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Study on Hypoglycemic Effect of Momordica saponins and Its Mechanism

WANG Xian-yuan, JIN Hong, XU Zhi-qin, GAO Lan-xing (Institute of hygiene and environmental medicine, Academy of military and medical sciences, 300050 Tianjin)  
Male Wistar rats, weight from 170 to 190 grams, were divided into normal control group(NC), experimental control group(EC), experimental group 1 and 2 (E1 and E2). Two control groups were allowed to drank tap water, E1 and E2 were supplied with tap water containing 100 mgL 1 and 200 mgL 1 Momordica saponins respectively. After 5 weeks, plasma from the last three groups fasted for 24hrs were collected. Ther the rats were fed again and drawn plasma at postprandial 24 hr. Samples of muscle and liver were got after one week. Results: Momordica saponins could not affect the level of plasma insulin, but increase levels of glucose and cortisone significantly in fasting rats. And levels of plasma glucose and cholestrol were decreased obviously in two experimental groups postprandial. At the same time, Momordica saponins could raise the level of glycogen in muscle and liver in some extent.
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