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《Oncology Progress》 2005-06
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Gefitinib in elderly and unfit patients affected non-small-cell lung cancer

Shi Xiaochun Zhang XiaotongDepartment of Pulmonary Medicine,PUMC Hospital,CAMS & PUMC,Beijing 100730,China  
Elderly and poor performance status(PS≥2)advanced non-small-cell lung cancer(NSCLC)patients often tolerate chemotherapy poorly.These special patient groups may benefit from gefitinib—the epidermal growth factor receptor tyrosine kinase inhibitor,which is safe and well tolerated.The response rate with gefitinib in patients with PS 2-3 was 13%-17%,disease control was 17.1%-41.6%.In elderly patients,disease control was about 50%.The side effects were generally grade 1/2 skin toxicity and diarrhea.We undertook a review of the published literature on this topic.
【CateGory Index】: R734.2;
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【Co-citations】
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