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《Oncology Progress》 2006-04
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Advances in mechanism and treatment of chemotherapy-induced nausea and vomiting

Zhang Xiaojing Zhang Pin Cancer Hospital,CAMS & PUMC,Beijing 100021,China  
Chemotherapy plays a significant role in the combined therapy of tumour.Chemotherapeutic regimens have improved and are more finely targeted than in the past,but chemotherapy-induced nausea and vomiting(CINV)remains a major obstacle and affects patients' satisfaction with treatment.About 70%~80% patients will face CINV without pretreatment.Efforts to improve antiemetic control further are ongoing.First-generation serotonin receptor antagonists combined with dexamethasone greatly improved the control of CINV during the 1990s.The new advancement involves the use of a new 5-HT_3 receptor antagonist(palonosetron)that differs from available serotonin antagonists in its markedly longer half-life(40 h)and greater binding affinity for the type-three serotonin receptor.Another very promising area focuses on substance P as a therapeutic target.Substance P exerts its effects by binding to the neurokinin NK-1 receptor.Studies with selective NK-1 antagonists have demonstrated promising antiemetic activity.One agent in this new therapeutic class(aprepitant)recently received regulatory approval in the United States for use in combination with a 5-HT_3 antagonist and dexamethasone,defining a new standard of care for highly-emetogenic chemotherapy.This review focuses on the advances in mechanism and treatment of CINV.
【CateGory Index】: R730.53
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