Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer》 2009-01
Add to Favorite Get Latest Update

Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer

Lian Li,1 Tong-Hua Mei,1 Xiang-Dong Zhou1 and Xin-Gao2 Zhang1. Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P. R. China 2. Department of Respiratory Medicine, Zigong First People's Hospital, Zigong, Sichuan, 643000, P. R. China  
Background and Objective: Matrix metalloproteinase(MMP)-26 has been implicated in genesis, progression, invasion and metastasis of several types of human cancers. This study was to investigate the expression of MMP- 26 protein in invasive non-small cell lung cancer (NSCLC), pre-invasive lung cancer and normal lung tissues, thus to explore the role of MMP-26 in the progression and prognosis of NSCLC. Methods: SP immunohistochemistry was used to measure the expression of MMP-26 protein in 72 specimens of NSCLC, 14 specimens of atypical hyperplasia and 10 specimens of normal lung tissues. Results: The high expression rate of MMP-26 was 0 (0/10) in normal lung tissues, 14.3%(2 /14) in atypical hyperplasia and 59.7%(43/72) in NSCLC. The expression rate of MMP-26 protein was significantly higher in NSCLC than in atypical hyperplasia and normal lung tissues (P0.01); the expression was higher in atypical hyperplasia than in normal lung tissues, but the difference was not significant(P0.05). The high expression rate of MMP- 26 protein was significantly correlated to stage (P0.05 ) and lymph node metastasis(P 0.05 ), but not to age, gender, tumor size and differentiation (P 0.05). Multivariate analysis showed that MMP-26 and stage were independent prognostic factors of NSCLC (P0.05). The disease-free survival and overall survival were shorter in NSCLC patients with high expression of MMP-26 than in those with low expression of MMP-26 (log-rank=19.34 and 23.2, both P0.001). Conclusion: High expression of MMP-26 protein is correlated to carcinogenesis, lymph node metastasis, clinical stage and prognosis of NSCLC. Therefore, MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of NSCLC.
【Fund】: 四川省重大科技项目(No07FG004-002)~~
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Xiang-Li1, ZHANG Wang-Gang1, CHEN Xiao-Yan2, SUN Zhong-Min2, LIU Su-Hu1 1. Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China 2. Department of Respiratory Medicine, The First Affiliated Hospital, Xi' an Jiaotong University, Xi'an, Shaanxi, 710061, P. R. China;Correlations of S100A4 Protein Expression to Invasion and Metastasis of Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2006-09
2 LU Zhong-Qiang1, WANG Yi-Min2, CAO Yan-Yan2, ZHANG Qing-Jun3, ZHANG Xiang-Hong4, LI Yue-Hong4, WANG Heng-Shu4, XIE Hui-Ling1, JIAO Bao-Hua1, ZHANG Jian-Hui2 1. Department of Neurosurgery, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China 2. Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China 3. Department of Neurosurgery, People's Hospital, Peking University, Beijing, 100044, P. R. China 4. Department of Pathology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China;Correlations of Polymorphisms in Matrix Metalloproteinase-3 and -7 Promoters to Susceptibility to Brain Astrocytoma[J];Chinese Journal of Cancer;2007-05
3 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 HUANG Ri-Sheng1,SUN Cheng-Chao2,WU Hao3,JIN Liang-Da1 1Department of Thoracic Surgery,3Department of Clinic Laboratory,Dingli Clinical College,Wenzhou Medical College,Wenzhou Second People's Hospital,Wenzhou 325000,China,2Department of Thoracic Surgery,First Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000,China;Significance of CD_(44)V6 and E-cadherin protein expression in esophageal carcinoma[J];Journal of the Fourth Military Medical University;2009-24
2 FENG Ping1,ZHOU Yin-jun2,HAN Jia-kai1,ZHUANG Ying-zhi1(1.Department of Oncology,First Affiliated Hospital,University of South China,Hunan,Hengyang 421001,China;2.School of Pharmacy,Central South University,Hunan,Changsha 410013,China);Effects of the Acetoacetate Extract of Vitex Negundo Seed on the Growth of Human Hepatocellular Carcinoma Xenograft in Nude Mice[J];Journal of Hunan Normal University(Medical Sciences);2008-04
3 ZHENG Xianzhao1,2),LI Shanshan1,2),XUAN Xiaoyan1,2),YAN Aihua1),ZHANG Hongyan2),LI Na1,2),WANG Feng1),GAO Yuan1,2) 1)Department of Pathology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001 2)Department of Pathology,the First Affiliated Hospital,Zhengzhou University;Henan Key Laboratory of Tumor Pathology,Zhengzhou 450052;Expression of S100A4 and MMP-2 in human ESCC cell lines[J];Journal of Zhengzhou University(Medical Sciences);2008-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved