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《Journal of Safety and Environment》 2009-02
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Analysis of the joint toxicity effects on limiting the 14 substances in accordance with the healthy drinking water quality standards

ZHANG Ya-dan,XU Ya-tong,ZHU Wen-jie(Key Laboratory of Urbanization and Ecological Restoration,EastChina Normal University,Shanghai 200062,China)  
This paper is aimed to investigate the joint effects of low doses of pollutants in drinking water on the safety of human health through the analysis of the toxicity effects of the mixtures of the 14 substances in Healthy drinking water quality standards (GB 5749— 2006)with different pH in it.The paper has also analyzed the kinetic curve of the mixture with different degrees of dilution of negative ef- fects.In order to define the effects of the joint toxicity on the lumi- nescent bacteria,we have made sure respectively the single toxicity of cupric chloride,zinc chloride and potassium dichromate of the four- teen substances,as well as the joint toxicity of binary mixtures in e- quiconcentration and equitoxicity ratios to luminescent bacteria.In addition,additive index method has also been used to evaluate the joint toxicity effect.The conclusion has thus been made that the mix- tures of the 14 substances tend to produce negative effect on the lumi- nescent bacteria.If 5 minutes were given to let the suppression ration of 100% to react to the mixture,the suppression ration would reach 92.53%,while the suppression ration was zero,if it reacted for 20 minutes and with its concentration of 68.38% for 15 minutes.How- ever,the suppression ration would get to 92.53 %,if the suppression ration was zero and was let to react for 20 minutes.Thus,our experi- ments have shown that EC_(50)proves the strongest condition,just next to the neutrality condition and alkaline condition.In addition,a con- sistent conclusion has also been drawn from both equiconcentration mixtures and equitoxicity ones that the joint effect of the binary mix- ture of cupric chloride and potassium dichromate tends to be antago- nistic with the joint effects of the cupric chloride and zinc chloride, with zinc chloride and antagonistic being synergistic.Therefore,the results of our experiments indicate that although the concentrations of the 14 substances prove below the Healthy Drinking Water Quality Standards,the coexistence of the joint toxicity of such elements proves to be remarkable and detrimental to the organisms in the envi- ronment around us as well as to our health.
【Fund】: 上海市“登山行动计划”世博会科技专项课题(06DZ05825);; 上海建设与交通委员会项目(建重2008-005)
【CateGory Index】: R123.1
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