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《Journal of Anhui Technical Teachers College》 2005-01
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Experimental Study on Effects of Anti-tumour of Exopolysaccharides of Aphanothece halophytica (EPAH) in Mice

CHENG~1 Qi-ping, ZHOU~1 Shou-biao,ZHENG~2 Wei-fa (1.College of Life Science, Anhui Normal University, Wuhu 241000,China; 2. Key Laboratory on Biotechnology for Medicinal Plants of Jiangsu Province, Xuzhou Normal University , Xuzhou 221116,China)  
Objective:To observe the anti-tumour effects of EPAH in mice.Methods: We used S 180-bearing mice as animal model,S 180 tumour was inoculated in oxter of forelimb or abdominal cavity of mice separately. The inhibitory effects of EPAH on the transplanted tumour cells of S 180 in mice were investigated by tumour weight,immune ability , the number of WBC,living time and the rate of the Erythrocytes to adhere to tumour cells. We also observed the anti-tumour action to SMMC 7721 cells in vitro by MTT method. Result:EPAH can obviously inhibit the proliferation of the Sarcomal 180 (S 180) cells, SMMC 7721 cells in vivo or vitro ,enhance the rate of the Erythrocytes to adhere to tumour cells ,it also enhance the immunological function and recovers the reduced number of WBC, prolong the living time.
【Fund】: 江苏省高新技术产业化项目(O2KJ360008)
【CateGory Index】: R285
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