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《Amino Acids & Biotic Resources》 2011-03
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Effect of Antimicrobial Peptide MDL-2 from Musca domestica Larvae on Permeability and Metabolism of Bacteria

GONG Xia1,WANG Lan-fang2,LE Guo-wei3(1.Department of Food Science,Shanghai Business School,Shanghai 200235; 2.School of Medicine,Tongji University,Shanghai 200092;3.School of Food Science,Jiangnan University,Wuxi 214036,China)  
Effect of antimicrobial peptide MDL-2 from Musca domestica larvae on dissolution and permeability and metabolism of bacteria were investigated.The cell wall of bacteria was ruptured by interaction of antimicrobial peptide MDL-2 with bacteria.Gram-negative bacteria E.coli had concentration-dependency when antibacterial peptide MDL-2 assembled to certain concentration on cell outer membrane.The cell wall of Gram-positive bacteria S.aureus were fallen apart in lower concentration of MDL-2.The S-type graph showed synergism while MDL-2 interplayed with cytoplasmic membrane of S.aureus.Metabolism function of bacteria was interfered with antibacterial peptide MDL-2,so bacteria were accelerated death.
【Fund】: 上海市教委科研创新项目(09YZ470);; 中央级科研院所基础性专项资金工作项目重点项目(2001DEA-20022)
【CateGory Index】: Q93
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