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《Chinese Journal of Cancer》 2009-01
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Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer

Lian Li,1 Tong-Hua Mei,1 Xiang-Dong Zhou1 and Xin-Gao2 Zhang1. Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P. R. China 2. Department of Respiratory Medicine, Zigong First People's Hospital, Zigong, Sichuan, 643000, P. R. China  
Background and Objective: Matrix metalloproteinase(MMP)-26 has been implicated in genesis, progression, invasion and metastasis of several types of human cancers. This study was to investigate the expression of MMP- 26 protein in invasive non-small cell lung cancer (NSCLC), pre-invasive lung cancer and normal lung tissues, thus to explore the role of MMP-26 in the progression and prognosis of NSCLC. Methods: SP immunohistochemistry was used to measure the expression of MMP-26 protein in 72 specimens of NSCLC, 14 specimens of atypical hyperplasia and 10 specimens of normal lung tissues. Results: The high expression rate of MMP-26 was 0 (0/10) in normal lung tissues, 14.3%(2 /14) in atypical hyperplasia and 59.7%(43/72) in NSCLC. The expression rate of MMP-26 protein was significantly higher in NSCLC than in atypical hyperplasia and normal lung tissues (P0.01); the expression was higher in atypical hyperplasia than in normal lung tissues, but the difference was not significant(P0.05). The high expression rate of MMP- 26 protein was significantly correlated to stage (P0.05 ) and lymph node metastasis(P 0.05 ), but not to age, gender, tumor size and differentiation (P 0.05). Multivariate analysis showed that MMP-26 and stage were independent prognostic factors of NSCLC (P0.05). The disease-free survival and overall survival were shorter in NSCLC patients with high expression of MMP-26 than in those with low expression of MMP-26 (log-rank=19.34 and 23.2, both P0.001). Conclusion: High expression of MMP-26 protein is correlated to carcinogenesis, lymph node metastasis, clinical stage and prognosis of NSCLC. Therefore, MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of NSCLC.
【Fund】: 四川省重大科技项目(No07FG004-002)~~
【CateGory Index】: R734.2
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