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《Oncology Progress》 2005-01
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Study on the histopathology in a rat model of bone cancer pain

Tan Huangying # Yu Lili Gao Fuyun Cui Jian Pan Lin Tian Xin Cheng Zhiqiang Jia Liqun Li Peiwen Department of TCM Oncology,China-Japan Friendship Hospital,Beijing 100029,China  
Objective To establish a useful animal model of cancer pain.Methods A rat model of bone cancer pain was developed by intra-tibial inoculations of MRMT-1 rat mammary gland carcinoma cells in Sprague-Dawley rats.Mechanical allodynia was measured by using von Frey test,mechanical hyperalgesia was assessed as the difference of weight bearing between hind paws,measured using a incapacitance tester.The development of the bone tumor and structural damage to the bone was monitored by radiological analysis and histology.Results Rats following intra-tibial injections of MRMT-1 cells displayed the gradual development of mechanical allodynia and hyperalgesia,beginning on day 14 after injection of the tumor cells.The radiograph of the tibia showed clear bone destruction.The sections of the bone showed the bone marrow cavity was full of tumor cells,the cortical bone has been destroyed and replaced by woven bone.Conclusion Results from the studies on behavioral tests,radiology and histology suggest that this model of bone cancer has been copied well,and it will provide us a useful animal model for evaluation of new drugs of cancer pain.
【Key Words】： animal model bone cancer pain MRMT-1 mechanical allodynia
【Fund】： 卫生部重点项目基金;; 浙江康莱特药业有限公司基金共同资助
【CateGory Index】： R738.1
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