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《CHINESE JOURNAL OF CANCER》 1995-02
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ESTABLISHMENT AND CHARACTERIZATION OF A XENOGRAFTED NASOPHARYNGEAL CARCIONOMA AND EORRESPONDING EPITHELIAD CELL

LINE Wu Y.T. Wang H. M. Yang X.P.Li M.Z.Chen J. Fang Y.Jian S.W. Zhang L.Cancer Institute, Sun Y at-sen U niversity of Medical Sciences Guangzhou/ 510060)Wu Q.L.Zhang W.T.(Canaer Hospital,Sun Yat-sen University of Medical Sciences Guangzhou,510060  
A xenografted nasopharyngeal carcinoma and corresponding cancercell line, designated as SUNT-1 and SUNE-1 respectively,were success fully establishedfrom a fresh biopsy of NPC. A Series of studies,including biological characteristics ofthe xenografts, histopathology,electromicrose opy,cytogenetic and the relationship of Ep-stein-Barr Virus(EBV)to the cancer cells,have been done。It has been confirmed thatboth of the xenograft and cell culture consist of typicai poorly-differentiated squamou scancer cells,and exhibit a human aneuploid karyotype by the cytogenetic study. By usingPGR technique, EBV-DNA was found in the cells from SUNT-1 passage 1 to l8 and inSUNE-1 cells up to 61st passage of all have been studied. The follow-up study is ongoing。Southern hybridization and“In situ lying gel” studies also exhibit the related speci-fic bands of EBV-DNA。The mutation of exon 8 of P53 gene was found using the nonradio active aPCR-SSCP。It is worth to note that we were able to identifv the linear fromof EBV-DNA,as well as the 96~l00 nm of diameter EBV-like particles,in the cells of SUNT-1and SUNE 1-up to P 18 and P53 separately. Further studies are being carried inour laboratory for using these cancer cells as a valuable too l in the studies of N PC,especially the potential role of EBV in the etiology and development of NPC。
【Fund】: 美国中华医学基金
【CateGory Index】: R73-35
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