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《Journal of Safety and Environment》 2014-04
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Effects of DTPA and Sm on the liver of mice

ZHANG Jian-guo;LUO Shun-zhong;CHU Shi-jin;CHEN Xiao-ming;PENG Ru-fang;School of Life Science and Engineering,Southwest University of Science and Technology;Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics;School of Materials Science and Technology,Southwest University of Science and Technology;  
To investigate the effects of DTPA and samarium on the liver tissues of mice,we have divided Kunming mice randomly into four groups( 30 mice in each group),that is,the physiological saline control group, the DTPA( 0. 7 mmol /kg) group, the SmCl3( 400 mg/kg) group and 400 mg/kg SmCl3+ DTPA. SmCl3 and DTPA were given separately through peritoneal injection and intravenous injection with a single dose. The said mice were killed then at the 1st,7th and 14 th day separately. And,then,the organ coefficient of liver,the activities of superoxide dismutase( SOD),the contents of malondialdehyde( MDA) and Sm in the liver were also detected. The results of the experimental group treated by DTPA when compared with the physiological saline control group indicate that the liver cells swelled up noticeably,with the SOD activity significantly increased( p 0. 01) but with no change in MDA content and organ coefficient of the liver. The organ coefficients of liver of SmCl3+ DTPA group turned to be significantly lowered( p 0. 01) and showed an increasing trend,the SOD activity was becoming significantly lower( p 0. 05) on the 1st day and then becoming noticeably higher( p 0. 05) on7 th day later. In addition,the MDA content was merely appeared noticeable difference and lower significantly( p 0. 01) on the7 th day when compared with the physiological saline control group and DTPA group. At the same time,the mass ratio of samarium has been found reduced to 8. 590 0 μg /g in SmCl3+ DTPA group,and no noticeable difference was found with the physiological saline control group on the 14 th day,which is significantly lower than that in SmCl3group( p 0. 01). All this indicates that DTPA has a certain effect on the liver histopathology of the mice such as the cellular swelling of the liver tissue,etc. However,the damage of the liver histopathology of the said mice turned to be abated when DTPA acted as eccritic for samarium.
【Fund】: 国家自然科学基金项目(11075134);; 国防科工局基础研究项目(B1520110007)
【CateGory Index】: X174;X503.22
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【Co-citations】
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1 SHI Cui-e,ZHAO Shi-ming,LI Er-qian,WANG Chen,WANG Hao,WANG Cheng-run(School of Life Science,Huainan Normal University,Huainan 232001,China);Effect of La~(3+) on Activities of Antioxidant Enzymes in Aspergillus Niger[J];Chinese Rare Earths;2010-04
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