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《Chinese Journal of Cancer》 2007-05
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Correlations of Polymorphisms in Matrix Metalloproteinase-3 and -7 Promoters to Susceptibility to Brain Astrocytoma

LU Zhong-Qiang1, WANG Yi-Min2, CAO Yan-Yan2, ZHANG Qing-Jun3, ZHANG Xiang-Hong4, LI Yue-Hong4, WANG Heng-Shu4, XIE Hui-Ling1, JIAO Bao-Hua1, ZHANG Jian-Hui2 1. Department of Neurosurgery, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China 2. Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China 3. Department of Neurosurgery, People's Hospital, Peking University, Beijing, 100044, P. R. China 4. Department of Pathology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China  
BACKGROUND OBJECTIVE: Matrix metalloproteinases (MMPs) are key enzymes involved in tumor development, invasion and metastasis. The single nucleotide polymorphisms (SNPs) in the promoter regions of MMP genes may influence tumor development and progression via modulating mRNA transcription and protein expression. This study was to explore the correlations of the promoter SNPs in MMP-3 and MMP-7 genes to susceptibility to brain astrocytoma. METHODS: The genotype of MMP-3 -1171 5A/6A and MMP-7 -181A/G polymorphisms in 236 patients with brain astrocytoma and 366 healthy controls was detected by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP). RESULTS: The allelotype and overall genotype distribution of MMP-3 SNP among the astrocytoma patients and healthy controls were similar (P0.05). Stratified by sex, age, and histological grade, the susceptibility to brain astrocytoma among the subjects with 5A/5A and 5A/6A genotypes and the subjects with 6A/6A genotype were similar(P0.05). The overall genotype distribution of MMP-7 SNP among the astrocytoma patients and healthy controls were significantly different (P = 0.001). Compared with the A/A genotype, both the G/G and the A/G genotypes significantly increased the susceptibility to astrocytoma [sex- and age-adjusted odds ratio (OR) = 2.77 and 1.69, 95% confidence interval (CI)=1.27-6.02 and 1.01-2.84, respectively]. Stratification analysis showed that the G/G genotype significantly increased the susceptibility to astrocytoma in men (adjusted OR = 3.24, 95% CI = 1.12-9.41) and in the individuals younger than 45 years (adjusted OR = 3.16, 95% CI = 1.09-9.16). When stratified by histological grade, the A/G genotype increased the susceptibility to grade Ⅱ astrocytoma by about 2 folds (adjusted OR = 2.06, 95% CI = 1.05 - 4.05), while the G/G genotype increased the susceptibility to grade Ⅱ-Ⅳ astrocytoma by about 3 folds. CONCLUSION: MMP-7 -181A/G polymorphism may influence the susceptibility to astrocytoma, while MMP-3-1171 5A/6A polymorphism has no correlation to the susceptibility.
【CateGory Index】: R739.4
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【References】
Chinese Journal Full-text Database 1 Hits
1 Lian Li,1 Tong-Hua Mei,1 Xiang-Dong Zhou1 and Xin-Gao2 Zhang1. Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P. R. China 2. Department of Respiratory Medicine, Zigong First People's Hospital, Zigong, Sichuan, 643000, P. R. China;Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer[J];Chinese Journal of Cancer;2009-01
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 CHEN Xiang-Li1, ZHANG Wang-Gang1, CHEN Xiao-Yan2, SUN Zhong-Min2, LIU Su-Hu1 1. Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China 2. Department of Respiratory Medicine, The First Affiliated Hospital, Xi' an Jiaotong University, Xi'an, Shaanxi, 710061, P. R. China;Correlations of S100A4 Protein Expression to Invasion and Metastasis of Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2006-09
2 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
3 LI Yin, ZHOU Qinghua, SUN Zhilin, SUN Zefang, WANG Yanping, QIN Yang, ZHU Wen, CHEN Xiaohe. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Effects of targeting inhibition of ERK1/2 signal transduction pathway on malignant biological behaviors of human high-metastatic large cell lung cancer cell line L9981[J];Chinese Journal of Lung Cancer;2005-06
4 DENG Wei-yi, SUN Wei-wen, FANG Min-hua, WU Jian-wei, HE Wei-wen, CHEN Sheng-qiang (Institute of Neurosciences, Second Affiliated Hospital Guangzhou Medical College, Guangzhou, Guangdong 510260, China);Detection of MMP-9 Mutation Frequencies in Healthy Individuals[J];Academic Journal of Guangzhou Medical College;2005-06
5 CHEN Xiao-Feng~1,TANG Li-Jiang~1,ZHU Min~2,JIANG Jian-Jun~1,SHEN Wei-Feng~3,and DU Yu-Xi~1(1.Department of Cardiology,2.Center Lab,Taizhou Hospital,Wenzhou Medical College,Taizhou 317000;3.Department of Cardiology,Shanghai Ruijin Hospital,Shanghai 200025,China);Matrix Metalloproteinase-9 Polymorphism(C1562T) and the Susceptibility to Myocardial Infaction in Han Population of China[J];Chinese Journal of Arterial Lerosis;2005-06
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