Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Oncology Progress》 2003-01
Add to Favorite Get Latest Update

Studies on the synergetic effect of Icariin and/or HMBA derivative on K562 cells

Di Kaijun Zhang Jingbo (Department of Cell Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China)  
To study the independent and synergetic effect of Icariin or/and HMBA derivative on K562 cells and its possible mechanism. Methods Light microscope, electron microscope were used to detect the morphological changes of K562 cells; to detect the apoptosis of the cells immuno - fluorescence staining was carried out. Results Icariin and HMBA dervative can apparently inhibit the growth of K562 cells, moreover they have synergetic effect on growth of the cells when they are added together. K562 cells treated with Icariin for 48h showed obvious morphological changes and some characteristics of apoptosis and it was more apparently after 72h. HMBA derivative also can result in morphological changes of K562 cells such as the irregulatory morphology and mitochondrion swelling although there was no obvious trend of differentiation and apoptosis. Conclusions The using of Icariin and HMBA derivative independently or synergically can inhibit the growth of K562 cells. The effect is stronger as they are used simultaneosly. The effect is related with the concentration used. Icariin can partly induce apoptosis of the cells.
【Key Words】: Icariin HMBA derivative K562 cell line apoptosis
【Fund】: 北京市自然科学基金资助项目(7002024)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Di Kai-jun~①, Zhang Jing-bo~② ①Graduate Student and ②Professor, Department of Cell Biology, Institute of Basic Medical Sciences, CAMS, Beijing 100005;An Outline of Icariin Pharmacological Study[J];Nature Magazine;2003-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Luo Yuankai et al.(Guangzhou Institute of Chinese Traditional Medicine, Guangdong);Clinical Research on Menopausal Syndrome Treated with Chief Method of Tonifying the Kidney[J];;1990-02
2 LIU Zhi-liang*, XU Ru-xiang, YAO Zhi-bin, WANG Rao, MA Hong-wei. *Postdoctoral Programme Station, Foshan First People's Hospital, Sun Yat-Sen University, Foshan 528000, China;Change of MAPKs activation in rat hippocampus following kainic acid-induced epileptic seizures[J];Chinese Journal of Neuromedicine;2006-02
3 Li Shutong; Li Tiejun; Zheng Qinyue; Wang Hongbin (Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai,200433);Effects of icariine on lymphocyte proliferation and production of colony stimulating factor-like activity from mice splenocytes in vitro[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-04
4 Li Shutong;Li Tiejun;Zheng Qinyue;Wang Hongbin(Department of Pharmacology,College of Pharmacy,Second Military Medical University,Shanghai,200433);Effects of icarrin on function of murine peritoneal macrophages[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-06
5 LI Li~ 1 , ZHOU Qi-xin~ 1 , SHI Jing-shan~ 2 (~ 1 Research Center of Biochemistry and Molecular Pharmacology, Chongqing University of Medical Sciences, Chongqing 400016, ~ 2 Department of Pharmacology, Zunyi Medical College, Zunyi 563003, China);Effect of icariin on expression of cytochrome C oxidase subunit Ⅱ mRNA in mice of cerebral ischemia/reperfusion[J];Acta Academiae Medicinae Militaris Tertiae;2006-07
6 HUANG Yun-sheng, XIE Wei, CHEN Bao-tianDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;Effect of saikosaponins on epileptic rat electroenciphalogram[J];Journal of First Military Medical University;2004-12
7 Sun Suqin *1 , Du Deguo 1, Liang Xiyun 2, Yang Xianrong 2 1(Department of Chemistry, Tsinghua University, Beijing 100084) 2(Institute of Advanced Chinese Medicing, Hong Kong Baptist University);A Rapid Method for Distinguishing the Different Ganoderma Lucidum Products by Fourier Transform Infrared Spectroscopy[J];Chinese Journal of Analytieal Chemistry;2001-03
8 Zhou Qun, Li Jing, Sun Suqin * (Department of Chemistry, Tsinghua University, Beijing 100084) Liang Xiyun (Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong);Rapid Identification of Traditional Chinese Medicine Formula Particles by Fourier Transform Infrared Spectroscopy[J];Chinese Journal of Analytical Chemistry;2003-03
9 Wang Chaozhan, Geng Xindu * (Institute of Modern Separation Science, Key Laboratory of Modern Separation Science in Shaanxi Province, Northwest University, Xi′an 710069);Isolation and Preparation of Five Flavonol Glycosides from Epimedium Sagittatum by Reversed Phase Liquid Chromatography[J];Chinese Journal of Analytical Chemistry;2005-01
10 LIU Chun-Ming 1,2, LIU Zhi-Qiang 1*, DOU Jian-Peng 1, LI Li 1, LIU Shu-Ying 1* (1. Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; 2. Department of Chemistry, Changchun Teachers College, Changchun 130022, China);Isolation and Structure Identification of the Novel Alkaloid Constituent from Epimedium Koreanum Naki[J];Chemical Research In Chinese Universities;2003-12
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 WU Xiu-qing1,LI Yuan-ke1,LIANG Wei2,et al(1.Sichuan Ziyang Institute for Food and Drugs Control,Ziyang 641300;2.Chengdu University of Traditional Chinese Medicine,Chengdu 610075);Determination of Icariin and Paeonol in Nan Bao Capsules by RP-HPLC[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-02
2 LU Ying-ying, JING Da-dao. Department of Gastroenterology , Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai(200080), China;Current researches and clinical application prospects of stem cells in gut[J];International Journal of Digestive Disease;2006-03
3 DUAN Xu-guang,ZHOU Cong-wen,CHEN Ke,ZENG Lei(Hunan Environment and Biologic Polytechnic,Hengyang,Hunan 421005,China);Determination of icariin in rat plasma in different time by improved RP-HPLC after oral administration of epimedium compound preparation[J];Journal of Hunan Agricultural University(Natural Sciences);2009-03
4 WANG Mei-ling,LI Run-jin,ZHEN Jin(Department of Neurology,Inner Mongolia Hospital,Hohhot 010017 China);PROGRESS OF PROTECTION NERVI CEREBRALES AND IMPROVING IMMUNE FUNCTION OF HERBA EPIMEDII[J];Acta Academiae Medicinae Neimongol;2008-S1
5 TENG Fei, ZENG Yao-ying, HUANG Xiu-yan, YANG Zhi, YAO Man-lin, SONG Bing, LI LinInstitute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China;Effect of icariin on intermediate and advanced activation of murine T lymphocytes in vitro[J];Chinese Journal of Cellular and Molecular Immunology;2008-11
6 DUAN Xuguang,ZHOU Chongwen,CHEN Ke,ZENG Lei (Hunan Environment and Biologic Polytechnic,Hengyang 421005,China);Pharmacokinetics analysis of icariin in rats coming from Chinese medicine compound recipe and single medicinal materials[J];China Medical Herald;2009-19
7 Dan-yah ZHU Yi-jia LOU~2 Department of Pharmacology and Toxicology,College of Pharmaceutical Scienees,Zhejiang University,Hangzhou 310031,China;Inducible effects of icariin,icaritin,and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro[J];中国药理学报(英文版);2005-04
8 WANG Xin, WANG Ting-ting, WANG Hai-jun, WENG Dai-qun, YANG Yong, LI Qing, LUO Wei-zao(Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China);Optimization of the Extraction Technology of Icariin from Herba Epimedii[J];China Pharmacy;2009-09
9 ZHAO Xiaoyong WANG Haitao LIU Fucheng SU Jiangning SUN Xilong LIU Yue CHEN Taoping (Hebei Province People's Hospital,Shijiazhuang 050051);Effect of the integral medicine therapy on serum SOD in the patients with cervical syndrome[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2006-04
China Proceedings of conference Full-text Database 1 Hits
1 Wu Xiu-qing1,Li Yuan-ke1,Liang Wei2,Huang Wei1(1.Sichuan Ziyang Institute for Food and Drugs Control,Ziyang 641300;2.Chengdu University of Traditional Chinese Medicine,Chengdu 610075);Determination of icariin and paeonol in Nan Bao Capsules by RP-HPLC[A];[C];2008
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved