Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2006-09
Add to Favorite Get Latest Update

Correlations of S100A4 Protein Expression to Invasion and Metastasis of Non-small Cell Lung Cancer

CHEN Xiang-Li1, ZHANG Wang-Gang1, CHEN Xiao-Yan2, SUN Zhong-Min2, LIU Su-Hu1 1. Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China 2. Department of Respiratory Medicine, The First Affiliated Hospital, Xi' an Jiaotong University, Xi'an, Shaanxi, 710061, P. R. China  
BACKGROUND OBJECTIVE: Metastasis-associated protein S100A4 is overexpressed in many malignant tumor cells; it may play a pivotal role in invasion and metastasis of malignant tumors. This study was to determine the expression of S100A4 in human non-small cell lung cancer (NSCLC), and to investigate its correlations to invasion and metastasis of NSCLC. METHODS: The expression of S100A4 in 41 specimens of NSCLC and 6 specimens of normal lung tissues was detected by SP immunohistochemistry. The correlations of S100A4 to clinicopathologic features of NSCLC were analyzed. RESULTS: The positive rate of S100A4 was significantly higher in NSCLC than in normal lung tissues (70.7% vs. 16.7%, P0.05), and was significantly higher in adenocarcinoma than in squamous cell carcinoma (90.0% vs. 52.4%, P0.01). The positive rate of S100A4 was significantly higher in stage Ⅲ-Ⅳ than in stage Ⅱ and stage Ⅰ NSCLC (100.0% vs. 66.7% and 30.0%, P0.01), while there was no obvious difference between the latter 2 groups (P0.05). The positive rate of S100A4 was significantly higher in NSCLC with lymphatic metastasis than in NSCLC without lymphatic metastasis (90.0% vs. 52.4%, P0.01), and significantly higher in NSCLC with tumor size of ≥ 3 cm than in NSCLC with tumor size of 3 cm (91.3% vs. 44.4%, P0.001). The expression of S100A4 was closely related to lymphatic metastasis (r=0.480, P=0.001), and tumor size (r=0.288, P=0.017). No significant correlation was found between the expression of S100A4 and pathologic grade of NSCLC (P0.05). CONCLUSION: S100A4 expression is up-regulated in NSCLC, and closely related to lymphatic metastasis, TNM stage and tumor size, which suggest an important role of S100A4 in the invasion and metastasis of NSCLC.
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 6 Hits
1 Lian Li,1 Tong-Hua Mei,1 Xiang-Dong Zhou1 and Xin-Gao2 Zhang1. Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P. R. China 2. Department of Respiratory Medicine, Zigong First People's Hospital, Zigong, Sichuan, 643000, P. R. China;Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer[J];Chinese Journal of Cancer;2009-01
2 ZHENG Xianzhao1,2),LI Shanshan1,2),XUAN Xiaoyan1,2),YAN Aihua1),ZHANG Hongyan2),LI Na1,2),WANG Feng1),GAO Yuan1,2) 1)Department of Pathology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001 2)Department of Pathology,the First Affiliated Hospital,Zhengzhou University;Henan Key Laboratory of Tumor Pathology,Zhengzhou 450052;Expression of S100A4 and MMP-2 in human ESCC cell lines[J];Journal of Zhengzhou University(Medical Sciences);2008-03
3 LU Lin-yuan, AI Kai-xing, HUANG Xin-yu, et al.;Expression of S100A4 in Panceatic Cancer Tissue and Its Significance[J];Journal of Oncology;2008-04
4 WANG Yi,YANG Xu-quan,LU Chang-xing(Department of Chest Surgery,The People's Hospital of Suining,Sichuan 629000,China);The relationship between the expression of cathepsin D and clinical feature of NSCLC[J];Modern Medicine & Health;2008-08
5 Kai-Xing Ai, Lin-Yuan Lu, Xin-Yu Huang, Wei Chen, Department of General Surgery, 6th Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China Hui-Zhen Zhang, Department of Pathology, 6th Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China;Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer[J];世界胃肠病学杂志(英文版);2008-12
