Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Safety and Environment》 2014-04
Add to Favorite Get Latest Update

Effects of DTPA and Sm on the liver of mice

ZHANG Jian-guo;LUO Shun-zhong;CHU Shi-jin;CHEN Xiao-ming;PENG Ru-fang;School of Life Science and Engineering,Southwest University of Science and Technology;Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics;School of Materials Science and Technology,Southwest University of Science and Technology;  
To investigate the effects of DTPA and samarium on the liver tissues of mice,we have divided Kunming mice randomly into four groups( 30 mice in each group),that is,the physiological saline control group, the DTPA( 0. 7 mmol /kg) group, the SmCl3( 400 mg/kg) group and 400 mg/kg SmCl3+ DTPA. SmCl3 and DTPA were given separately through peritoneal injection and intravenous injection with a single dose. The said mice were killed then at the 1st,7th and 14 th day separately. And,then,the organ coefficient of liver,the activities of superoxide dismutase( SOD),the contents of malondialdehyde( MDA) and Sm in the liver were also detected. The results of the experimental group treated by DTPA when compared with the physiological saline control group indicate that the liver cells swelled up noticeably,with the SOD activity significantly increased( p 0. 01) but with no change in MDA content and organ coefficient of the liver. The organ coefficients of liver of SmCl3+ DTPA group turned to be significantly lowered( p 0. 01) and showed an increasing trend,the SOD activity was becoming significantly lower( p 0. 05) on the 1st day and then becoming noticeably higher( p 0. 05) on7 th day later. In addition,the MDA content was merely appeared noticeable difference and lower significantly( p 0. 01) on the7 th day when compared with the physiological saline control group and DTPA group. At the same time,the mass ratio of samarium has been found reduced to 8. 590 0 μg /g in SmCl3+ DTPA group,and no noticeable difference was found with the physiological saline control group on the 14 th day,which is significantly lower than that in SmCl3group( p 0. 01). All this indicates that DTPA has a certain effect on the liver histopathology of the mice such as the cellular swelling of the liver tissue,etc. However,the damage of the liver histopathology of the said mice turned to be abated when DTPA acted as eccritic for samarium.
【Fund】: 国家自然科学基金项目(11075134);; 国防科工局基础研究项目(B1520110007)
【CateGory Index】: X174;X503.22
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 SHI Cui-e,ZHAO Shi-ming,LI Er-qian,WANG Chen,WANG Hao,WANG Cheng-run(School of Life Science,Huainan Normal University,Huainan 232001,China);Effect of La~(3+) on Activities of Antioxidant Enzymes in Aspergillus Niger[J];Chinese Rare Earths;2010-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 TIAN Guo Zhong 1, LI Huai Fang 2, QIU Wei Fan 2(1.Research Institute of Forest Environment and Protection,Chinese Academy of Forestry, Beijing 100091, China; 2.College of Plant Science and Technology, China Agricultural University, Beijing 100;Advances on Research of Plant Peroxidases[J];Journal of Wuhan Botanical Research;2001-04
2 Yan Chongling Hong Yetang Wang Shijie Fu Shunzhen Yang Xianke Zhu Keyong Wu Shanyi(The State Key Laberatory of Environmental Geochemistry t Chinese Academy of Sciences, Guizhou, 550002; Guizhou Institute of Environmental Protection, Guizhou 550002);Effect of Rare Earth Elements on the Response of the Activated Oxygen Scarenging System in Leaves of Wheat[J];Acta Agronomica Sinica;1999-04
3 Zhang Hui, Feng Jia, Zhu Weifang( Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China );Characteristic of Rare Earth Distribution in Biologic Chains of Rare Earth Rich Background Regions[J];JOURNAL OF THE CHINESE RARE EARTH SOCIETY;1999-04
4 Zhou Feng~1*, Chen Fu~1, Cao Jianhua~2, Pu Lijie, Peng Buzhuo~1 (1. Laboratory of Soil and Water Stimulating, Department of Urban and Resources Sciences, Nanjing University, Nanjing 210093, China; 2. Institute of Agricultural Resources and Eco-Environment, Nanjing Agricultural University, Nanjing 210009, China);Effects of Rare Earth Elements on Microbial Characteristics and Temporal Availability in Rice Soil[J];Journal of The Chinese Rare Earth Society;2003-05
5 Li Rongchang~1, Yang Xiaoda~1, Wang Kui~1, Ni Jiazuan~2 (1. Department of Chemical Biology, Peking University School of Pharmaceutical Science, Beijing 100083, China; 2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China);Research Progress of Bioinorganic Chemistry of Rare Earths[J];Journal of The Chinese Rare Earth Society;2004-01
6 SHAO Jian hua 1,HAN Yong sheng 2,GAO Zhi xiang 2 (1 Jiangsu Rugao Research Institute of Light Industry,Rugao 226500,China; 2 Nantong Suzhong New Fertilizer Tech Institute,Nantong 226561,China);Research Progress in the Production and Application of Amino Acid Rare Earth Trace Element Fertilizer[J];Chinese Rare Earths;2001-05
7 Wan Qiang,Tian Jirong,Peng Haihua,Zhang Xiouju (Hunan Academy of Agricultural Sciences,Changsha,410125) Lee Dong Wook,Woo Chan Ki,Ryu Jong Woan,Park Chun Soo (Chong Eup Shi Rural Guidance Office Rural Extension,Chollabug Do,Republic of Korea);Effect of Rare Earth Increasing Yield and Improving Quality and Reducing Agricultural Chemical Remains in Crop Products[J];CHINESE RARE EARTHS;1998-05
8 Shen Guangping;Correlation Between Mic-ronucleus and Chromosome Aberration[J];Hereditas(Beijing);1985-01
9 QU Ai~1,WANG Cheng-Run~2,BO Jun~1 (1.Department of Biology, Xuzhou Normal University, Xuzhou 221116, China; 2.Department of Chemistry and Biology, Huainan Normal College, Huainan Anhui Province 232001, China);Research on the Cytotoxic and Genotoxic Effects of Rare-earth Element Holmium to Vicia faba[J];Hereditas(Beijing);2004-02
10 Xie Zubin, Zhu Jianguo *, Chu Haiyan , Zhang Yali , Zeng Qing, Cao Zhihong (Laboratory of Material Cycling in Pedosphere, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China);Influence of Lanthanum on Phosphorus Uptake and Its Chemical Fractions in Rice Crop (Oryza Sativa)[J];稀土学报(英文版);2003-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved