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Induction of apoptosis by annonaceons acetogenins in human breast cancer cell line MCF-7/ADR

Cheng Guanjun Pan Qichao Fu Liwu, et al.Cancer Institute, Sun Yat-sen University of Medical Sciences, Guangzhan, 510060  
Objective: To investigate the induction of apoptosis of human breast cancer cell line MCF-7/ADR by Annonaceons acetogenins (AA) in order to demonstrate the mechanism of its anticancer action. Methods: MTT method, TUNEL, flow cytometry (FCM), light microscopy and transmission electronmicroscope were used. Results: MCF-7/ADR treated with AA underwent cell proliferation inhibition, IC50 is 10.5 mg/L; cell shrinkage, condensation cell chromatin clinged to periphery of the nuclear and fragmentated can be detected by light microscopy and transmission electronmicroscope, apopttotic peaks were also detected on FCM, the TUNEL-positive cells were 57.3% after being treated with AA at 10 mg/L for 48 hours. Conclusion: AA can induce apoptosis of MCF-7/ADR cell line.
【Fund】: 国家教委博士点基金
【CateGory Index】: R737.9,R730.53
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