanHua University;The effect of suramin in combination with adriamycin on HIF-1α and VEGF expressions in mice transplanted with lung adenocarcinoma[J];Journal of Chinese Physician;2006-11
6 Shi Guangxia et al(Department of Pathophysiology,Dalian Medical University);Experimental investigation on antitumor effect of β-elemene I In vitro cytotoxic effect of β-elemene on L615 leukemic cells[J];;1994-02
7 SUN Yan Ni, LI Qiang, LIU Zhong Ling, BAI Chong, HAN Yi Ping, HUANG Yi, ZHAO Li Jun, YAO Xiao Peng Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanhhai 200433, China;Relationship between VEGF expression, tumors growth and wtp53 gene transfection in human lung adenocarcinoma cell line A549[J];Journal of The Fourth Military Medical University;2004-15
8 ZHAO Zhongsheng, ZHANG Mei, RU Guoqing. Department of pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014,P.R.China;Expression of MMP-2 and MMP-9 in non small cell lung cancer and their prognostic value[J];CHINESE JOURNAL OF LUNG CANCER;2000-02
9 WANG Xinyun, YANG Juhong, MA Ying, ZHENG Haiyan, CHENG Bo, ZHENG Hongwei, ZHU Congzhong. Department of Pathology, Tianjin Medical University, Tianjin 300070, P.R.China;Expression and significance of matrix metalloproteinases and their tissue inhibitors in the infiltration and metastasis of lung cancer[J];Chinese Journal of Lung Cancer;2003-04
10 ZHOU Qinghua, WANG Yanping, CHE Guowei, ZHU Wen, CHEN Xiaohe, CHEN Xiaofeng, SUN Zhilin. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Establishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human lung large cell carcinoma cell line (WCQH-9801)[J];Chinese Journal of Lung Cancer;2003-06
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 Xue Song,Zhong Meizuo~*,Liu Wei,Li Jianhuang,Huang Jin (Department of Oncology,Xiang Ya Hospital of Central South University,Changsha,Hunan, China,410008);The experimental study for HFD's mechanism to inhibit Lewis lung cancer in mice[J];Anti-tumor Pharmacy;2011-01
2 Yang Jian-bo, Li Xiao-sheng Department of Gastroenterology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;Effect of tetramethylpyrazine on transforming growth factor beta 1-induced connective tissue growth factor expression:Role of p38 mitogen-activated protein kinase pathways in hepatic stellate cells[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-37
3 YANG Yang XU Xiao-yu;Development of therapy of the efficient element of Chinese medicine on Lewis lung cancer[J];Chinese Journal of Lung Diseases(Electronic Edition);2010-06
4 OU Liwen1,LUO Yunhai1,ZONG Xiaojian2 (1. Department of Respiratory,2. Department of Gynecologic,the Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,P.R.China);Study of Suramin in combination with Adriamycin and its efficacy on the bFGF and NF-КBp65 in the transplantation of Lung-adenocarcinoma of mice[J];China Journal of Modern Medicine;2009-12
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Guangyu *, ZHAO Min, XU Mingtang, YANG Yonghui,WANG Mengshan,YANG Chunzheng *State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China;Correlation of angiogenesis with expression of vascular endothelial growth factor and its receptors in lung carcinoma[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2002-02
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