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《Chinese Journal of Cancer》 2009-12
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Germ-line epimutations and human cancer

Pu-Yuan Wu,1,2 Yi-Mei Fan1,2 and Ya-Ping Wang1,2 1. Department of Medical Genetics, Medical School, Nanjing University, Nanjing, Jiangsu 210093, P. R. China 2. Jiangsu Key Laboratory of Molecular Medicine, Nanjing, Jiangsu 210093, P. R. China  
Epimutations are errors in the normal process of epigenetic regulation which can result in aberrant transcriptional silencing of a normally active gene or reactivation of a normally silent gene. Epimutations are generally considered to be somatic events and to be confined in affected tissues. However, recent studies of patients with hereditary nonpolyposis colorectal cancer (HNPCC) have showed that allele-specific hypermethylation of CpG islands in the promoter region of the MLH1 gene, one of the causes of the tumor, existed in all the tissues examined. In addition, germ-line epimutations of other tumor suppressor genes (TSGs), such as MSH2 and BRCA1, have also been reported, demonstrating that epimutations might arise in the germ- line (during gametogenesis or early embryonic development). The role of germ-line epimutations might be as important as germ-line mutations in human disease. We reviewed the update on germ-line epimutations of TSGs including the possible mechanisms underlying germ-line epimutations, the possibility of transgenerational inheritance, and their impact on our understanding of human disease.
【Fund】: 江苏省自然科学基金项目(编号:BK2008269);; 江苏省国际科技合作计划项目(编号:BZ2008055)~~
【CateGory Index】: R730.2
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 YUAN Yun fei 1, LI Jin qing1, YANG Zu li2, WANG Jian ping2*1. Tumor Hospital, Sun Yat sen University, Guangzhou 510060, P.R.China.2. The First Affiliated Hospital, Sun Yat sen University 510089, P.R.China;The Roles of DNA Methylation in Human Neoplasms[J];Chinese Journal of Cancer;2002-11
2 LI Jian-Hua1, SHI Xian-Zhe2, LIU Min1, WANG Yan1, YU Zhi-Hong1, XU Guo-Wang2, LU Shen11. Laboratory of Molecular Biology, Experimental Center,The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, 116027, P.R.China2. National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences,Dalian, Liaoning, 116011, P.R.China;Methylation of hMLH1 Gene Promoter in Gastric Carcinoma with Microsatellite Instability[J];Chinese Journal of Cancer;2005-03
3 TENG Li-Juan, LI KeDepartment of Molecular Epidemiology, Medical College, Shantou University, Shantou, Guangdong, 515041, P. R. China;Research Progress on the Relationship between Nutrition and Cancer Epigenetics——Histone Modification Mechanisms[J];Chinese Journal of Cancer;2007-09
4 ZHANG Qian1,JIN Jie1,TAO Qian2 1. Department of Urology,Institute of Urology,The First Hospital,Peking University,Beijing,100034,P. R. China 2. Cancer Epigenetics Laboratory,State Key Laboratory in Oncology in South China,Sir YK Pao Center for Cancer,Department of Clinical Oncology,Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences,Chinese University of Hong Kong,Hong Kong;Aberrant Methylation of Tumor Suppressor Genes in Renal Cell Carcinoma[J];Chinese Journal of Cancer;2007-11
5 WANG Xi,ZHU Wei-Guo Department of Biochemistry and Molecular Biology,Peking University,Health Science Center,Beijing,100191 P.R.China;Advances in Histone Methyltransferases and Histone Demethylases[J];Chinese Journal of Cancer;2008-10
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LIU Wen-Ji1,2, WANG Li1,3, WANG Jian-Ping4, LI Jin-Qing1,2,ZHANG Chang-Qin1,5, ZHENG Lie1,6, YUAN Yun-Fei1,21. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China3. Laboratory of Clinical Oncology, Cancer Center,Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China4. Department of Gastrointestinal & Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China5. Department of Tumor Resource, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China6. Department of Medical Imaging & Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Correlations of CpG Island Methylator Phenotype and OPCML Gene Methylation to Carcinogenesis of Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2006-06
2 QIAN Bing1,2,KE Pei-Qi1,WANG Li3,4,LIU Wen-Ji3,4,LI Mei-Xiang3,4 1. Department of Obstetrics and Gynecology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,510080,P. R. China 2. Department of Obstetrics and Gynecology,The Affiliated Drum Tower Hospital,Medical School,Nanjing University,Nanjing,Jiangsu,210008,P. R. China 3. State Key Laboratory of Oncology in South China,Guangzhou,Guangdong,510060,P. R. China 4. Department of Hepatobiliary Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P. R. China;Expression and Methylation of Adenomatous Polyposis Coli Gene in Endometrioid Adenocarcinoma[J];Chinese Journal of Cancer;2008-06
3 MENG Chun-Feng1, DAI Dong-Qiu1, GUO Ke-Jun21. Department of Surgical Oncology, Department of General Surgery, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110001, P. R. China 2. Department of Gynecology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110001, P. R. China;Effects of 5-Aza-2'-deoxycytidine and Trichostatin A on DNA Methylation and Expression of hMLH1 in Ovarian Cancer Cell Line COC1/DDP[J];Chinese Journal of Cancer;2008-12
4 Lin Yang,1,2 Jian-Min Luo,1,2 Shu-Peng Wen,1,2 Xiao-Jun Liu,1,2 Xing-Yan Du1,2 and Yan Li1,21.Department of Hematology,The Second Affiliated Hospital,Hebei Medical University,Shijiazhuang,Hebei,050000,P.R.China 2.Key Laboratory of Hematology of Hebei Province,Shijiazhuang,Hebei,050000,P.R.China;Effect of As_2O_3 on demethylation of SHP-1 gene in human lymphoma cell line T2[J];Chinese Journal of Cancer;2009-03
5 JIANG Lei,QIN Yang~△,SUN Zhi-lin,SUN Ze-fang,WANG Jin-hong,YANG Lu-chuan.Department of Biochemistry and Molecular Biology,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China;Research on Promoter Region Methylation Status of Tumor Repressor Gene P16 in Human Hepatocellular Carcinoma by Using Methylation Sensitive Restriction Enzyme and Semi-nested PCR Assay[J];Journal of Sichuan University(Medical Science Edition);2007-01
6 TAO Mei-man, SUN Hao, MA Ke-jun, ZHANG Shun-xing, YOU Hai-yan1 (Department of Urology,1the Central Laboratory, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China);Effect of 5-Aza-2’-deoxycytidine on growth inhibition of renal carcinoma cell line OS-RC-2 and reversion of γ-catenin gene hypermethylation[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2009-06
7 YANG Jing,DU Wen,HE Yanli,et al.Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Research on PTEN Expression and Its Promoter Methylation in B-ALL Patients[J];Journal of Internal Intensive Medicine;2007-04
8 WANG Qi,HU Feng-cheng,LI Chun-ming;Research Advances in DNA Methylation[J];Sci-Tech Information Development & Economy;2009-29
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Lei, XING De yin, TAN Wen, HE Zu gen,LIN Dong xin* Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, P.R.China;Promoter Hypermethylation of DNA Repair Gene MGMT in Esophageal Squamous Cell Carcinoma[J];Chinese Journal of Cancer;2001-12
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