THEKAPEUTIC RESULTS OF ADVANCED GASTROINESTINAL CANCERS TREATED BY HIGH DOSE OF LEUCOVORIN(HDCF)AND 5FU
LIU Hua; YANG Zuoheng; WANG Wei Dept.of oncological medicine, the people's Hospital of Hainan province, Haikou 570102
High dose of Leucovorin (HDCF)and 5FU therapy were used in 17 histologically proven ad- vanced gastrointestinal cancer patients,among them 8 cases were gastric cancer,9 wpre coloniC cancer.HD- CF 200 mg i.v.drip in 2h;5FU 1 gm was given i.v. drip for more than 14h,starting while HDCF was given half way.The treatments were repeated for 5 day,and the course was repeated after 21 days. progressive cases the clinical symptoms were amiolerated and the life quality waseleveated after this chemotherapy schedule. Median Follow-up of all patients was 11 months,8 cases of gastric cancer survived for 4-22 months(median 8 months);9 cases of colon cancer survived for 4-21 months(madian 16 months),in which 5 cases died,4 cases has survived for 14、16、16、17 months,respec- tively.Among side effects phlebitis was most common seen,in 70.6 % of the cases; the other symptomswere dibestive tract reactions,an elevated SGPT level,all were grade I-II.Advanced digestive tract can- cer patients could tolerate this treatment well.it is worthwhile of further study.