TMSG-1 and its roles in tumor biology

Xiao-Yan Xu,Fei Pei,Jiang-Feng You Peking University Health Science Center Department of Pathology,School of Basic Medical Sciences,Beijing 100191,P.R.China  

TMSG-1 is a newly discovered tumor metastasis suppressor gene,which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells.The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide,but the underlying mechanism remains unknown.Studies on TMSG-1 are limited worldwide,and only a research group in Shanghai and our group have recently studied on it.As a new research field,the function of TMSG-1 remains to be explored.This review discusses the discovery of TMSG-1,structure of its encoded protein,its roles and possible mechanism in inhibiting tumor invasion and metastasis.

【Key Words】： TMSG-1 V-ATPase ceramide
【Fund】： National Natural Science Foundation of China (No. 30971142)
【CateGory Index】： R730.2

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