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《Chinese Journal of Cancer》 2007-01
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Diagnostic Values of CT Perfusion Imaging in Pulmonary Masses

RUAN Chao-Mei1,2,CHEN Wen-Jing1,2,ZHENG Lie1,2,MO Yun-Xian1,2,ZHOU Zhi-Wei1,3,LU Yan-Chun1,2,XIE Chuan-Miao1,2,LI Li1,2,WU Pei-Hong1,2 1.State Key Laboratory of Oncology in South China, Guangzhou,Guangdong,510060, P.R.China 2.CT Room, Diagnostic Imaging and Intervening Center, Cancer Center, Sun Yat-sen University, Guangzhou,Guangdong,510060, P.R.China 3.Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University,Guangzhou,Guangdong,510060, P.R.China  
BACKGROUND OBJECTIVE:Blood flow patterns with CT perfusion imaging(CTPI) had been innovated to delineate abnormal hemodynamic lesions in the liver,brain,and kidney.This study was to evaluate the blood flow patterns of pulmonary masses by CTPI,and determine the value of CTPI in differential diagnosis among benign,malignant,and inflammatory masses.METHODS:Fifty-two patients with previously diagnosed pulmonary masses(37 with malignant masses,7 with benign masses,and 8 with inflammatory masses) underwent dynamic CTPI.Time-density curves(TDC) of artery,vein,and pulmonary masses as well as mass perfusion images and parameters including perfusion volume(PV),peak height(PH),mean transit time(MTT) and blood volume(BV) were obtained by Phlips CT-perfusion software.RESULTS:The values of PV,PH,and BV were significantly higher in malignant masses and active inflammatory masses than in benign masses [(27.63±15.06) ml·min-1·ml-1 and(30.80±20.33) ml·min-1·ml-1 vs.(11.81±3.74) ml·min-1·ml-1,(28.46±12.07) Hu and(32.15±15.89) Hu vs.(10.41±3.77) Hu,(21.64±10.97) ml/100 g and(28.38±14.55) ml/100 g vs.(10.61±5.33) ml/100 g,P0.01].However,the differences of MTT among malignant,inflammatory,and benign masses were not significant [(28.39±21.66) s,(25.91±14.57) s,and(29.86±13.57) s,P=0.928].No significant differences in the 4 parameters were found between malignant and inflammatory masses.When PV 20 ml·min-1·ml-1 and pH 15 Hu were set as a diagnostic threshold(excluded active inflammatory masses),the sensitivity,specificity,and accuracy were 91.9%,100%,and 84.1%,respectively.CONCLUSION:CT perfusion imaging provides quantitative information about blood flow patterns of pulmonary masses and is an applicable diagnostic method for differentiating pulmonary masses.
【Fund】: 广州市科技攻关项目(No.2001-J-009-02)~~
【CateGory Index】: R816.4
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