Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2009-01
Add to Favorite Get Latest Update

A phase Ⅱ trial of epirubicin plus oxaliplatin and fluorouracil as first-line chemotherapy for advanced gastric cancer

Jian-Guo Zhao,1,2 Jian-Ping Xiong,2 Xiao-Jun Xiang,2 Feng Qie,2 Ling Zhang2 and Feng Yu21. Department of Oncology, Shaoxing People's Hospital, Shaoxing, Zhejiang, 312000, P. R. China 2. Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China  
Background Objective : The prognosis of advanced gastric cancer (AGC) is poor. No standard chemotherapy regimens for AGC are available so far. Randomized studies have revealed that epirubicin plus oxaliplatin and 5-fluorouracil (ECF) regimen could improve the response rate and prolong survival in patients with AGC. This study was to evaluate the efficacy and toxicity of EOF regimen as first-line chemotherapy for AGC patients. Methods: Fifty-two patients with pathologically confirmed AGC were entered into the study. On day 1, patients were intravenously injected with 50 mg / m2 epirubicin, infused with 85 mg/m2 oxaliplatin over 2 h, infused with 400 mg/m2 leucovorin (CF) over 2 h followed by a 46-h infusion of 5-fluorouracil at 2600 mg / m2. The cycle was repeated every three weeks. Treatment efficacy was evaluated every two weeks based on the RECIST standard. All patients received at least two cycles of therapy. Results: Patients received a total of 220 cycles of treatment, and all were evaluable for efficacy and toxicity. The overall response rate was 46.15%. Three cases (5.77%) achieved complete responses (CRs), 21 (40.38%) achieved partial responses (PRs), 18 (34.62% ) had stable disease (SD), and 10 had progression disease (PD). The median time to progression (TTP) was 6.5 months and the median survival time (MST) was 9.8 months. Hematologic toxicity included 14 cases (26.92%) of grade 3-4 neutropenia, two of which were accompanied with fever, and four cases of grade 3 thrombocytopenia. The main non-hematologic toxicity included six cases of grade 3 nausea and vomiting (11.54%), and 28 cases of grade 1-3 neurotoxicity (53.84%). No occurrence of treatment related deaths. Conclusion: EOF regimen is effective and well tolerated as first-line chemotherapy for AGC patients.
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved