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《Chinese Journal of Cancer》 2008-04
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Inhibitory Effects of Suramin on Growth of Transplanted Lung Adencarcinoma in Mice and Its Mechanisms

HE Jian-Bin1, YI Gao-Zhong1, YANG Kai1, XIANG Zhi1, XIE Mao-Feng1, ZHANG Ping21. Department of Respiratory Diseases, The First People’s Hospital of Huaihua City, Huaihua, Hunan, 418000, P. R. China 2. Department of Respiratory Diseases, The First Affliliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China  
BACKGROUND OBJECTIVE: Recent study found that suramin could inhibit the growth of malignant tumors, but its in vivo effect on lung adenocarcinoma has seldom been reported. This study was to investigate the inhibitory effects of suramin on the growth and metastasis of transplanted lung adenocarcinoma in mice, and explore the mechanisms. METHODS: Lung adenocarcinoma LA795 cells were transplanted into 32 T739 mice. The tumor-bearing mice were randomized into control group, cisplatin (DDP) group, suramin group, and combination (suramin plus DDP) group; each group contained 8 mice. Different treatments were served since Day 4 after transplantation. All mice were killed 24 days after transplantation. The metastatic tumor foci on the lung in mice were counted. The occurrence rate of lung metastasis and the inhibition rate of metastatic foci were calculated. The volume and weight of tumors were measured. The expression of epidermal growth factor receptor (EGFR), P-selectin and proliferating cell nuclear antigen (PCNA) in tumor tissues were detected by immunhistochemistry. RESULTS: DDP and suramin used alone or in combination significantly inhibited the growth of LA795 cells in mice (P0.05), with growth inhibition rates of 34.9%, 23.8% and 57.3%, respectively. The occurrence rate of lung metastasis and the number of metastatic foci on lung surface were significantly lower in suramin group and combination group than in DDP group and control group (P0.05). The protein levels of EGFR and P-selectin were significantly higher in control group than in DDP group, suramin group, and combination group (157.7±6.1 vs. 130.7±5.9, 110.3±5.8, and 89.2±5.4, P0.05; 134.5±5.7 vs. 117.9±5.1, 96.2±5.4, and 78.3±4.5, P0.01). The S phase fraction of tumor cells was significantly higher in control group than in DDP group, suramin group, and combination group [(89.7±3.8)% vs. (68.8±4.0)%, (65.2±4.2)%, and (51.3±4.2)%, P0.01)]. CONCLUSION: Suramin could inhibit the proliferation and metastasis of LA795 cells in T739 mice through regulating the expression of EGFR, P-selectin and PCNA.
【Fund】: 湖南省卫生厅科研基金(NoC2005033)~~
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 OU Chao1, WU Fei-xiang2, LUO Yuan3, CAO Ji1, ZHAO Yin-Nong2,YUAN Wei-Ping2, LI Yuan1, SU Jian-Jia11. Department of ExperimentPathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China2. Department of Hepatobiliary & Breast, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China3. Department of Clinical Pathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China;Expression and Significance of Epidermal Growth Factor Receptor Variant Type Ⅲ in Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2005-02
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Ping, HE Jian-Bin, OU Li-Wen, WANG Xiao-HuaDepartment of Respiratory Medicine, The First Affiliated Hospital, Nanhua University, Hengyang, Hunan, 421001,P. R. China;Effects of Suramin in Combination with Cisplatin on Growth and Metastasis of Lung Adenocarcinoma Xenografts in Mice[J];Chinese Journal of Cancer;2006-04
2 OU Li-wen,LUO Yun-hai.The Department of Respiratory,the affiliated hospital of XiangNan University.Huo Jianbing,Zhang Ping,The teaching and research unit of clinic nurse,The nurse college of NanHua University;The effect of suramin in combination with adriamycin on HIF-1α and VEGF expressions in mice transplanted with lung adenocarcinoma[J];Journal of Chinese Physician;2006-11
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4 YAO Miao-miao, LAI Yong-hong, ZHAI Ying-ying (Department of Pediatrics, First Affiliated Hospital , Guangzhou Medical College, Guangzhou 510120, China);Antitumor Effects of Quercetin in P388 Leukemia Mice[J];Academic Journal of Guangzhou Medical College;2008-01
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7 ZHANG Yi-kang Department of Chinese Medicine,The First Affiliated Hospital of Nanhua University;Effects and Significance of Quercetin plus TNP-470 on ES and VEGF of Transplanted Tissues in Lung Adenocarcinoma Mice[J];Shanghai Journal of Traditional Chinese Medicine;2008-01
8 LU Yue,LIN Song-yi,ZHANG Yan,LIU Jing-bo(Laboratory of Nutrition and Functional Food,College of Quartermaster Technology,Jilin University,Changchun 130062,China);Study on Enzymatic Preparation of Quercetin from Crude Alcohol Extract of Vaccininm uliginosum L.[J];Food Science;2008-12
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1 ZHANG Guangyu *, ZHAO Min, XU Mingtang, YANG Yonghui,WANG Mengshan,YANG Chunzheng *State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China;Correlation of angiogenesis with expression of vascular endothelial growth factor and its receptors in lung carcinoma[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2002-02
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