6 WU Ai-guo,MA Lei,JI Shu-feng,YANG Hua-feng(Department of General Surgery,Zhujiang Hospital,Nanfang Medical University,Guangzhou 510282,China);Inhibitory effects of silencing S100A4 gene by shRNA on the growth and invasiveness of breast cancer MCF-7 cells[J];Tumor;2009-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Tian Zi-Qiang,Liu Jun-Feng,Zhang Shao-Wei,Li Bao-Qing,Wang Fu-Shun, Zhang Yue-Feng Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang,Hebei,050011, P.R.China;A Study on the Method of DNA Extraction from Unbuffered Formalin-Fixed and Paraffin-Embedded Samples[J];Chinese Journal of Cancer;2004-03
2 LU Zhong-Qiang1, WANG Yi-Min2, CAO Yan-Yan2, ZHANG Qing-Jun3, ZHANG Xiang-Hong4, LI Yue-Hong4, WANG Heng-Shu4, XIE Hui-Ling1, JIAO Bao-Hua1, ZHANG Jian-Hui2 1. Department of Neurosurgery, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China 2. Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China 3. Department of Neurosurgery, People's Hospital, Peking University, Beijing, 100044, P. R. China 4. Department of Pathology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China;Correlations of Polymorphisms in Matrix Metalloproteinase-3 and -7 Promoters to Susceptibility to Brain Astrocytoma[J];Chinese Journal of Cancer;2007-05
3 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
4 GUO Dan,ZHANG Xing-ming,ZHU Dai-hua(Department of General Surgery,Sencond Clinical College,Chongqing University of Medical Sciernces,Chongqing 400010,China);Analysis of canceration factors for adenoma of large intestine[J];Chongqing Medicine;2006-11
5 NAN Qing-zhen, GAO Lei, YANG Xi-shan, XJAO Bing, ZHANG Ya-li, ZHANG Zhen-shu, LIU Xiao-xia (Institute of Digestive Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Relationship between E-cadherin and clinicopathologic finding of colorectal carcinoma[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
6 ZHOU Hai-kuan1, ZHAO Yong-bin2, ZHENG Shao-bin1, CHEN Tong1, MAO Xiang-ming1, QI Huan1, WU Rong-juan1 1Department of Urological Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Department of Urological Surgery, General Hospital of Guangzhou Command, Guangzhou 510010, China;Association of S100A4 mRNA expression with differentiation and metastasis of renal cell carcinoma[J];Journal of First Military Medical University;2005-06
7 ZHOU Qinghua, WANG Yanping, CHE Guowei, ZHU Wen, CHEN Xiaohe, CHEN Xiaofeng, SUN Zhilin. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Establishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human lung large cell carcinoma cell line (WCQH-9801)[J];Chinese Journal of Lung Cancer;2003-06
8 Zhao Junbo, Qiao Yuhuan, Shi Huirong, Zhao Xianlan, Wu Dan, Zhang Xiaoyan (Department of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China);Expression and Significance of S100A4 in Cervical Squamous Carcinoma[J];Henan Journal of Oncology;2005-01
9 Yuan Ping, Sun Menghong, Zhang Jingsheng, Zhu Xiongzeng (Department of Pathology, Medical College of Fudan University, Shanghai 200032);K-ras mutation in sporadic colorectal cancer in China[J];Chinese Journal of Clinical and Experimental Patholog;2000-06
10 ZHAO Qian,HUANG Shi-zhang,OU Sui-fang.(Department of Pathology,the First Affiliated Hospital of Guangdong College of Pharmacy,Guangzhou 510080,Guangdong,P.R.china);Expression of E-cadherin and uPA in human colorectal cancer and its clinical significance[J];China Tropical Medicine;2006-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Bin Li,Xiang-Guo Tian,Cheng-Yong Qin,Department of Digestive Diseases,Provincial Hospital Affiliated to Shan-dong University,Jinan 250021,Shandong Province,China;Advances in calcium-binding protein S100A4 and digestiveneoplasms[J];World Chinese Journal of Digestology;2009-08
2 WANG Bing1, SHANG Peizhong2, WAN Li2, GU Huaping2 (1.The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China; 2.The 251st Hospital of PLA, Zhangjiakou 075000, China);Study on the expression of S100A4 and nm23H1 in papillary thyroid carcinoma and their relationships[J];China Medical Herald;2009-24
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved