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《Oncology Progress》 2005-01
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Establishment of the metastasis and recurrence nude mice models and cell line of human hepatocellular carcinoma and application of models to experimental intervention

Wang Lu # Tang Zhaoyou Liver Cancer Institute & Zhongshan Hospital,Fudan University,Shanghai 200032  
Meatstasis and recurrence is the most prevalent cause of death in patients with hepatocellular carcinoma(HCC),human HCC nude mouse models and HCC cell lines with different metastatic potential were established in our institute.It is found that high-dose and long-term therapy with interferon-α could inhibit tumor growth and recurrence of HCC in nude mice bearing human HCC xenografts with high metastatic potential,the main mechanism was through blocking tumor angiogenesis.
【CateGory Index】: R735.7
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