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《Journal of Safety and Environment》 2004-04
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Investigation of toxicity effect for chlorophenols and alkyl phenols on Zebrafish Embryos

LIU Hong-ling, ZHOU Yu, XU Yan, YU Hong-xia (State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210093, China)  
The paper aims at presenting the authors' investigation of the negative influence of such toxicity as chlorophenols and alkyl phenols on the development of Zebrafish embryos. The results indicate that chlorophenols and alkyl phenols are remarkably harmful to the healthy growth of Zebrafish embryos, which is likely to lead to the embryo's abnormality and even lethality. The most sensitive toxicological endpoints to different compounds were determined at 0 hour past fertilization (hpf): pentachlorophenol - 48 h EC_(50) values for rate of the heartbeating, the development of melanocytes and pericardial oedema seem to be equal, 0.2 mg/L; 4-nonylphenol - 72 h EC_(50) value for hatched rate was 0.5 mg/L; 4-octophenol - 72 h EC_(50) value for malformation was 0.5 mg/L; 4-chlorphenol - 48 h EC_(50) value for development of melanocytes was 1.5 mg/L. In addition, the results also demonstrate that the toxicity influence on the embryos may change with the initial and continuous exposure. The toxicities of these chemicals exposed to the embryos for 24 hours after the fertilization may come into effect by following the order: 4-chlorphenol 4-octophenol ≈ 4-nonylphenol pentachlorophenol. Based on the teratogensis exposed to alkyl phenols, the effect can be expected to be correspondent with that of alkyl phenols, which are the typical environmental endocrine disrupting chemicals.
【Fund】: 国家基础研究重大项目前期研究专项 ( [2 0 0 1] 5 0 )
【CateGory Index】: X503.2
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